Predict your next investment

Incubator/Accelerator
FINANCIAL | Investment Firms & Funds

See what CB Insights has to offer

Investments

5

About COVID-19 Therapeutics Accelerator

COVID-19 Therapeutics Accelerator is launched by Bill & Melinda Gates Foundation, Wellcome and Mastercard to speed development and access to therapies for COVID-19.

COVID-19 Therapeutics Accelerator Headquarter Location

Washington,

United States

Predict your next investment

The CB Insights tech market intelligence platform analyzes millions of data points on venture capital, startups, patents , partnerships and news mentions to help you see tomorrow's opportunities, today.

Research containing COVID-19 Therapeutics Accelerator

Get data-driven expert analysis from the CB Insights Intelligence Unit.

CB Insights Intelligence Analysts have mentioned COVID-19 Therapeutics Accelerator in 1 CB Insights research brief, most recently on Apr 9, 2020.

Latest COVID-19 Therapeutics Accelerator News

Moonshot initiative to develop affordable COVID-19 antivirals gets funding boost

Sep 28, 2021

The COVID Moonshot, a non-profit, open-science consortium of scientists from around the world dedicated to the discovery of globally affordable and easily-manufactured antiviral drugs against COVID-19 and future viral pandemics has received key funding of £8 million from the Wellcome Trust, on behalf of the Covid-19 Therapeutics Accelerator. 'Faced with global vaccine inequality and the rapid spread of variants of concern, the need for easily-accessible antiviral therapeutics to treat people with COVID-19 is as pressing as ever, especially in low- and middle-income countries,' said Annette von Delft, Translational Scientist at the University of Oxford and NIHR Oxford Biomedical Research Centre (BRC). 'Most of the research and funding efforts early in the pandemic focused predominantly on repurposing of existing small molecule drugs and the more rapid development of novel monoclonal antibodies. Now, with the realization that COVID-19 will be a global issue for the foreseeable future we urgently need to develop novel antiviral therapeutics. We are therefore thrilled to receive this critical funding from Wellcome and hope it can lead to more support,' said Alpha Lee, Chief Scientific Officer at PostEra and Faculty Member at the University of Cambridge. The Moonshot started as a spontaneous virtual collaboration in March 2020. As countries locked down, a group of scientists, academics, pharmaceutical research teams and students began a worldwide, twitter-fuelled race against the clock to identify new molecules that could block SARS-CoV-2 infection and develop pills that would be readily available to the most vulnerable communities. The University of Oxford, the NIHR Oxford BRC and Diamond Light Source, the UK's national synchrotron science facility, have been key players in progressing the non-profit, open-science idea and early drug discovery effort of the COVID Moonshot initiative. Close collaboration between them and other contributors around the world enabled the rapid development of promising lead compounds. The appointment of translational scientists working on pre-clinical small molecule drug development by the Oxford BRC prior to the COVID pandemic has been crucial for the success of the project. Annette von Delft has been leading the pre-clinical cellular assays and translational efforts of the Moonshot consortium over the last year. She has been instrumental in securing the £8m Wellcome Trust award in close partnership with the Drugs for Neglected Diseases initiative (DNDi) and will be deputy lead on the pre-clinical development of the oral SARS-CoV-2 MPro inhibitor. MPro is key protease enzyme of a coronavirus that speeds up the breakdown of proteins. Ultimately more than 150 scientists - including dozens of students who put their own projects on hold – joined Moonshot to crowdsource ideas for molecular compounds, model them and evaluate them in-vitro against the virus. Their goal: a safe, globally affordable, not-for-profit oral treatment for COVID-19 and related viral pandemics. 'Open drug discovery efforts are invariably super slow – ours has been an express train on tracks we have laid down as we go,' wrote Frank von Delft, Professor of Structural Chemical Biology at the University of Oxford and Principal Beamline Scientist at Diamond Light Source, in a comment published in June in Nature. 'It is a way of working none of us realised was possible.' Collaborators of the Moonshot project include academic and industrial groups such as Diamond Light Source; the Weizmann Institute of Science (Israel); the Nuffield Department of Medicine at the University of Oxford (UK); PostEra (US/UK); the Memorial Sloan Kettering Cancer Center (US); various drug discovery consultants including MedChemica Ltd (UK), Thames Pharma Partners (US), and Compass Business Partners (UK); and the Switzerland-based DNDi, which is taking the lead in coordinating the Wellcome-funded drive towards the clinic. Thanks to this unprecedented collaboration, rapid progress has been made and the team now aims to identify pre-clinical candidate molecules by the end of 2021 – compounds that will be simple to manufacture in the form of pills and which will exert an anti-viral effect via potent inhibition of the main protease (MPro) of the SARS-CoV-2 virus. The funding from Wellcome is vital as the project enters a phase there the molecules are amended, optimised and tested to develop them into a safe treatment. From its inception, this project has focused on the needs of low- and middle-income countries and the most vulnerable communities, by striving to identify drugs that remove the need of cold chain or injection, and by ensuring that the results are equitably accessible,' said Ben Perry, Discovery Open Innovation Leader at DNDi. 'The project is based firmly in an open science environment and prioritized simplicity of synthesis of the future drugs, in order to facilitate manufacturing by any interested producer.' Nir London, Senior Scientist at the Weizmann Institute of Science, added: 'If drug discovery efforts that were launched during the 2003 SARS epidemic had persevered and had been funded to completion, relevant anti-coronavirus drugs would have been more readily available when COVID-19 hit. 'Now is the time to plan for the future. In addition to addressing this current pandemic, which is not showing signs of slowing, we want to develop one or more novel pan-coronavirus antiviral molecule for future outbreaks. We also want to provide an open platform to accelerate the response time when new pandemics arise.' All the generated discovery scientific data and the general learnings of the project will be put in the public domain. Moonshot data is already available online to enable others to freely build on its work; the project has already generated over 50% of known structural information on the main protease, a key protein in SARS-CoV-2. The first clinical trials are expected in 2022. Latest

COVID-19 Therapeutics Accelerator Investments

5 Investments

COVID-19 Therapeutics Accelerator has made 5 investments. Their latest investment was in Almac Group as part of their Grant - II on November 11, 2020.

CBI Logo

COVID-19 Therapeutics Accelerator Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

11/25/2020

Grant - II

Almac Group

$0.5M

Yes

1

5/12/2020

Grant

Subscribe to see more

$99M

Subscribe to see more

10

3/31/2020

Grant - III

Subscribe to see more

$99M

Subscribe to see more

10

3/31/2020

Grant

Subscribe to see more

$99M

Subscribe to see more

10

3/31/2020

Grant - III

Subscribe to see more

$99M

Subscribe to see more

10

Date

11/25/2020

5/12/2020

3/31/2020

3/31/2020

3/31/2020

Round

Grant - II

Grant

Grant - III

Grant

Grant - III

Company

Almac Group

Subscribe to see more

Subscribe to see more

Subscribe to see more

Subscribe to see more

Amount

$0.5M

$99M

$99M

$99M

$99M

New?

Yes

Subscribe to see more

Subscribe to see more

Subscribe to see more

Subscribe to see more

Co-Investors

Sources

1

10

10

10

10

CB Insights uses Cookies

CBI websites generally use certain cookies to enable better interactions with our sites and services. Use of these cookies, which may be stored on your device, permits us to improve and customize your experience. You can read more about your cookie choices at our privacy policy here. By continuing to use this site you are consenting to these choices.