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CARB-X company logo
Public-Private Partnership
HEALTHCARE | Medical Facilities & Services / Medical Laboratories & Research
carb-x.org

Investments

58

Portfolio Exits

10

Partners & Customers

10

About CARB-X

Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) is a global non-profit partnership accelerating antibacterial products to address drug-resistant bacteria, a leading cause of death around the world. It integrates solutions for the prevention, diagnosis, and treatment of life-threatening bacterial infections. CARB-X's portfolio is a scientifically diverse, early development pipeline of new antibiotics, vaccines, rapid diagnostics, and other products. It was founded in 2016 and is based in Boston, Massachusetts.

Headquarters Location

771e Commonwealth Avenue

Boston, Massachusetts, 02215,

United States

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Latest CARB-X News

Day Zero Diagnostics raises $8.2M from CARB-X

Oct 24, 2022

October 24, 2022 Day Zero Diagnostics announced that it received an $8.2 million award in optional stage funding from CARB-X. The infectious disease diagnostic developer received an initial $6.2 million CARB-X award in May 2020. CARB-X, the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator, aims to accelerate early antibacterial R&D. This would address the rising global threat of drug-resistant bacteria. Day Zero develops whole genome sequencing-based diagnostic technologies. The company designed them to identify both the species and the antibiotic resistance profile of a bacterial pathogen. It does so from a blood sample, within hours. This eliminates the need for a culture. “We greatly appreciate CARB-X’s continued support as we pioneer a new class of infectious disease diagnostics that leverage whole genome sequencing and machine learning to enable rapid identification of pathogens and their antibiotic resistance profile. Day Zero Diagnostics is determined to bend the curve on antibiotic resistance growth by enabling rapid and accurate diagnosis,” said Jong Lee, CEO of Day Zero Diagnostics. “This latest CARB-X award validates the tremendous progress our team of scientists and engineers have made in bringing these novel technologies to maturity and demonstrating the tremendous potential of genome sequencing technology in combating antibiotic resistance. CARB-X’s continued support now focuses on productizing these technologies so we can help fight the global threat of antibiotic resistance.” How Day Zero plans to use the funding Day Zero said that its option stage funding from CARB-X enables a transition into product development. Its ultimate goal remains the launch of an FDA-cleared and CE-marked in-vitro diagnostic instrument and cartridge system. The company is developing the system to provide a sample-to-answer solution. It incorporates the capabilities of the company’s novel technologies, including Blood2Bac. Blood2Bac is a proprietary sample preparation technology for ultra-high enrichment of bacterial DNA from clinical blood samples. Keynome, the Day Zero machine learning algorithm for species identification and resistance profiling, also features. Day Zero also intends to expand its MicrohmDB large-scale database. It combines pathogen genomic sequences with their known antibiotic resistance and susceptibility profiles. “We are pleased to support Day Zero Diagnostics’ development of its rapid infectious disease diagnostic technology,” said Erin Duffy, chief of research and development at CARB-X. “Day Zero’s whole genome sequencing and machine learning technology is a novel approach that could change the way infectious disease is diagnosed, help curb antibiotic resistance, and save lives.” A decade ago, medical device companies often turned to Europe to score initial regulatory approval for new products. Even though the U.S. is a larger market, many companies looked to Europe to win regulatory approval for their medtech innovation efforts. As a result, European patients received access to new therapies an average of two years earlier… […] Avail Medsystems is testing a third-party software integration that it plans to launch in the coming months. Avail executives said they hope it will be the first of many partnerships with medical technology developers of software or algorithms that could be useful in the operating room. Avail CEO Daniel Hawkins expects to launch the software… […] Medical devices ranging from in vitro diagnostic devices to wearable sensors/analyzers/aids are equipped with an ever-growing number of power management ICs, energy management units, and respective power supply circuits. To qualify for the use in medical devices, inductors must both meet the evolving demands as well as basic medical standards. Learn about the applications and… […] Patient-operated medical devices — such as those used in insulin delivery — require a focus on the usability requirements of the less-experienced end user. Philip Remedios, BlackHägen Design User-centered design is critical when developing new medical devices to support distance care. Medtech companies are now specifically designing devices for patient use outside of clinical settings. Digital… […] With healthtech AI investment booming, companies are seeking guidance on when and how to protect that work. Andrew (A.J.) Tibbetts, Greenberg Traurig Can you get intellectual property (IP) for artificial intelligence (AI)? Absolutely. Should you file a patent application? Maybe, but there are alternatives. Should you consider data options? Yes. Is there a standard strategy… […] Medical device usability research and human factors engineering starts with device users, the use environment and user interfaces. Gregory Montalbano, MIDI Medical Product Development Designing a medical device is not a lighthearted or straightforward task. Every design choice during the development process can influence how the device is used, whether it is effective and if… […] Confluent Medical Technologies announced today that it appointed Matthew Eckl as its new chief financial officer (CFO). The Scottsdale, Arizona-based company made Eckl’s appointment effective today. His responsibilities include global financial strategy and financial operations. The company intends for Eckl to lead its accounting, financial planning and analysis, legal and information technology teams. “We are… […] The future of medical device design is in our hands. Here’s what it’ll take to get there. Tony Kaufman, 3M It’s an exciting and challenging time in medical device history. From tracking vital signs to enabling more informed conversations with health professionals, device users can take control of their health in new and powerful ways.… […] Researchers at the Massachusetts Institute of Technology (MIT) developed an unsupervised physical rehabilitation system. MuscleRehab came from researchers at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) and Massachusetts General Hospital (MGH). Together, they combined three ingredients: motion tracking, imaging and virtual reality (VR). The motion tracking captures motion activity. The electrical impedance tomography (EIT)… […] Private equity firm Vance Street Capital said today that it has purchased Mountain Manufacturing Technologies. Terms of the deal were not disclosed. Lino Lakes, Minnesota-based Mountain Manufacturing Technologies is a wire and metal tube supplier for the interventional and advanced surgical markets. Los Angeles-based Vance Street said the acquisition would complement another company in its… […]

CARB-X Investments

58 Investments

CARB-X has made 58 investments. Their latest investment was in Day Zero Diagnostics as part of their Grant - III on October 10, 2022.

