Founded Year

2014

Stage

Loan | Alive

Total Raised

$13.87M

Last Raised

$250K | 2 yrs ago

About Aria Pharmaceuticals

Aria Pharmaceuticals is a preclinical-stage pharmaceutical company that discovers and develops novel small molecule therapies for complex and hard-to-treat diseases

Aria Pharmaceuticals Headquarter Location

265 Cambridge Ave #60099

Palo Alto, California, 94306,

United States

650-382-2605

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Research containing Aria Pharmaceuticals

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CB Insights Intelligence Analysts have mentioned Aria Pharmaceuticals in 1 CB Insights research brief, most recently on Mar 16, 2022.

Expert Collections containing Aria Pharmaceuticals

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Aria Pharmaceuticals is included in 3 Expert Collections, including Artificial Intelligence.

A

Artificial Intelligence

9,093 items

This collection includes startups selling AI SaaS, using AI algorithms to develop their core products, and those developing hardware to support AI workloads.

D

Digital Health

13,075 items

Technologies, platforms, and systems that engage consumers for lifestyle, wellness, or health-related purposes; capture, store, or transmit health data; and/or support life science and clinical operations. (DiME, DTA, HealthXL, & NODE.Health)

B

Biopharma Tech

838 items

Latest Aria Pharmaceuticals News

Why Aria Pharmaceuticals is upbeat about two novel IPF treatment candidates

Sep 23, 2021

Drug Discovery and Development September 23, 2021 Small molecule drug developer Aria Pharmaceuticals (Palo Alto, Calif.) recently revealed that two investigational treatments for idiopathic pulmonary fibrosis (IPF), TXR-1002 and TXR-1007, demonstrated promising results in preclinical research. There are currently only two FDA-approved treatments for IPF on the market — nintedanib (Ofev) from Boehringer Ingelheim and pirfenidone (Esbriet) from Roche . While those introductions marked a turning point in treating IPF, managing the disease remains challenging for many patients. Both TXR-1002 and TXR-1007 rely on a mechanism of action than that of nintedanib or pirfenidone. And Aria reports that preclinical testing indicated that the drugs were well tolerated. “Certainly, you can’t tell if a rat is suffering from nausea or something like that, but at a gross level, the animals did well through the course of the study,” said Mark Eller, senior vice president, R&D at Aria Pharmaceuticals. “We’re optimistic based on the mechanism and the data that we’ve collected so far that we’re onto something.” Mark Eller “It’s hard to say that any given animal model is really good for something that’s idiopathic,” Eller acknowledged. But the animal model Aria used is “sort of the gold standard” and “was used for both nintedanib and pirfenidone.” The model considers both inflammation and fibrosis. TXR-1002 and TXR-1007 fared well in both respects. The company plans to conduct further testing on the two drug candidates. The preclinical research indicates that the drug candidates have significant efficacy in reducing lung collagen and the infiltration of neutrophils and lymphocytes in the lung, which are markers for inflammation. “Usually, it’s the inflammation that comes first, and then the fibrosis follows that,” Eller said. Thus, Aria’s model was focused on quantifying lung damage associated with fibrosis. In that respect, the company had “statistically significant results — in fact, numerically superior to nintedanib for lung collagen, which is a fibrosis marker.” Eller said that the reductions in neutrophils and lymphocytes were not statistically significant. “That’s probably due to the timing,” he said. Because inflammation precedes fibrosis, the company could potentially measure both variables at various times to get a clearer picture of how the investigational drugs impact both factors. The prevalence of IPF appears to have risen in recent decades, according to a 2018 paper published in  Medical Sciences . In addition, the ongoing pandemic and factors such as rampant wildfires could heighten the need for new IPF treatments. Researchers have also identified that certain occupations such as firefighting may elevate the risk for interstitial lung diseases, including IPF. “It is an important area for continued research on the part of the pharmaceutical industry,” Eller concluded.

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  • When was Aria Pharmaceuticals founded?

    Aria Pharmaceuticals was founded in 2014.

  • Where is Aria Pharmaceuticals's headquarters?

    Aria Pharmaceuticals's headquarters is located at 265 Cambridge Ave, Palo Alto.

  • What is Aria Pharmaceuticals's latest funding round?

    Aria Pharmaceuticals's latest funding round is Loan.

  • How much did Aria Pharmaceuticals raise?

    Aria Pharmaceuticals raised a total of $13.87M.

  • Who are the investors of Aria Pharmaceuticals?

    Investors of Aria Pharmaceuticals include Paycheck Protection Program, National Cancer Institute, Andreessen Horowitz, Softbank Ventures Asia, OS Fund and 4 more.

  • Who are Aria Pharmaceuticals's competitors?

    Competitors of Aria Pharmaceuticals include Insilico Medicine, BenevolentAI, Exscientia, Standigm, Recursion and 9 more.

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