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Investments

37

Portfolio Exits

2

About Yusuke Sato

Yusuke Sato is the COO of FreakOut.

Yusuke Sato Headquarters Location

Japan

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Latest Yusuke Sato News

Making and manipulating capsule-like DNA structures for use in artificial molecular systems

Dec 13, 2021

The DNA microcapsules with patterns made of sequence-designed DNA nanostructures. Credit: Yusuke Sato Biophysicists in Japan have found ways to make and manipulate capsule-like DNA structures that could be used in the development of artificial molecular systems. Such systems could function, for example, inside the human body. The study was a collaboration between Yusuke Sato of Tohoku University and Masahiro Takinoue of the Tokyo Institute of Technology (Tokyo Tech), and the findings were published in the JACS Au. To make the capsules, the researchers first created two different types of DNA nanostructures. Each type was made using three single-stranded DNA molecules with sticky bits at their ends. Due to differences in their DNA sequences, only similar nanostructures stuck together when the two types were mixed. Sato and Takinoue then combined the nanostructures in solution with an oily mixture of charged and non-charged molecules. The mixture was first heated and then cooled, and finally examined under a microscope. The researchers found that water-in-oil droplets had formed, with the DNA nanostructures accumulating at the water-oil interface. The nanostructures came together in different kinds of patch-like patterns, depending on the concentration of each type relative to the other. The scientists also found that the DNA nanostructures agglomerated in a more homogeneous way when an extra X-shaped DNA nanostructure was added to the mix to connect the two types together. This worked just as well inside lipid vesicles as in water-in-oil droplets. Sato and Takinoue were also able to separate the DNA capsules from the droplets and vesicles without losing their capsule -like shapes. Finally, they were able to open the capsules and degrade them using specific enzymes. Schematics of the DNA capsules generation method and their microscopy images. Yusuke Sato The findings demonstrate an approach for constructing and modifying DNA capsules that could have a variety of different functions and purposes. For example, they could be used to carry substances to specific target organs, releasing their cargo when exposed to certain enzymes. They could also be made mobile by using DNA nanostructures that can be manipulated to alter the shapes of the capsules. Or they could be modified with proteins or DNA-based molecular devices to make functional compartmental structures, like cellular membranes. "We believe that functional capsules made from DNA, like the ones we have designed, could provide a new approach for developing capsular structures for artificial cell studies and molecular robotics," say Sato and Takinoue. The team will next work on inserting different types of cargo into the capsules, including DNA information processors, and releasing them in response to specific stimuli. Explore further

Yusuke Sato Investments

37 Investments

Yusuke Sato has made 37 investments. Their latest investment was in Paytner as part of their Seed VC - II on July 7, 2020.

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Yusuke Sato Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

7/29/2020

Seed VC - II

Paytner

$1.24M

No

3

5/22/2020

Seed VC

Luup

$3.21M

Yes

4

1/30/2020

Series A

Mellia Cosmetics

Yes

2

10/23/2019

Seed VC

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10

9/26/2019

Seed VC

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10

Date

7/29/2020

5/22/2020

1/30/2020

10/23/2019

9/26/2019

Round

Seed VC - II

Seed VC

Series A

Seed VC

Seed VC

Company

Paytner

Luup

Mellia Cosmetics

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Amount

$1.24M

$3.21M

New?

No

Yes

Yes

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Co-Investors

Sources

3

4

2

10

10

Yusuke Sato Portfolio Exits

2 Portfolio Exits

Yusuke Sato has 2 portfolio exits. Their latest portfolio exit was Lovegraph on March 22, 2022.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

3/22/2022

Acquired

$99M

2

7/11/2018

Corporate Majority

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$99M

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10

Date

3/22/2022

7/11/2018

Exit

Acquired

Corporate Majority

Companies

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Valuation

$99M

$99M

Acquirer

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Sources

2

10

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