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healthlinkcapital.com

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About Healthlink

The firm is a China-based, entrepreneur-backed, healthcare-focused global venture investor. They typically invest in novel therapeutics and medtech companies across all clinical and developmental stages, many of whom seek to explore or expand into the Chinese market in the near future but lack a trusted, knowledgeable, and interest-fully-aligned advisor.

Healthlink Headquarter Location

n/a

Beijing, Beijing, 101300,

China

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Research containing Healthlink

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CB Insights Intelligence Analysts have mentioned Healthlink in 1 CB Insights research brief, most recently on Mar 11, 2021.

Latest Healthlink News

Sprifermin maintains long-term cartilage structural improvements in knee osteoarthritis

Jun 22, 2021

Disclosures: The researchers report funding from Merck KGaA and Billerica. Eckstein reports being an employee and co-owner of Chondrometrics GmbH, as well as grants and consulting fees from Merck KGaA, Samumed LLC, AbbVie, Bioclinica, Orthotrophix, Kolon TissueGene, Servier, Roche, Galapagos, Novartis, ICM and Healthlink. Please see the study for all other authors’ relevant financial disclosures. ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Please try again later. If you continue to have this issue please contact customerservice@slackinc.com . Back to Healio Improvements in articular cartilage thickness among patients with knee osteoarthritis who received sprifermin, versus placebo, during the FORWARD trial were maintained over a 3.5- to 4-year follow-up period, according to data. “There is an urgent need for disease-modifying osteoarthritis drugs (DMOADs) that improve symptoms and inhibit structural disease progression,” Felix Eckstein, MD, of Paracelsus Medical University, in Salzburg, Austria, and colleagues wrote in Annals of the Rheumatic Diseases. “Many DMOAD trials have had limited success or yielded negative results, with the heterogeneous nature of OA and insufficient trial follow-up times being potential contributors.” Improvements in articular cartilage thickness among patients with knee OA who received sprifermin, versus placebo, during the FORWARD trial were maintained over a 3.5- to 4-year follow-up period, according to data. Source: Adobe Stock “FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) was a 5-year, randomized clinical trial that evaluated the efficacy and safety of sprifermin among 549 patients with symptomatic radiographic knee OA,” they added. “The 2-year and 3-year data were reported recently: Dose-dependent modification of [total femorotibial joint (TFTJ)] cartilage thickness with sprifermin was demonstrated at years 2 and 3, and a mean difference of 0.05mm in TFTJ cartilage thickness between the highest sprifermin dose (100µg every 6 months (q6mo); 0.03mm gain) and placebo (0.02mm loss) was observed.” To report on the long-term structural and symptomatic efficacy and safety of sprifermin in the FORWARD trial, as well as in a “subgroup at risk” — featuring patients in FORWARD with narrower medial or lateral minimum joint space width and higher pain on the Western Ontario and McMaster Universities Osteoarthritis Index than the overall study population — Eckstein and colleagues reported findings up to year 5, or 3.5 to 4 years after the last sprifermin treatment. Participants in the multicenter, randomized, double-blind, placebo-controlled trial were randomly assigned to receive intra-articular sprifermin 100µg or 30µg every 6 or 12 months, or placebo, for 18 months. The “subgroup at risk” population included 161 participants with a baseline minimum radiographic joint space width of 1.5 mm to 3.5 mm, and a WOMAC pain score of 40 to 90. A total of 378 patients completed the 5-year follow-up. According to the researchers, sprifermin demonstrated a significant dose response in total femorotibial joint cartilage thickness (P < .001), as well as a 0.05mm mean difference with the 100-µg dose given every 6 months, compared with placebo (95%CI, 0- 0.1), sustained to year 5. In addition, WOMAC pain scores improved approximately 50% from baseline in all groups. No participants who received 100µg every 6 months underwent replacement of the treated knee. Regarding safety, 96% to 98% of patients treated with sprifermin, and 98% of those who received a placebo, reported adverse events. Most adverse events were mild, moderate or considered unrelated to treatment, the researchers wrote. Less than 10% of participants withdrew from the study due to adverse events. In the subgroup at risk, differentiation in WOMAC pain between sprifermin 100µg every 6 months and placebo at year 3 was maintained to year 5 (–10.08; 95%CI –25.68 to 5.53). “DMOADs that not only alleviate symptoms but also modify structure are an important and unmet clinical need for knee OA,” Eckstein and colleagues wrote. “Sufficient follow-up in DMOAD trials may be necessary to demonstrate that the structural benefit of a DMOAD is maintained and that structure modification eventually translates into clinical benefit. FORWARD is the longest DMOAD study reported to date.” “The results of the current analyses show that the efficacy of sprifermin, as measured by both the dose-effect and the mean difference versus placebo in TFTJ cartilage thickness at year 2, was maintained up to year 5, that is, for at least 3.5 years post-active treatment,” they added. “These findings suggest that intra-articular sprifermin has a sustained effect on articular cartilage modification in patients with knee OA, with no detectable systemic exposure or new safety signals observed up to year 5.” Read more about

Healthlink Team

3 Team Members

Healthlink has 3 team members, including current President, John Qiu.

Name

Work History

Title

Status

Wilson Zhu

Founder

Current

John Qiu

President

Current

Ivo Nelson

Chief Executive Officer

Former

Name

Wilson Zhu

John Qiu

Ivo Nelson

Work History

Title

Founder

President

Chief Executive Officer

Status

Current

Current

Former

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