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Founded Year

2009

About University of Strasbourg

The University of Strasbourg is an educational and research institution in the higher education sector. It offers a wide range of courses and degrees, including initial training, professional training, distance learning, continuing education, and validation of prior learning, and conducts research across various disciplines such as life sciences, health, chemistry, and physics. The university primarily serves the academic community and contributes to innovation and technology transfer in various sectors including life sciences, health, chemistry, materials physics, biomedical engineering, and the environment. It was founded in 2009 and is based in Strasbourg, France.

Headquarters Location

4 Rue Blaise Pascal

Strasbourg, 67081,

France

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University of Strasbourg Patents

University of Strasbourg has filed 2 patents.

The 3 most popular patent topics include:

  • colloidal chemistry
  • condiments
  • fluid dynamics
patents chart

Application Date

Grant Date

Title

Related Topics

Status

12/22/2010

11/17/2020

Colloidal chemistry, Fluid dynamics, Microfluidics, Biotechnology, Chemical mixtures

Grant

Application Date

12/22/2010

Grant Date

11/17/2020

Title

Related Topics

Colloidal chemistry, Fluid dynamics, Microfluidics, Biotechnology, Chemical mixtures

Status

Grant

Latest University of Strasbourg News

Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers

Dec 13, 2023

Abstract The appeal of catalytic click chemistry is largely due to the copper-catalysed azide–alkyne cycloaddition (CuAAC) process, which is orthogonal to the more recently introduced sulfur–fluoride exchange (SuFEx). However, the triazole rings generated by CuAAC are not readily modifiable, and SuFEx connectors cannot be selectively functionalized, attributes that would be attractive in a click process. Here we introduce bisphosphine–copper-catalysed phenoxydiazaborinine formation (CuPDF), a link-and-in situ modify strategy for merging a nitrile, an allene, a diborane and a hydrazine. We also present copper- and palladium-catalysed quinoline formation (Cu/PdQNF), which is applicable in aqueous media, involving an aniline as the modifier. CuPDF and Cu/PdQNF are easy to perform and deliver robust, alterable and tunable fluorescent hubs. CuPDF and Cu/PdQNF are orthogonal to SuFEx and CuAAC, despite the latter and CuPDF also being catalysed by an organocopper species. These advantages were applied to protecting group-free syntheses of sequence-defined branched oligomers, a chemoselectively amendable polymer, three drug conjugates and a two-drug conjugate. Access options Get Nature+, our best-value online-access subscription $29.99 / 30 days $259.00 per year Prices vary by article type from$1.95 Additional access options: Fig. 2: A link-and-in situ modify click process (CuPDF) that is copper-catalysed yet orthogonal to CuAAC. Fig. 3: Efficient synthesis of uniform, sequence-defined branched oligomers by combining CuPDF, CuAAC and SuFEx. Fig. 4: Efficient synthesis of uniform, sequence-defined branched oligomers by combining CuPDF, CuAAC and SuFEx. Fig. 5: Protecting group-free synthesis of a polymer. Fig. 6: Efficient bioconjugation/fluorescent marking. Data availability All data in support of the findings of this study are available within the Article and its Supplementary Information. References Kolb, H. C., Finn, M. G. & Sharpless, K. B. Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40, 2004–2021 (2001). Chatterjee, A., Xiao, H., Bollong, M., Ai, H.-W. & Schultz, P. G. