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Angel Investor (Individual)

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Investments

37

Portfolio Exits

1

About Yusuke Sato

Yusuke Sato is the COO of FreakOut.

Yusuke Sato Headquarter Location

Japan

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Latest Yusuke Sato News

Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting

Dec 10, 2018

Nour Shobaki,* Yusuke Sato,* Hideyoshi Harashima Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan *These authors contributed equally to this work Introduction: The development of targeted drug delivery systems is a rapidly growing area in the field of nanomedicine. Methods: We report herein on optimizing the targeting efficiency of a lipid nanoparticle (LNP) by manipulating the acid dissociation constant (pKa) value of its membrane, which reflects its ionization status. Instead of changing the chemical structure of the lipids to achieve this, we used a mixture of two types of pH-sensitive cationic lipids that show different pKa values in a single LNP. We mixed various ratios of YSK05 and YSK12-C4 lipids, which have pKa values of 6.50 and 8.00, respectively, in one formulation (referred to as YSK05/12-LNP). Results: The pKa of the YSK05/12-LNP was dependent not only on the molar ratio of each lipid but also on the individual contribution of each lipid to the final pKa (the YSK12-C4 lipid showed a higher contribution). Furthermore, we succeeded in targeting and delivering short interfering RNA to liver sinusoidal endothelial cells using one of the YSK05/12-LNPs which showed an optimum pKa value of 7.15 and an appropriate ionization status (~36% cationic charge) to permit the particles to be taken up by liver sinusoidal endothelial cells. Conclusion: This strategy has the potential for preparing custom LNPs with endless varieties of structures and final pKa values, and would have poten­tial applications in drug delivery and ionic-based tissue targeting. Keywords: acid dissociation constant, liver sinusoidal endothelial cells, physical targeting, short interfering RNA This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License . By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms .

Yusuke Sato Investments

37 Investments

Yusuke Sato has made 37 investments. Their latest investment was in yup as part of their Seed VC - II on July 7, 2020.

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Yusuke Sato Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

7/29/2020

Seed VC - II

yup

$1.24M

No

East Ventures, Incubate Fund, Logly Investment, Masaru Sunagawa, Shunsuke Ooyu, and Yu Akasaka

3

5/22/2020

Seed VC

Luup

$3.21M

Yes

Akatsuki, ANRI, Atsushi Tamura, Ayataro Nakagawa, Chihiro Asano, East Ventures, GO, Koizumi Fumiaki, Kotaro Chiba, KSK Angel Fund, Makoto Takano, Mitsubishi UFJ Capital, PKSHA Capital, Scrum Ventures, Shunsuke Ooyu, SMBC Venture Capital, Takaya Shinozuka, THE GUILD, Toru Shimada, Yoshinori Fukushima, Yuji Mizoguchi, and Yusuke Mitsumoto

4

1/30/2020

Series A

Mellia Cosmetics

Yes

NOW, Undisclosed Angel Investors, and Yuichiro Kishi

2

10/23/2019

Seed VC

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$99M

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10

9/26/2019

Seed VC

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$99M

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10

Date

7/29/2020

5/22/2020

1/30/2020

10/23/2019

9/26/2019

Round

Seed VC - II

Seed VC

Series A

Seed VC

Seed VC

Company

yup

Luup

Mellia Cosmetics

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Amount

$1.24M

$3.21M

$99M

$99M

New?

No

Yes

Yes

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Co-Investors

East Ventures, Incubate Fund, Logly Investment, Masaru Sunagawa, Shunsuke Ooyu, and Yu Akasaka

Akatsuki, ANRI, Atsushi Tamura, Ayataro Nakagawa, Chihiro Asano, East Ventures, GO, Koizumi Fumiaki, Kotaro Chiba, KSK Angel Fund, Makoto Takano, Mitsubishi UFJ Capital, PKSHA Capital, Scrum Ventures, Shunsuke Ooyu, SMBC Venture Capital, Takaya Shinozuka, THE GUILD, Toru Shimada, Yoshinori Fukushima, Yuji Mizoguchi, and Yusuke Mitsumoto

NOW, Undisclosed Angel Investors, and Yuichiro Kishi

Sources

3

4

2

10

10

Yusuke Sato Portfolio Exits

1 Portfolio Exit

Yusuke Sato has 1 portfolio exit. Their latest portfolio exit was dely on July 11, 2018.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

7/11/2018

Corporate Majority

$991

5

Date

7/11/2018

Exit

Corporate Majority

Companies

Valuation

$991

Acquirer

Sources

5

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