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Venture Capital
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Investments

74

Portfolio Exits

36

Funds

2

About EcoR1 Capital

EcoR1 Capital is a fundamental biotechnology-focused investment advisory firm.

EcoR1 Capital Headquarter Location

409 Illinois Street

San Francisco, California, 94158,

United States

415-754-3517

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Expert Collections containing EcoR1 Capital

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Find EcoR1 Capital in 2 Expert Collections, including Vitamin & Supplement Startups.

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Vitamin & Supplement Startups

237 items

S

Synthetic Biology

382 items

Latest EcoR1 Capital News

ReCode Therapeutics to Expand Next-Generation Delivery Platform and Diversify Genetic Medicines Pipeline with Oversubscribed Series B Financing Totaling $200M

Jun 29, 2022

– Series B extension co-led by AyurMaya, an affiliate of Matrix Capital Management, and Leaps by Bayer, with participation from Amgen Ventures. – – Proceeds to expand and diversify platform and pipeline to include mRNA and gene correction therapeutics for central nervous system, lung, liver, and oncology indications – – Dr. Alan Colowick from Matrix Capital Management and Rakhshita Dhar from Leaps by Bayer to join board of directors – June 29, 2022 06:00 AM Eastern Daylight Time MENLO PARK, Calif.--( BUSINESS WIRE )-- ReCode Therapeutics , a genetic medicines company using superior delivery to power the next wave of messenger RNA (mRNA) and gene correction therapeutics, today announced the close of a Series B extension financing round, co-led by new investors, Leaps by Bayer, the impact investment unit of Bayer AG, AyurMaya, an affiliate of Matrix Capital Management, and with participation from Amgen Ventures. With the additional $120M in new financing, the company has secured a total of $200M in Series B funding. In connection with the financing, Alan Colowick, M.D., M.P.H., managing director of Matrix, and Rakhshita Dhar, senior director of Venture investments Health at Leaps by Bayer, will join ReCode’s Board of Directors. “At AyurMaya, we help build companies that have the potential to transform the therapeutic landscape for patients. ReCode has an impressive combination of groundbreaking science, a highly accomplished leadership team and investor base, and the opportunity to have an immense impact on accelerating precision genetic medicines through delivery to disease-relevant cells,” said Alan Colowick, M.D., M.P.H, Matrix Capital Management. “I am delighted to join ReCode’s Board during this important growth trajectory for the company and am eager to work with the leadership team to expand ReCode’s next generation genetic medicines delivery platform and diversify its pipeline.” The initial Series B financing announced in October 2021 was co-led by Pfizer Ventures and EcoR1 Capital and included Sanofi Ventures, Orbimed, Vida Ventures, MPM Capital, Colt Ventures, Hunt Technology Ventures L.P., Osage University Partners, Tekla Capital Management LLC, Superstring Capital, and NS Investment. Proceeds from the financing will be used to fund the diversification of ReCode’s pipeline into central nervous system (CNS), liver, and oncology indications, while continuing to advance ReCode’s lead mRNA programs for primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) into the clinic. The funds also will be used to advance development of ReCode’s platform to deliver a wider range of genetic medicine cargoes, including additional gene correction modalities and small interfering RNA (siRNA) therapies, to a wider range of target cell types in a predictable and programmable fashion. “The successful administration of billions of doses of mRNA COVID-19 vaccines, and continued progress with novel RNA and gene correction therapeutics, have catapulted us into a new era of possibility for genetic medicines. We are harnessing that potential with our novel selective organ targeting (SORT) lipid nanoparticle (LNP) delivery platform which is engineered with unique properties to enable delivery of genetic therapeutics directly to the organs and cells most impacted by disease, offering improved efficacy and potency. This potentially game-changing precision medicine technology creates vast possibilities for genetic medicines which have been limited by current technologies,” said Shehnaaz Suliman, M.D., MBA, M.Phil., chief executive officer and board member, ReCode Therapeutics. “With the infusion of new capital and the addition of AyurMaya, an affiliate of Matrix Capital Management, and Leaps by Bayer to our high-caliber board, we are confident that our team will successfully drive ReCode’s mission to develop new precision genetic medicines enabled by superior delivery.” The capability to precisely target specific organs and cell types is important for maximizing the efficacy of genetic medicines and limiting potential adverse effects. Additionally, as evidenced with the mRNA COVID vaccines and novel RNA and gene correction therapeutics, LNP packaging enables redosing. For people with genetic diseases such as CF that require potentially lifelong therapy, this means LNP delivered therapeutics can be administered repeatedly over time, potentially without significant immunogenicity. “The ability to directly target specific organs and cells beyond the liver remains a key challenge for genetic medicines,” said Juergen Eckhardt, head of Leaps by Bayer. “At Leaps by Bayer, we strongly focus on finding breakthrough solutions that have the potential to make a meaningful difference for people with rare genetic diseases, and we believe ReCode is a unique company in our industry whose innovations have the potential to fundamentally shift an entire area of genetic medicine.” In May 2022 , ReCode presented preclinical data from its two lead programs in PCD and CF at the American Thoracic Society (ATS) 2022 International Conference . These data demonstrated that selective organ targeting (SORT) LNP-formulated therapeutic candidates for PCD and CF can be precisely delivered directly to disease-relevant cells without significant exposure to other tissue, effectively releasing the encapsulated genetic cargo, and expressing the correct proteins at relevant levels. The company plans to advance to investigational new drug (IND) filings for PCD and CF in late 2022 and mid-2023, respectively. About the SORT LNP Platform ReCode is differentiated by its first-in-class modular genetic medicines delivery platform. The company’s selective organ targeting (SORT) lipid nanoparticle technology (LNP) platform is the foundation for its pipeline. Pioneered by co-founder Professor Daniel J. Siegwart, Ph.D., of the University of Texas, and described by Nature as one of the “Seven Technologies to Watch in 2022,” ReCode’s SORT LNP platform is an innovation beyond the lipid delivery system used by the mRNA COVID vaccines and novel RNA and gene correction therapeutics. LNPs are used to package and deliver genetic cargo such as mRNA. When delivered into the blood, first-generation LNPs primarily are taken up by the liver, which limits their utility for broad therapeutic applications. ReCode’s SORT LNPs are engineered with a biochemically distinct fifth lipid to help the body “sort” and direct the LNPs to other targeted organs such as the lung and spleen, with the ability to bypass the liver, if desired. Beyond its highly selective targeting capability, ReCode’s SORT LNP platform is further distinguished by its versatility in both mode of administration (including IV, inhaled, subcutaneous, intramuscular, and intrathecal), and the diversity of genetic cargo that can be delivered (including mRNA, siRNA, DNA, gene correction components and mixed cargoes). Together, these qualities offer vast opportunities to address a wide range of unmet medical needs through a precision medicine approach that delivers the right medicine to the right organs and cells using the optimal mode of administration. About ReCode Therapeutics ReCode Therapeutics is a genetic medicines company using superior delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s selective organ targeting (SORT) lipid nanoparticle (LNP) platform is a next-generation, genetic medicines technology that enables precise delivery to target organs and cells beyond the liver. The SORT LNP platform is the foundation for ReCode’s pipeline of disease-modifying mRNA and gene correction therapeutics. ReCode’s lead programs are focused on primary ciliary dyskinesia and cystic fibrosis. ReCode is leveraging its SORT LNP platform and nucleic acid technologies to expand its pipeline with therapeutics that use mRNA-mediated replacement and gene correction in target organs with precision targeting of disease-relevant cells. For more information, visit www.recodetx.com and follow us on Twitter @ ReCodeTx and on LinkedIn . Contacts