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells. Proc. Natl Acad. Sci. USA 110, 11803–11808 (2013). Jang, H., Zhugralin, A. R., Lee, Y. & Hoveyda, A. H. Highly selective methods for synthesis of internal (α-) vinylboronates through efficient NHC-Cu-catalyzed hydroboration of terminal alkynes. Utility in chemical synthesis and mechanistic basis for selectivity. J. Am. Chem. Soc. 133, 7859–7871 (2011). Leophairatana, P., Samanta, S., De Silva, C. C. & Koberstein, J. T. Preventing alkyne-alkyne (that is, Glaser) coupling associated with the ATRP synthesis of alkyne-functional polymers/macromonomers and for alkynes under click (that is, CuAAC) reaction conditions. J. Am. Chem. Soc. 139, 3756–3766 (2017). Al-Huniti, M. H. et al. Development and utilization of a palladium-catalyzed dehydration of primary amides to form nitriles. Org. Lett. 20, 6046–6050 (2018). Acknowledgements Funding was provided by the ANR (project PRACTACAL), CNRS and the Jean-Marie Lehn Research Foundation at the University of Strasbourg. The early stages of this work were supported by the National Institutes of Health (GM-130395). K.E.L. was supported by a Complex Systems Chemistry (CSC) graduate fellowship funded by the French National Research Agency (CSC-IGS ANR-17-EURE-0016). We thank S.-Y. Liu, J. Niu and A. Chatterjee for helpful discussions. Author information Supramolecular Science and Engineering Institute, University of Strasbourg, Strasbourg, France Paulo H. S. Paioti, Katherine E. Lounsbury, Filippo Romiti, Michele Formica, Valentin Bauer, Claudio Zandonella & Amir H. Hoveyda Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA, USA Michele Formica, Meagan E. Hackey, Juan del Pozo & Amir H. Hoveyda Authors Katherine E. Lounsbury Filippo Romiti Michele Formica Valentin Bauer Claudio Zandonella Meagan E. Hackey Juan del Pozo Amir H. Hoveyda Contributions P.H.S.P., J.d.P., F.R. and A.H.H. conceived the concept. P.H.S.P., M.F. and C.Z. designed and performed the studies regarding the synthesis of sequence-defined oligomers and polymers, and K.E.L., F.R. and V.B. planned and carried out the bioconjugation studies. J.d.P. and M.E.H. investigated the mechanistic aspects of the CuPDF process. The investigations were directed by A.H.H., who composed the manuscript with revisions provided by the other authors. Corresponding author Peer review Peer review information Nature Chemistry thanks Shengtao Deng, Andre Isaacs, Christopher Smedley and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Additional information Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Extended data As an example, subjection of two-pronged monomers iii and iv on the one hand, and v and vi on the other, to the envisioned link-and-in situ modify conditions would deliver complementary dimers VII and IX (via VI and VIII, respectively). While VII would contain a fluorosulfate and a terminal alkyne, IX would be equipped with an azide (for CuAAC, in red) and a silyl ether (for SuFEx, in brown). Simultaneous subjection of an equal mixture of VII and IX to copper and base catalysts needed for CuAAC and SuFEx, respectively, would afford sequence-defined polymer X with amendable and differentiable linkers, depending on the amino alcohols involved in the modify steps (namely, G1 and G2). Hence, after just four chemical steps, performed in three vessels, and without the need for protection/deprotection or any other type of functional group adjustments, four monomers iii-vi could be transformed to polymer X. CuAAC, Cu-catalysed azide–alkyne cycloaddition; SuFEx, sulfur-fluoride exchange; M, monomer. a, CuAAC (in red) with phos–CuB(pin) is considerably less effective than the more established protocols (for example, condition A, Fig. 2c ). b, Experimental evidence indicating that addition of phos–CuB(pin) to an allene is faster than an alkyne. c, With dppf as the ligand, the desired three-component process affording 6 is less efficient than when phos is used (compare to data in Fig. 2b ). d, Additionally, with dppf as the ligand, chemoselectivity is lower than when phos is used: addition of the corresponding Cu–B(pin) complex to alkyne 2 is more competitive. Ts, p-toluenesulfonate; pin, pinacolato; dppf, 1,1’-bis(diphenylphosphino)ferrocene; CuAAC, copper(I)-catalysed alkyne-azide cycloaddition; Bz, benzoate.

University of Strasbourg Frequently Asked Questions (FAQ)

  • When was University of Strasbourg founded?

    University of Strasbourg was founded in 2009.

  • Where is University of Strasbourg's headquarters?

    University of Strasbourg's headquarters is located at 4 Rue Blaise Pascal, Strasbourg.

  • Who are University of Strasbourg's competitors?

    Competitors of University of Strasbourg include Universidad Europea de Madrid and 3 more.

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