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HEALTHCARE | Drug Development
tizonatx.com

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Founded Year

2015

Stage

Corporate Minority | Alive

Total Raised

$343M

Valuation

$0000 

Last Raised

$300M | 2 yrs ago

About Tizona Therapeutics

Tizona Therapeutics is a privately held immunology company harnessing the power of the immune system to develop treatments for cancer and autoimmune disorders. A healthy immune system integrates information from pro-inflammatory and anti-inflammatory cells that regulate the immune system's function. In cancer, tumor cells evade recognition by controlling cells that suppress the proper function of the immune system. In autoimmune disease, the immune system attacks "self" tissues in the body due to insufficient regulation. Tizona's therapies are designed to regulate these suppressive cells, thereby either activating the body's ability to fight cancer or preventing the immune system from attacking healthy tissues in autoimmune diseases.

Tizona Therapeutics Headquarter Location

4000 Shoreline Court Suite 200

South San Francisco, California, 94080,

United States

650-383-0800

Latest Tizona Therapeutics News

Laronde Expands Board of Directors with Leading Pharmaceutical Executives

Nov 1, 2021

Company appoints Sheri McCoy, former Johnson & Johnson vice chairman, who brings decades of company-building expertise, and Pablo Cagnoni, M.D., biotech CEO who led the development and commercialization of multiple life-changing treatments November 01, 2021 08:00 AM Eastern Daylight Time CAMBRIDGE, Mass.--( BUSINESS WIRE )--Laronde, the company pioneering Endless RNA™ (eRNA) – a novel, engineered form of RNA that can be programmed to express therapeutic proteins inside the body – today announced that two senior industry leaders, Sheri McCoy, and Pablo Cagnoni, M.D. have been appointed to the company’s board of directors. Together, they bring deep experience driving research, development, and commercialization of life-saving medicines from some of the most prestigious global pharmaceutical companies. “At Laronde, we are advancing a powerful new therapeutic modality with Endless RNA. To realize the full potential of our technology platform, we must build a world-class organization to deliver future essential medicines to patients around the globe,” said Diego Miralles, M.D., Chief Executive Officer of Laronde. “On the heels of our successful Series B financing, we are excited to welcome Pablo and Sheri to our board of directors. The caliber of experience they bring is invaluable as we scale the next phase of strategic growth and build a company with high impact in the world.” Ms. McCoy spent 30 years at Johnson & Johnson (J&J), ultimately serving as Vice Chairman of the executive committee responsible for the pharmaceutical and consumer businesses, comprising more than 60 percent of the company’s revenues. She joined J&J as a research and development scientist and later managed businesses in every major product area, including consumer, pharmaceuticals, and medical devices. Following her tenure at J&J, Ms. McCoy served as Chief Executive Officer of Avon, a global leader in personal care. Currently, she serves on the boards of several industry-leading companies, including AstraZeneca and Stryker, and is a healthcare industry advisor for EQT Partners. Ms. McCoy holds a bachelor’s degree in textile chemistry from the University of Massachusetts Dartmouth, a master’s degree in chemical engineering from Princeton University, and a master’s degree in business administration from Rutgers University. She holds four U.S. patents and has been on Fortune magazine's "50 Most Powerful Women in Business." In August 2012, Forbes magazine recognized her as the 39th most powerful woman in the world. “Laronde has assembled a group of talented trailblazers who are advancing a truly unique therapeutic platform and building a world-class organization to support their bold ambitions,” said Ms. McCoy. “We’ve all seen the power of RNA-based therapeutics. The potential of Endless RNA is far-reaching, with applications that may replace or augment many drug modalities currently in use. It is an honor to work alongside their team as they build an industry-leading biotech company.” Dr. Cagnoni continued by saying, “The team at Laronde is tackling the development of eRNA in a truly multi-faceted and differentiated way that is not limited to the confines of traditional drug development. Laronde’s technology has the potential to usher in a new era of RNA-based therapeutics that are highly programmable, capable of producing persistent expression of therapeutic proteins inside the body, allow repeat redosing, and multiple routes of administration. I’m excited to join the board at this pivotal time to explore new and innovative ways to treat complex diseases.” Over the course of his career, Dr. Cagnoni played a key role in the development and commercialization of more than 20 life-changing treatments, including Afinitor®, Kyprolis®, and Tarceva®. The oncologist and pharmaceutical executive is currently President and Chief Executive officer of Rubius Therapeutics. Previously, he served as President and Chief Executive Officer of Tizona Therapeutics, a privately held biotech company focused on developing next-generation immunotherapies for the treatment of cancer. In 2020, Gilead Sciences secured an exclusive option to acquire Tizona for up to $1.5 billion. Previously, Dr. Cagnoni was President of Onyx Pharmaceuticals, an Amgen subsidiary. Earlier in his career, he held senior leadership roles at Novartis Oncology, Allos Therapeutics (acquired by Spectrum Pharmaceuticals), and OSI Pharmaceuticals (acquired by Astellas). Dr. Cagnoni earned his medical degree from the University of Buenos Aires School of Medicine and completed fellowships in hematology and oncology at Mount Sinai Medical Center and in stem cell transplantation at the University of Colorado Health Sciences Center. He was also an Assistant Professor of medicine at the University of Colorado’s bone marrow transplant program. About Endless RNA™ Ribonucleic Acids, or RNAs, play a significant role in biology. Among their functions, they provide the "code" that instructs cells to produce or regulate proteins, the building blocks of life and important regulators of disease processes. Because RNAs provide coded instructions to cells, they can be programmed to produce specific effects. This approach has been validated by the successful development of several important RNA-based medicines, but RNA's potential as a drug development modality has just begun. Endless RNA™, or eRNA, was invented at Flagship Labs and is a new class of synthetic, closed-loop RNA. Because eRNA has no free ends, it is not recognized by the immune system and is very stable, enabling a long duration of protein expression. In addition, eRNA can serve protein-coding and non-protein-coding functions, and its protein translation capabilities are completely modular — switching an eRNA "protein sequence cassette" enables the expression of a different protein or multiple proteins that can be tuned as needed on an application-by-application basis. About Laronde Laronde is pioneering a platform that offers a completely novel way of modulating human biology. Endless RNA™ (eRNA), invented at Flagship Labs, is a uniquely engineered RNA that can be programmed to express diverse proteins inside the body. It is persistent, non-immunogenic, allows for repeat dosing, and offers flexibility in formulation and delivery. Laronde was founded in 2017 by Flagship Labs, the innovation foundry of Flagship Pioneering. The company is rapidly scaling to support the parallel development of multiple programs across many disease areas. To learn more, please visit the company's website at https://www.laronde.bio/ or Twitter and LinkedIn . Contacts

