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Venture Capital
kairosventures.com

Investments

70

Portfolio Exits

5

Funds

14

About Kairos Ventures

Kairos Ventures is a venture capital firm investing in scientific discoveries and commercializing them into viable businesses. The firm was founded in 2015 and is based in Beverly Hills, California.

Headquarters Location

9440 S. Santa Monica Blvd Suite 710

Beverly Hills, California, 90210,

United States

310-271-1866

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Latest Kairos Ventures News

Vivodyne Closes $38 Million Seed Financing Led by Khosla Ventures

Nov 28, 2023

November 22, 2023 PHILADELPHIA–( BUSINESS WIRE )– Vivodyne , a biotech that discovers and develops more effective drugs by testing them on lab-grown human organs, today announced the close of $38 million in total seed financing, led by Khosla Ventures, with participation from Kairos Ventures, CS Ventures, MBX Capital, and Bison Ventures. The funding will advance Vivodyne’s discovery pipeline and clinically predictive AI stack, which identifies novel therapeutic targets and predicts patient responses to new drugs by testing directly on lab-grown human organ tissues. Vivodyne has bioengineered over 20 types of human organ tissues that mimic native human physiology and function to accurately capture the effects of new therapies and predict patient outcomes at the cellular, tissue, organ, and systemic scale. One of the main bottlenecks in drug development is the inability to gather human-predictive data that is realistic, scalable, and reproducible. Vivodyne’s transformative approach for drug discovery produces patient-level human results before a drug is ever tested in clinical trials. The company’s platform can cultivate, dose, and analyze more than 10,000 individual human tissues at a time using robotic automation, allowing the production of vast human datasets that will power the next generation of human-trained AI for drug discovery. Importantly, their platform’s ability to create human data overcomes the key obstacle of AI-driven drug discovery: the unavailability of large, high-quality human datasets for AI training, and the overreliance on simple cell culture to fill this void. “We’re thrilled to have Khosla Ventures lead this funding round, which accelerates the development of our AI platform that enables the generation of predictive human data before therapeutics enter clinical trials,” said Andrei Georgescu, CEO and Co-Founder of Vivodyne. “By combining the principles of organoids and organs-on-chips, we’ve created a new class of lifelike, lab-grown human organs. We use these lab-grown human test subjects to discover and develop new therapies for human diseases. The result is huge amounts of complex human data—larger than you could get from any clinical trial—and we train multimodal models on this data to predict and improve the safety and efficacy of new drugs. This breakthrough not only enhances the predictive accuracy of AI in drug development, but also promises to significantly improve the success rates of AI-generated drugs, setting a new standard in the field.” “By testing drugs and life-saving biologics directly on these realistic human tissues at an unprecedented scale and resolution, we can improve the success rates of therapeutics entering clinical trials,” said Alex Morgan, Partner at Khosla Ventures. “Vivodyne’s technology bridges the gap between preclinical R&D and human clinical trials, while automating every step of the testing pipeline, from growing tissues, dosing, sampling and imaging, to analyzing data. The ability to screen and develop new potential lifesaving therapies, testing thousands at a time on functionally realistic human tissues on Vivodyne’s automated platform, is a major step forward for the pharmaceutical industry.” “The next frontier of therapeutics development rests on achieving greater preclinical certainty before drugs enter clinical trials. Biopharma companies face a pivotal challenge when years of research and significant financial investment confront the unpredictability of clinical trial outcomes and it doesn’t have to be a nailbiter in the eleventh hour waiting for those results. This is biotech’s biggest challenge and our critical focus,” said Susan Billings, Chief Commercial Officer, Vivodyne. “Our platform enables the collection of invaluable human data from early discovery to post-approval — faster, at larger scale, with far more human predictability than animal studies. By producing human data from the outset, we’re identifying and validating novel targets, and significantly mitigating risk prior to clinical trials. For approved therapies, we’re expanding their impact through the discovery of new indications and enhancing patient care.” “What truly sets Vivodyne apart is the seamless integration of life-like, functional lab-grown human tissues, best-in-class robotics, and a strong AI stack — which comes together with the singular focus of generating vast volumes of predictive, preclinical human data,” said Alex Andrianopoulos, Chief R&D Officer at Kairos Ventures. “The most important aspect is how these pieces all converge to produce huge quantities of predictive, preclinical human data that Vivodyne’s AI pipelines can harness to create better and safer drugs more quickly.” Vivodyne has used its AI platform to design and improve many modalities of drugs, from small molecules, to biologics including antibodies and antibody-drug conjugates, to mRNA-bearing lipid nanoparticles, and cell therapies. The company currently has collaborations with the majority of the top 10 large pharma companies, and the Co-Founders’ work has been published in  Science ,  Nature Methods ,  Nature Medicine , and countless other high-impact publications leading up to Vivodyne’s formation. About Vivodyne Vivodyne is a biotechnology company that accelerates the development of more effective medicines by testing on thousands of lifelike, lab-grown human organ tissues at a time. Robots are used to grow and experiment on lab-grown human organs at massive scale, creating datasets of unparalleled realism and breadth to power a predictive AI platform technology. Vivodyne was founded by University of Pennsylvania bioengineers Andrei Georgescu and Dan Huh. For more information, visit  https://vivodyne.com . Follow us  @vivodyne .