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CARB-X Investments Activity

investments chart

Date

Round

Company

Amount

New?

Co-Investors

Sources

10/20/2022

Grant - III

Day Zero Diagnostics

$8.2M

No

2

9/1/2022

Grant

Avails Medical

$1.7M

Yes

1

4/5/2022

Grant - II

Clarametyx Biosciences

$3.89M

Yes

1

6/10/2021

Grant

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$99M

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10

6/1/2021

Grant - IV

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$99M

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10

Date

10/20/2022

9/1/2022

4/5/2022

6/10/2021

6/1/2021

Round

Grant - III

Grant

Grant - II

Grant

Grant - IV

Company

Day Zero Diagnostics

Avails Medical

Clarametyx Biosciences

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Amount

$8.2M

$1.7M

$3.89M

$99M

$99M

New?

No

Yes

Yes

Subscribe to see more

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Co-Investors

Sources

2

1

1

10

10

CARB-X Portfolio Exits

10 Portfolio Exits

CARB-X has 10 portfolio exits. Their latest portfolio exit was MicuRx Pharmaceuticals on August 05, 2022.

Date

Exit

Companies

Valuation
Valuations are submitted by companies, mined from state filings or news, provided by VentureSource, or based on a comparables valuation model.

Acquirer

Sources

8/5/2022

IPO

$99M

Public

1

5/31/2022

Acquired

$99M

6

4/12/2022

Acquired

$99M

2

2/12/2021

IPO

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$99M

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10

8/19/2020

IPO

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$99M

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10

Date

8/5/2022

5/31/2022

4/12/2022

2/12/2021

8/19/2020

Exit

IPO

Acquired

Acquired

IPO

IPO

Companies

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Valuation

$99M

$99M

$99M

$99M

$99M

Acquirer

Public

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Sources

1

6

2

10

10

CARB-X Partners & Customers

10 Partners and customers

CARB-X has 10 strategic partners and customers. CARB-X recently partnered with TAXIS Pharmaceuticals on January 1, 2021.

Date

Type

Business Partner

Country

News Snippet

Sources

1/1/2021

Vendor

United States

Acute Bacterial Skin and Skin Structure Infections Pipeline Landscape Report 2022: Comprehensive Insights About 15+ Companies and 15+ Pipeline Drugs - ResearchAndMarkets.com

In January 2021 , CARB-X , a global partnership led by Boston University , is awarding TAXIS Pharmaceuticals , up to $ 3.2 million in non-dilutive funding to develop Efflux Pump Inhibitors , representing a new drug class designed to address a major mechanism of multi-drug-resistant Pseudomonas aeruginosa bacteria .

1

11/26/2019

Partner

United States

T2 Biosystems’ T2Resistance™ Panel is First Diagnostic to Graduate from CARB-X Portfolio

The partnership with CARB-X is part of Department for Health and Social Care 's Global Antimicrobial Resistance Innovation Fund .

1

4/2/2019

Vendor

United States

Melinta Therapeutics Receives Up to $6.2 Million from CARB-X to Advance Clinical Development of a Novel Antimicrobial to Combat Antibiotic-Resistant Bacteria : Malin PLC

NEW HAVEN , Conn. , May 07 , 2018 -- Melinta Therapeutics , Inc. , a commercial-stage company discovering , developing and commercializing novel antibiotics to treat serious bacterial infections , today announced that it has entered into a partnership with CARB-X , under which Melinta Therapeutics , Inc. will be awarded up to $ 6.2 million to support the development of the company 's investigational pyrrolocytosine compounds .

1

2/25/2019

Vendor

United States

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10

2/4/2019

Vendor

Switzerland

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10

Date

1/1/2021

11/26/2019

4/2/2019

2/25/2019

2/4/2019

Type

Vendor

Partner

Vendor

Vendor

Vendor

Business Partner

Country

United States

United States

United States

United States

Switzerland

News Snippet

Acute Bacterial Skin and Skin Structure Infections Pipeline Landscape Report 2022: Comprehensive Insights About 15+ Companies and 15+ Pipeline Drugs - ResearchAndMarkets.com

In January 2021 , CARB-X , a global partnership led by Boston University , is awarding TAXIS Pharmaceuticals , up to $ 3.2 million in non-dilutive funding to develop Efflux Pump Inhibitors , representing a new drug class designed to address a major mechanism of multi-drug-resistant Pseudomonas aeruginosa bacteria .

T2 Biosystems’ T2Resistance™ Panel is First Diagnostic to Graduate from CARB-X Portfolio

The partnership with CARB-X is part of Department for Health and Social Care 's Global Antimicrobial Resistance Innovation Fund .

Melinta Therapeutics Receives Up to $6.2 Million from CARB-X to Advance Clinical Development of a Novel Antimicrobial to Combat Antibiotic-Resistant Bacteria : Malin PLC

NEW HAVEN , Conn. , May 07 , 2018 -- Melinta Therapeutics , Inc. , a commercial-stage company discovering , developing and commercializing novel antibiotics to treat serious bacterial infections , today announced that it has entered into a partnership with CARB-X , under which Melinta Therapeutics , Inc. will be awarded up to $ 6.2 million to support the development of the company 's investigational pyrrolocytosine compounds .

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Sources

1

1

1

10

10

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