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Synergetic

synergetic.net

Stage

Private Equity | Alive

About Synergetic

Synergetic sells cleaning products that are eco-friendly.

Headquarters Location

58 Taicang Road Floor 2

Shanghai, Shanghai, 200021,

China

+86 21 6103 6845

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Latest Synergetic News

Lactosylated IR820/DOX Co-Assembled Nanodrug for Synergetic Antitumour Therapy

Jun 21, 2020

Email yuxialuan@sdu.edu.cn Introduction: Synergistic treatment integrating photothermal therapy (PTT) and chemotherapy is a promising strategy for hepatocellular carcinoma (HCC). However, the most commonly used photothermal agent, IR820, and chemotherapeutic drug, doxorubicin hydrochloride (DOX), are both hydrophilic molecules that suffer from the drawbacks of a short circulation time, rapid elimination and off-target effects. Methods and Results: Herein, a novel nanodrug that combined HCC-targeted IR820 and DOX was developed based on excipient-free co-assembly. First, lactosylated IR820 (LA-IR820) was designed to target HCC. Then, the LA-IR820/DOX nanodrug (LA-IR820/DOX ND) was purely self-assembled without excipient assistance. The physicochemical properties and the chemo-photothermal antitumour activity of the excipient-free LA-IR820/DOX ND were evaluated. More importantly, the obtained LA-IR820/DOX ND exhibited 100% drug loading, remarkable HCC targeting and excellent antitumour efficacy. Conclusion: This excipient-free LA-IR820/DOX ND may be a promising candidate for the synchronous delivery and synergistic targeting of IR820 and DOX as a combined chemo-photothermal therapy. Keywords: excipient-free, hepatoma cell targeting, self-assembly nanodrug, photothermal therapy, chemotherapy This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License . By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms .

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Synergetic Frequently Asked Questions (FAQ)

  • Where is Synergetic's headquarters?

    Synergetic's headquarters is located at 58 Taicang Road, Shanghai.

  • What is Synergetic's latest funding round?

    Synergetic's latest funding round is Private Equity.

  • Who are the investors of Synergetic?

    Investors of Synergetic include Baring Vostok Capital Partners.

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