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brightlandsventurepartners.com

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Investments

54

Portfolio Exits

8

Funds

4

About Brightlands Venture Partners

Brightlands Venture Partners is an independent regional venture capital fund manager in the south of the Netherlands (Limburg) with a focus on smart materials, life sciences, agrifood and smart services. The firm supports companies which fit in with the ecosystem of the Brightlands campuses.

Brightlands Venture Partners Headquarter Location

Center Court 1026, Brightlands Chemelot Campus Urmonderbaan 22

Geleen, 6167 RD,

Netherlands

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Latest Brightlands Venture Partners News

Stem cell biotech Neuroplast enrolls first patient in Phase II clinical trial of transformative Neuro-Cells® treatment for Traumatic Spinal Cord Injury

Mar 29, 2022

News provided by Share this article Share this article Neuro-Cells® treatment aims to reduce irreversible damage to the central nervous system from secondary inflammation following trauma The randomized, placebo-controlled, international multi-center Phase II clinical trial will determine efficacy for treatment of Traumatic Spinal Cord Injury (TSCI) Spanish and Danish authorities approved a combined Phase II/III clinical trial that enables a faster development path towards the market Positive results from Phase I clinical trial provides a solid foundation for this first therapeutic indication in Europe Neuroplast aims to attract additional funding to expand to other geographies and leverage the potential of the Neuro-Cells® technology platform for Traumatic Brain Injury (TBI) and Frontotemporal Dementia (FTD) GELEEN, Netherlands, March 29, 2022 /PRNewswire/ -- Neuroplast , a Dutch clinical stage biotech, focusing on cell-based treatments for neurodegenerative diseases, has enrolled its first patient in a Phase II clinical trial to evaluate efficacy of its transformative Neuro-Cells® treatment that aims to prevent further damage to the central nervous system after sustaining acute Traumatic Spinal Cord Injury (TSCI). The trial is conducted in collaboration with Hospital Nacional de Parapléjicos in Toledo, Spain. Recently, Neuroplast announced positive clinical Phase I results with Neuro-Cells® for the treatment for TSCI and also secured €10 million (US$11.5M) for the path towards obtaining conditional EMA market approval. Annually, approximately 29,000 people across Europe and the USA suffer from acute TSCI, for which effective treatment is currently unavailable. Patients usually experience life-long disability and dependence, with a negative impact on quality of life. Furthermore, associated costs for society at large are estimated at over €11.4 billion ($13 billion) per year. With the aim of giving back perspective to people that suffer from neurodegenerative diseases, Neuroplast developed Neuro-Cells®, a treatment that uses the patients own stem cells to prevent (further) loss of function during the acute phase after sustaining damage to the spinal cord, to preserve function, mobility and independence. Such combination of a) autologous treatment and b) intrathecal application in c) acute setting is what makes Neuro-Cells® unique. Randomized, placebo-controlled international multi-center study The Phase II clinical trial is conducted by Principal Investigators Antonio Oliviero, MD, PHD and Prof. Jörg Mey from Hospital Parapléjicos in Toledo, Spain. The study is a randomized and placebo-controlled trial, with an early and late intervention cross-over design. The intervention group receives Neuro-Cells® in the sub-acute phase after sustaining trauma, with six months follow-up to their primary endpoints. The placebo group will receive a placebo at first, but will be treated with Neuro-Cells® after the initial six-month follow-up period. The multi-facetted follow-up for both groups include standardized and validated outcome measures on motor and sensory function and multiple blood and cerebrospinal fluid measurements. Antonio Oliviero, MD, PhD, Principal Investigator at Hospital Nacional de Parapléjicos de Toledo, Spain, states, "After having worked in the field of Spinal Cord Injury for almost twenty years, I am happy to contribute to establishing the role of cell transplantation in the functional recovery of individuals with Spinal Cord Injury. I am excited to be a part of this new step in research, together with Neuroplast." The trial will involve 16 patients that will be included six to eight weeks after sustaining trauma to the spinal cord. The trial is conducted under official approval from the Spanish and Danish medical ethical committees Comité de Ética de la Investigación con medicamentos (CEIm) and National Videnskabsetisk Komité (NVK) and the competent authorities Agencia Espańola de Medicamentos y Productos Sanitarios (AEMPS) and the Danish Medicines Agency. These authorities approved a combined Phase II/III approach. This enables a faster path towards the market due to savings in time and a reduced number of required patients to study. Neuroplast CEO, Johannes de Munter, concludes: "The start of this Phase II trial marks another important milestone in our mission to bring back perspective to people who suffer from