EcoR1 Capital Investments

74 Investments

EcoR1 Capital has made 74 investments. Their latest investment was in Dewpoint Therapeutics as part of their Series C on February 2, 2022.

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EcoR1 Capital Investments Activity

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EcoR1 Capital Portfolio Exits

36 Portfolio Exits

EcoR1 Capital has 36 portfolio exits. Their latest portfolio exit was Affinivax on May 31, 2022.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

5/31/2022

Acquired

$99M

6

6/11/2021

IPO

$99M

Public

1

5/28/2021

IPO

$99M

Public

9

2/10/2021

Reverse Merger

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$99M

Subscribe to see more

10

12/4/2020

IPO

Subscribe to see more

$99M

Subscribe to see more

10

Date

5/31/2022

6/11/2021

5/28/2021

2/10/2021

12/4/2020

Exit

Acquired

IPO

IPO

Reverse Merger

IPO

Companies

Subscribe to see more

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Valuation

$99M

$99M

$99M

$99M

$99M

Acquirer

Public

Public

Subscribe to see more

Subscribe to see more

Sources

6

1

9

10

10

EcoR1 Capital Fund History

2 Fund Histories

EcoR1 Capital has 2 funds, including EcoR1 Venture Opportunity Offshore Fund.

Closing Date

Fund

Fund Type

Status

Amount

Sources

5/7/2020

EcoR1 Venture Opportunity Offshore Fund

$5.5M

2

10/9/2019

EcoR1 Venture Opportunity Fund

Subscribe to see more

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$99M

10

Closing Date

5/7/2020

10/9/2019

Fund

EcoR1 Venture Opportunity Offshore Fund

EcoR1 Venture Opportunity Fund

Fund Type

Subscribe to see more

Status

Subscribe to see more

Amount

$5.5M

$99M

Sources

2

10

EcoR1 Capital Team

3 Team Members

EcoR1 Capital has 3 team members, including current Founder, Managing Director, Oleg Nodelman.

Name

Work History

Title

Status

Oleg Nodelman

BVF Partners

Founder, Managing Director

Current

Scott Perlen

Sheffield Asset Management Company, GCM Grosvenor, Sunrise Capital Partners, and Bank of America

Chief Financial Officer

Current

Sarah Marriott

Chief Operating Officer, Chief Compliance Officer

Current

Name

Oleg Nodelman

Scott Perlen

Sarah Marriott

Work History

BVF Partners

Sheffield Asset Management Company, GCM Grosvenor, Sunrise Capital Partners, and Bank of America

Title

Founder, Managing Director

Chief Financial Officer

Chief Operating Officer, Chief Compliance Officer

Status

Current

Current

Current

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