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Founded Year

2000

Stage

Acquired | Acquired

Valuation

$0000 

About Visual Sciences

Visual Sciences was a Software (non-internet/mobile) company based in Herndon, Virginia. Visual Sciences was acquired in 2006.

Visual Sciences Headquarters Location

13450 Sunrise Valley Drive 6th Floor

Herndon, Virginia, 20171,

United States

202-595-0066

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Latest Visual Sciences News

Comparing SPEED and OSDI Questionnaires in a Non-Clinical Sample

Oct 18, 2021

1Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Sindh, Pakistan; 2Civil Hospital, Dow Medical College, Karachi, Sindh, Pakistan Correspondence: Nauman Hashmani Tel +92 21 32781409 Purpose: To compare the performance of OSDI and SPEED questionnaires in a non-clinical sample in Pakistan. Methods: SPEED and OSDI questionnaires were simultaneously administered to a sample of 600 participants in Pakistan with an average age of 31.0 ± 10.1 years. Results: Mean SPEED scores were calculated according to the OSDI categories and were found to be 3.33 ± 3.44, 5.45 ± 3.77, 7.86 ± 4.33, and 9.39 ± 4.56 for the normal, mild, moderate, and severe groups, respectively. Using Cronbach’s alpha, the total OSDI and SPEED scores were calculated to be 0.924 and 0.879, respectively. A receiver operating curve was plotted, and the area under the curve (AUC) was estimated to be 0.791. Using this curve, the cutoff score for the SPEED questionnaire was found to be 4.00 (P Conclusion: The SPEED questionnaire can be used as an effective alternative to the OSDI. Keywords: dry eye disease, dry eye syndrome, Cornea, aqueous deficiency, refractive surgery Introduction Many patient reported outcomes (PRO) questionnaires are currently available, including ocular surface disease index (OSDI; Allergan, Irvine, CA, USA) and standard patient evaluation of eye dryness (SPEED; Tear-Science, Morrisville, NC, USA). 1 OSDI is a validated questionnaire that is frequently used in clinical trials 2 as it provides a quick assessment of dry eye disease (DED) and its impact on patient’s quality of life (QoL). 3 SPEED, a recently introduced questionnaire for DED assessment is also now being widely used by eye care practitioners across the globe. 4 , 5 A study conducted among university students in Ghana compared OSDI and SPEED in a non-clinical population, and established that both were equally good in distinguishing between symptomatic and asymptomatic patients. 6 No such study has taken in Pakistan. The prevalence of DED in Pakistan is calculated to be as high as 43.6% to 64.4%, 7 and therefore, having access to a greater number of tools can help in diagnosing this varied and large population. Thus, with this study we aim to compare the performance of OSDI and SPEED questionnaires and establish the reliability of SPEED by collecting data from a large, non-clinical population in Pakistan. Materials and Methods This cross-sectional study was conducted in Karachi after taking approval from Ethics Committee of the Hashmanis Hospital in agreement with the Declaration of Helsinki. Informed written consent was taken from all the study participants. Both questionnaires were administered simultaneously via a convenience sampling technique within a six-month period. Only those participants who were above 18 years of age, fluent in the English language and could understand the questionnaire being administered were included. We excluded participants with a prior history of intraocular surgery, meibomian gland dysfunction, ocular surface disease, an active infection, on topical medications, pregnant or breastfeeding. The study was explained clearly to every participant prior to administration. Any incomplete forms were discarded. The team of interviewers consisted of medical students who were given formal training. OSDI consisted of 12 questions to assess the symptoms experienced by the patients in the last week. It was divided into 3 sections: the frequency of the experienced symptoms, their impact on vision-related QoL, and the presence of any environmental triggers. 8 For every question, the participants had to choose amongst 5 options. Each was graded on a scale ranging from 0 to 4: None of the time (0), some of the time (1), half of the time (2), most of the time (3), and all of the time (4). The final score was calculated on a scale of 0 to 100, with higher scores representing greater disability. 4 A score between 0 and 12 is considered normal, while a score between 13 and 22 represents a mild disease, between 23 and 32 is moderate DED, and any number between 33 and 100 is indicative of severe DED. SPEED has four sections. 4 The first three assess the presence, frequency, and severity of the following symptoms: (i) Dryness, Grittiness or Scratchiness, (ii) Soreness or Irritation, (iii) Burning or Watering, (iv) Eye fatigue, and the fourth reports the use of eye drops for lubrication. Additionally, the questionnaire helps record the changes in symptoms occurring as follows: (i) At this visit, (ii) Within past 72 hours, (iii) Within past 3 months. Furthermore, the question reporting the frequency of symptoms is graded on a 4-point scale: Never (0), Sometimes (1), Often (2), or Constant (3), whereas the question investigating the severity of the experienced symptoms is divided into a 5-point scale: No problems (0), Tolerable (1), Uncomfortable (2), Bothersome (3), or Intolerable (4). Thus, by adding scores of the severity and frequency questions of SPEED questionnaire, we obtain a final SPEED score in the range of 0 to 28. Statistical Analysis All statistical analyses were performed using the SPSS V.23.0 (SPSS, Chicago, IL) statistical package. A Pearson Correlation Coefficient was used. Cronbach’s alpha was used as a