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Corporation
HEALTHCARE | Medical Devices & Equipment / Therapeutic Devices
wiseneuro.com

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Founded Year

2011

Stage

Series C | Alive

Total Raised

$32.77M

Last Raised

$17.61M | 1 yr ago

About WISE

WISE develops novel, highly flexible and stretchable implantable neuromodulation leads for the treatment of different neurological conditions based on its proprietary Supersonic Cluster Beam Implantation (SCBI) technology.

WISE Headquarter Location

Piazza Duse, 2

Milan, 20122,

Italy

+39 0256660143

Latest WISE News

WISE’s Cutting-Edge Cortical Neuromonitoring Electrode Receives CE Mark

May 18, 2021

WISE Cortical Strip is the first electrode with such a high grade of compliance to receive CE Mark The thin and pliable WISE Cortical Strip provides unprecedented conformability to the brain surface for neuromonitoring during brain tumor and epilepsy surgeries WISE’s proprietary Supersonic Technology allows the manufacture of extremely thin, stretchable and conformable electrodes, capable of highly effective stimulation and recording May 18, 2021 03:00 AM Eastern Daylight Time MILAN & BERLIN--( BUSINESS WIRE )--WISE Srl, a medical device company developing next-generation implantable electrodes for neuromonitoring, neuromodulation and brain-machine interfacing (BMI), today announced the CE marking of its WISE Cortical Strip (WCS®), a single use medical device intended to be used on the surface of the brain for intraoperative neurophysiological monitoring (IONM). The WISE Cortical Strip is the first product receiving CE mark within the Company’s WISEneuro® Monitoring product family. The CE mark follows the successful conclusion of the WIN study, a multicentric pre-market clinical study that demonstrated safety, performance and usability of WISE’s device ( NCT03731455 ). The data showed better performance in terms of electrical impedance in physiological conditions of the WISE Cortical Strip compared to other traditional cortical electrodes available on the market. The WISE Cortical Strip can be used both to stimulate (MEP) and record (ECoG and SEP) the brain’s electrical activity, supporting intraoperative monitoring during resection of brain tumors or epileptogenic lesions. Unlike traditional cortical electrodes, which are made of stiff metal discs enclosed in a thick silicone foil, the WISE Cortical Strip is composed of stretchable platinum contacts embedded in a soft and thin film of silicone. As a result, the WISE Cortical Strip is highly ergonomic and conformable to the brain surface. Leveraging the capabilities of WISE’s patented Supersonic Technology, the WISEneuro® Monitoring product family will comprise strips and grids with varying thickness, and with embedded contacts of a wide range of shapes, density, numbers or sizes (from the micro to the macro scale). During intraoperative neuromonitoring, the functional integrity of neural circuits is monitored to minimize neurological damages during surgical lesions resection, thus avoiding or limiting significant post-operative impairments. However, since the brain surface is folded into ridges and grooves, only highly conformable electrodes can fully adhere to the entire brain surface and monitor its functional integrity. After the successful CE approval, the Company is now aiming for FDA clearance of the device. Luca Ravagnan, CEO of WISE said: “The CE mark is a crucial milestone for the company, enabling us to bring the first IONM electrode with extreme compliance to the brain cortex to the European market. With this, we are also officially launching our WISEneuro® Monitoring product family. Our mission is to revolutionize electrode manufacturing utilizing our unique technology, all this to improve treatment quality for patients.” Sandro Ferrari, Director of Operations added: “It has been an exciting journey moving from a lab-scale and radically new technology to a CE marked class III medical device. This approval validates the application of our technology to invasive neuro-electrodes, underpinning our current development of chronic implants for neuromodulation and BMI.” WISE’s unique Supersonic Technology allows the development of extremely thin, pliable and conformable electrodes allowing a very effective stimulation and recording for a wide range of applications. In addition to neuromonitoring, WISE is also active in the field of neuromodulation, developing its WISEneuro® Modulation product family. The first product of this line will be the SCS Expert lead, the first expandable percutaneous paddle lead for Spinal Cord Stimulation that pain therapists and neurosurgeons will be able to implant percutaneously. WISE recently closed a financial round of €15M, led by major European VC funds. The Company also received an EIC Accelerator grant from the European Commission worth €2.3M. For more information, please visit: www.wiseneuro.com -Ends- About WISE WISE Srl has developed a genuinely new generation of electrodes for neuromonitoring, neuromodulation and brain machine interfacing by means of its proprietary Supersonic Technology. Neuromonitoring and neuromodulation require electrodes and leads to be surgically implanted on neural tissues (as for instance the brain and the spinal cord) to apply electrical stimuli or to record the electrical activity. The electrodes produced using WISE’s Supersonic Technology consist of stretchable electronic circuits integrated in very thin elastomeric foils. As a result, WISE’s electrodes are highly ergonomic, conformable, soft and thin, thus allowing great adhesion, minimal invasiveness and excellent adaptability on neural tissues. Founded by a team of material scientists coming from the University of Milan, WISE received initial funding from Agite!, Atlante Seed and Atlante Ventures, b-to-v, HTGF, Principia SGR, New Frontier and private investors, and closed a Series C funding round in 2020 with new investors (CDP Venture Capital SGR, Indaco Ventures I Fund and EUREKA! Venture SGR). Since 2016, the Company established its production plant in Cologno Monzese, Milan, Italy, and has an office in Berlin, Germany. For more information, please visit: www.wiseneuro.com . Contacts

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Research containing WISE

Get data-driven expert analysis from the CB Insights Intelligence Unit.

CB Insights Intelligence Analysts have mentioned WISE in 5 CB Insights research briefs, most recently on Jun 17, 2021.

Expert Collections containing WISE

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

WISE is included in 3 Expert Collections, including Neuroscience.

N

Neuroscience

2,144 items

Companies developing products that monitor, analyze, protect, or otherwise influence the structure/function of the nervous system.

M

Medical Devices

7,424 items

Companies developing medical devices (per the IMDRF's definition of "medical device"). Includes software, lab-developed tests (LDTs), and combination products. Excludes CDMOs/CMOs. *Columns updated as regularly as possible.

B

Bioelectronics

843 items

Companies developing/using technology aimed at detecting, interpreting, interrupting, eliciting, or redirecting electrical signals within the body

WISE Patents

WISE has filed 45 patents.

The 3 most popular patent topics include:

  • Engine technology
  • Artificial intelligence
  • Artificial neural networks
patents chart

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Artificial neural networks, Cardiac arrhythmia, Heart diseases, Health informatics, Artificial intelligence

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