Latest Voci Corporation News
Sep 8, 2023
They used the same model to investigate whether exercise-induced increased levels of irisin affects amyloid beta pathology. To test whether irisin plays a causal role in the link between exercise and reduced amyloid beta, Se Hoon Choi , PhD, and Eun Hee Kim , PhD, both researchers at the Genetics and Aging Research Unit at Massachusetts General Hospital, along with their colleagues, applied irisin to their 3D cell culture model of Alzheimer’s. “First, we found that irisin treatment led to a remarkable reduction of amyloid beta pathology,” said Choi in a press release. “Second, we showed this effect of irisin was attributable to increased neprilysin activity, owing to increased levels of neprilysin secreted from cells in the brain called astrocytes.” For example, they identified a receptor that irisin binds to, triggering the cells to increase neprilysin levels. They also discovered irisin’s binding to this receptor causes reduced signaling of pathways involving two key proteins: extracellular signal-regulated kinase (ERK) and signal activator of transcription 3 (STAT3). Reducing the signaling of ERK and STAT3 is critical for irisin to enhance neprilysin, which fights the brain-damaging amyloid beta. have shown irisin injected into the blood stream of mice can make its way into the brain, creating a new pathway for targeted therapies. “Our findings indicate that irisin is a major mediator of exercise-induced increases in neprilysin levels leading to reduced amyloid beta burden, suggesting a new target pathway for therapies aimed at the prevention and treatment of Alzheimer’s disease,” said Rudolph Tanzi , a senior author of the study and director of the Genetics and Aging Research Unit at Massachusetts General. Ryan Glatt , a senior brain health coach and director of the FitBrain Program at Pacific Neuroscience Institute in California, told Medical News Today the research is still in the early stages and there’s much more work to be done. “Prior studies in adult humans have demonstrated increased levels of irisin as the result of exercise, particularly resistance training, which may mediate some of the benefits of exercise on brain health,” Glatt said. “The exact mechanisms require further elucidation, so studies like these can get us closer to that understanding. More human research is needed and future studies could compare the mediating effects of irisin in comparison to other growth factors, such as insulin-like growth factor-1 (IGF-1) and brain derived neurotrophic factor (BDNF). Glatt added that future research should also seek to clarify what modes of exercise (i.e., aerobic versus resistance training) as well as what intensities and what durations lead to in terms of the concentration of certain myokines such as irisin. “The responses from adults who are cognitively healthy in comparison to those with existing cognitive impairment needs further research, and the cognitive outcomes as the result of the expression of myokines, such as irisin, need to be better understood,” Glatt said. Nick Voci is a doctor of physical therapy at Manchester Physical Therapy in Vermont. Voci told Medical News Today that he works with many people who have Alzheimer’s for various health issues, such as decreased activity tolerance, balance deficits, and/or decreased strength. “While this may be big news as to the ‘why’ exercise helps, in the physical therapy world this just adds to the growing evidence of why we need to continue to promote physical therapy, as well as activity and exercise in general,” Voci said. He added the study may lead doctors to try finding medications to mimic the effect of exercise without actually requiring physical activity. “While this research shows promising results, a lot more research would be needed to show how much of an impact it would make on people with Alzheimer’s and how much would be needed for a preventive effect,” Voci said. “But I would argue that this gives more evidence to the broad spectrum of what exercise can treat. Exercise is medicine.”
Voci Corporation Frequently Asked Questions (FAQ)
Where is Voci Corporation's headquarters?
Voci Corporation's headquarters is located at 1504 Dell Avenue, Campbell.
What is Voci Corporation's latest funding round?
Voci Corporation's latest funding round is Series B.
How much did Voci Corporation raise?
Voci Corporation raised a total of $4.75M.
Who are the investors of Voci Corporation?
Investors of Voci Corporation include Band of Angels, Dawntreader Ventures, Luther King Capital Management Corporation and RBC Capital Markets.