neurodegenerative diseases for which no effective treatments are available." Neuroplast has secured sufficient funding for the path towards obtaining conditional EMA market approval for the treatment of TSCI. The company is seeking additional funding for other geographies, and to explore broader potential of the Neuro-Cells® technology platform for Traumatic Brain Injury and Frontotemporal Dementia. About Traumatic Spinal Cord Injury (TSCI) Acute TSCI causes incurable impairment to the spinal cord, affecting approximately 12,000 people across Europe and 17,000 across the USA annually. The damage or trauma interrupts communication of the brain with the body regions below the site of injury. Spinal cord injuries are mainly caused by accidents and - in most of the cases - result in life-long loss of control of motor functions and sensations. After the primary injury to the spinal cord, a cascade of events leads to progressive loss of tissue which may further deteriorate the patient's prognosis. Current treatment approaches for TSCI are only symptomatic, leaving the underlying pathophysiology unchanged. TSCI has a serious impact on the quality of life of patients, with severe implications on mobility and loss of independence. In addition, TSCI creates a lifetime financial burden for patients, payors, healthcare systems and societies at large. About Neuro-Cells® Neuro-Cells® is a transformative treatment under GMP in the crucial first phase after sustaining TSCI, during which the irreversible impact of TSCI can be radically reduced. It contains non-substantially manipulated bone marrow-derived hematopoietic and mesenchymal stem cells, manufactured from a patient's own bone marrow (donor and receiver are the same person). Inflammatory inducing components and pathogens are removed during this process. The combination of a) autologous treatment and b) intrathecal application in c) acute setting is what makes Neuro-Cells® unique. About Neuroplast Neuroplast is a Dutch stem cell technology company focusing on fast-track development programs using autologous cell products for treatment of neurodegenerative diseases, with the aim of giving back perspective to people who suffer from those conditions. The company was founded in August 2014 by physician Johannes de Munter and neurologist Erik Wolters. Current funders are Lumana Invest, Brightlands Venture Partners, LIOF and the Netherlands Enterprise Agency. Neuroplast is located at Brightlands Chemelot Campus in The Netherlands. About Hospital de Parapléjicos, Toledo, Spain Hospital Nacional de Parapléjicos de Toledo is the reference public hospital in Spain for the treatment of spinal cord injury, recognized by the Ministry of Health of the Government of Spain. About Lumana Invest Investment company Lumana was established by entrepreneurs and unique due to not having a predetermined investment horizon. The Lumana founders showcase strong commitment to their portfolio companies by actively supporting management in strategic decision making. About Brightlands Venture Partners Brightlands Venture Partners (BVP) is the fund manager of Chemelot Ventures and is a so-called ecosystem investor. BVP invests in companies benefiting from and contributing to the Brightlands campuses in the south of The Netherlands. Other funds under management are BVP Fund IV, Brightlands Agrifood Fund and Limburg Ventures. The funds of BVP focus on sustainability and health; together the funds have made over 40 investments. About LIOF LIOF is the regional development agency for Limburg and supports innovative entrepreneurs with advice, network and financing. Together with entrepreneurs and partners, LIOF is working towards a smarter, more sustainable and healthier Limburg by focusing on the transitions of energy, circularity, health and digitalization. About The Netherlands Enterprise Agency The Netherlands Enterprise Agency operates under the auspices of the Dutch Ministry of Economic Affairs and Climate Policy. It facilitates entrepreneurship, improves collaborations, strengthens positions and helps realize national and international ambitions with funding, networking, know-how and compliance with laws and regulations. Forward looking statements All statements other than statements of historical facts, including the statements about the clinical and therapeutic potential and future clinical milestones of Neuro-CellsÒ, the indications we intend to pursue and our possible clinical or other business strategies, and the timing of these events, are forward-looking statements. Forward-looking statements can be identified by terms such as "believes", "expects", "plans", "potential", "would" or similar expressions and the negative of those terms. These forward-looking statements are based on our management's current beliefs and assumptions about future events and on information currently available to management. Neuroplast B.V. does not make any representation or warranty, express or implied, as to the improper use of this article, accuracy, completeness or updated status of above-mentioned statements. Therefore, in no case whatsoever will Neuroplast B.V. be legally liable or liable to anyone for any decision made or action taken in conjunction with the information and/or statements in this press release or for any related damages. Contact:

Brightlands Venture Partners Investments

54 Investments

Brightlands Venture Partners has made 54 investments. Their latest investment was in Verdify as part of their Seed VC - II on July 7, 2022.

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Brightlands Venture Partners Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

7/1/2022

Seed VC - II

Verdify

$0.83M

No

1

1/18/2022

Seed VC

Mane Biotech

$1.93M

Yes

Undisclosed Angel Investors

1

1/14/2022

Seed VC

PectCof

$2.28M

Yes

2

12/13/2021

Seed VC

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$99M

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10

11/17/2021

Series B

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$99M

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10

Date

7/1/2022

1/18/2022

1/14/2022

12/13/2021

11/17/2021

Round

Seed VC - II

Seed VC

Seed VC

Seed VC

Series B

Company

Verdify

Mane Biotech

PectCof

Subscribe to see more

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Amount

$0.83M

$1.93M

$2.28M

$99M

$99M

New?

No

Yes

Yes

Subscribe to see more

Subscribe to see more

Co-Investors

Undisclosed Angel Investors

Sources

1

1

2

10

10

Brightlands Venture Partners Portfolio Exits

8 Portfolio Exits

Brightlands Venture Partners has 8 portfolio exits. Their latest portfolio exit was Polyscope Polymers on January 31, 2022.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

1/31/2022

Acquired

$99M

3

9/26/2019

Acquired

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$99M

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10

6/3/2019

Shareholder Liquidity

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$99M

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10

1/5/2018

Acq - P2P

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$99M

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10

5/31/2017

Acquired

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$99M

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10

Date

1/31/2022

9/26/2019

6/3/2019

1/5/2018

5/31/2017

Exit

Acquired

Acquired

Shareholder Liquidity

Acq - P2P

Acquired

Companies

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Valuation

$99M

$99M

$99M

$99M

$99M

Acquirer

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Sources

3

10

10

10

10

Brightlands Venture Partners Fund History

4 Fund Histories

Brightlands Venture Partners has 4 funds, including BVP Fund IV.

Closing Date

Fund

Fund Type

Status

Amount

Sources

4/15/2021

BVP Fund IV

$53.9M

1

10/26/2018

Brightlands Agrifood Ventures

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$99M

10

3/31/2014

Chemelot Ventures

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$99M

10

1/1/2004

Limburg Ventures

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10

Closing Date

4/15/2021

10/26/2018

3/31/2014

1/1/2004

Fund

BVP Fund IV

Brightlands Agrifood Ventures

Chemelot Ventures

Limburg Ventures

Fund Type

Subscribe to see more

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Status

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Amount

$53.9M

$99M

$99M

Sources

1

10

10

10

Brightlands Venture Partners Team

2 Team Members

Brightlands Venture Partners has 2 team members, including current Managing Partner, Marcel Kloosterman.

Name

Work History

Title

Status

Marcel Kloosterman

Nedermaas Ventures, DSM, and Centrient Pharmaceuticals

Managing Partner

Current

Casper Bruens

Managing Director

Current

Name

Marcel Kloosterman

Casper Bruens

Work History

Nedermaas Ventures, DSM, and Centrient Pharmaceuticals

Title

Managing Partner

Managing Director

Status

Current

Current

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