Kairos Ventures Investments

70 Investments

Kairos Ventures has made 70 investments. Their latest investment was in Vivodyne as part of their Seed VC - II on November 11, 2023.

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Kairos Ventures Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

11/22/2023

Seed VC - II

Vivodyne

$38M

No

4

11/7/2023

Series E

Foldax

$7M

No

1

2/28/2023

Seed VC - II

PteroDynamics

$7.5M

No

6

1/26/2023

Series B - III

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$99M

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10

10/19/2022

Series C

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$99M

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10

Date

11/22/2023

11/7/2023

2/28/2023

1/26/2023

10/19/2022

Round

Seed VC - II

Series E

Seed VC - II

Series B - III

Series C

Company

Vivodyne

Foldax

PteroDynamics

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Amount

$38M

$7M

$7.5M

$99M

$99M

New?

No

No

No

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Co-Investors

Sources

4

1

6

10

10

Kairos Ventures Portfolio Exits

5 Portfolio Exits

Kairos Ventures has 5 portfolio exits. Their latest portfolio exit was Novosteo on May 10, 2022.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

5/10/2022

Acquired

$99M

3

10/15/2021

Acquired

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$99M

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10

9/22/2021

Acquired

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$99M

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10

4/15/2021

Acquired

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$99M

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10

7/15/2020

Acquired

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$99M

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10

Date

5/10/2022

10/15/2021

9/22/2021

4/15/2021

7/15/2020

Exit

Acquired

Acquired

Acquired

Acquired

Acquired

Companies

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Valuation

$99M

$99M

$99M

$99M

$99M

Acquirer

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Sources

3

10

10

10

10

Kairos Ventures Fund History

14 Fund Histories

Kairos Ventures has 14 funds, including Kairos Venture Partners III.

Closing Date

Fund

Fund Type

Status

Amount

Sources

6/13/2022

Kairos Venture Partners III

$58M

6

5/6/2022

Kairos Ventures ESG One

$10.73M

1

12/16/2020

Kairos-Actuate SPV

$1.69M

1

9/16/2020

Kairos SPV Fund

$99M

10

8/21/2020

Kairos-FD SPV

$99M

10

Closing Date

6/13/2022

5/6/2022

12/16/2020

9/16/2020

8/21/2020

Fund

Kairos Venture Partners III

Kairos Ventures ESG One

Kairos-Actuate SPV

Kairos SPV Fund

Kairos-FD SPV

Fund Type

Status

Amount

$58M

$10.73M

$1.69M

$99M

$99M

Sources

6

1

1

10

10

Kairos Ventures Team

4 Team Members

Kairos Ventures has 4 team members, including current Founder, Chief Executive Officer, James T. Demetriades.

Name

Work History

Title

Status

James T. Demetriades

Founder, Chief Executive Officer

Current

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Name

James T. Demetriades

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Work History

Title

Founder, Chief Executive Officer

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Status

Current

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