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Expert Collections containing Tizona Therapeutics

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Tizona Therapeutics is included in 3 Expert Collections, including Cancer.

C

Cancer

4,784 items

Pharmaceutical and biotechnology companies with cancer therapy drug candidates.

B

Biopharma Tech

15,533 items

Companies involved in the research, development, and commercialization of chemically- or biologically-derived therapeutic & theranostic drugs. Excludes vitamins/supplements, CROs/clinical trial services.

R

Regenerative Medicine

1,818 items

Regenerative medicine refers to the process of activating, replacing, engineering or regenerating human genetic material, cells, tissues or organs to restore normal function. It also includes bioengineered tissues used for in vitro testing (e.g. organ-on-a-chip, organoids).

Tizona Therapeutics Patents

Tizona Therapeutics has filed 4 patents.

The 3 most popular patent topics include:

  • Clusters of differentiation
  • Human proteins
  • Immune system
patents chart

Application Date

Grant Date

Title

Related Topics

Status

9/26/2019

12/28/2021

Clusters of differentiation, Immunology, Immune system, Transcription factors, Cytokines

Grant

Application Date

9/26/2019

Grant Date

12/28/2021

Title

Related Topics

Clusters of differentiation, Immunology, Immune system, Transcription factors, Cytokines

Status

Grant

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