measure of internal consistency to evaluate the reliability of OSDI and SPEED questionnaires, as well as their subsections. The receiver operating characteristic (ROC) curve was plotted to obtain a cutoff score for the SPEED questionnaire using OSDI, to help distinguish between symptomatic and asymptomatic subjects of the sample. This cutoff score was then further confirmed by finding an agreement between the OSDI and SPEED questionnaires using Cohen’s Kappa. Results Out of the 611 questionnaires returned, 11 were incompletely filled, hence excluded from the analysis. The questionnaires of 600 participants were thus analyzed. The average age of the participants was 31.0 ± 10.1 years. The mean OSDI and SPEED scores of the participants were 22.4 ± 19.6 and 6.02 ± 4.6, respectively. We analyzed data from 200 males and 400 females. The scores obtained by the OSDI questionnaire were used to classify all the participants into four categories. The mean SPEED scores for participants in each category were then calculated and recorded in Table 1 . Table 1 Mean Speed Score by OSDI Categorization The reliability of OSDI and SPEED questionnaires were measured using the Cronbach’s alpha, as seen in Tables 2 and 3 , respectively. The final score of the OSDI questionnaire scored relatively better, however the individual subsections of both questionnaires had similar performance. Table 2 Cronbach’s Alpha of OSDI Questionnaire and Its Sub-Sections Table 3 Cronbach’s Alpha of SPEED Questionnaire and Its Sub-Sections A scatter plot was constructed to observe the correlation between the two questionnaires. Coefficient of Correlation was calculated to be R = 0.511 0; P < 0.001, showing a moderate correlation between the total scores of both the questionnaires. This is shown in Figure 1 . Figure 1 Scatter plot of OSDI against SPEED scores. Abbreviations: SPEED, standard patient evaluation of eye dryness; OSDI, ocular surface disease index. A receiver operating characteristic (ROC) curve for the SPEED questionnaire was also plotted, and the area under the curve (AUC) was estimated to be 0.791, as shown in Figure 2 . The cut-off score for SPEED questionnaire with the maximum sum of sensitivity and specificity was found to be 4.00. This can be seen in Table 4 . Table 4 Cutoff Values for SPEED Figure 2 Area under the curve for SPEED. Abbreviation: OSDI, ocular surface disease index. The inter-rater reliability of the SPEED questionnaire at a cut-off value of 4.00 was found using Cohen’s Kappa highlighting moderate agreement between both SPEED and OSDI questionnaires for the diagnosis of DED. This can be seen in Table 5 . Table 5 Cohen’s Kappa with Various SPEED Cutoff Values Discussion We performed a cross-sectional analysis using the OSDI and SPEED questionnaires to understand if, like OSDI, SPEED can also be used to assess dry eye symptoms. Other studies have used various methods to determine the validity of SPEED, including a psychometric analysis. 4 , 6 , 9 Additionally, the questionnaire has been translated to other languages. 10 DED is a multifactorial disease with poor correlation between signs, symptoms, and clinical tests. 11–13 Despite this, patient reported outcomes (PRO) questionnaires are widely in use. These PRO questionnaires have helped remarkably in the diagnosis of DED, as well as in grading the severity and frequency of its symptoms. 14 These symptoms heavily impact the patients’ QoL, 15 , 16 and recognizing these symptoms aids in providing holistic care to the patient. OSDI is a clinically validated and widely used PRO questionnaire that has a multitude of advantages. It has been used to monitor treatment response for DED, 17 and to rule in possible clinical signs. 18 Moreover, it has also been used to validate newly introduced diagnostic tests that could potentially help in the assessment of the disease. 19 Similarly, in this study, OSDI has been used to test the reliability of SPEED questionnaire; SPEED performs comparably in terms of the internal consistency. OSDI showed a slightly better internal consistency which is explained by the fact that any questionnaire with a greater number of items will have an exaggerated Cronbach’s Alpha, regardless of its true internal consistency. 20 Furthermore, a mean SPEED value was calculated for every OSDI category. It was observed that the SPEED scores increased with the increasing degree of disease severity. This association could suggest that SPEED could also be used to assess disease severity, like the OSDI. Furthermore, the inter-rater reliability was calculated using Cohen’s Kappa which showed moderate agreement. This study shows that the SPEED questionnaire is not only comparable to OSDI in several aspects but is also reliable in distinguishing between symptomatic and asymptomatic participants. Therefore, the SPEED questionnaire can also be used as an effective tool for dry eye symptom assessment in current ophthalmic practice. However, this study does not distinguish participants based on their usage of contact lens, or any other predisposing eye diseases, and hence we cannot conclude for certain how SPEED will perform in this demographic. Furthermore, only those individuals that could speak English were included and therefore a large subset of people was missed. Acknowledgments

  • When was Visual Sciences founded?

    Visual Sciences was founded in 2000.

  • Where is Visual Sciences's headquarters?

    Visual Sciences's headquarters is located at 13450 Sunrise Valley Drive, Herndon.

  • What is Visual Sciences's latest funding round?

    Visual Sciences's latest funding round is Acquired.

  • Who are the investors of Visual Sciences?

    Investors of Visual Sciences include Webside Story, In-Q-Tel and NextPoint Partners.

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