StageAcquired | Acquired
The Spirogen group was founded in 2001 as a spin-out from several institutions including University College, London and partly funded by Cancer Research UK.The group has developed a novel class of highly potent cytotoxic warheads based on its proprietary pyrrolobenzodiazepines (PBDs), DNA minor groove binding agents, which bind and cross-link specific sites of DNA of the cancer cell. This blocks the cancer cells' division without distorting its DNA helix, thus potentially avoiding the common phenomenon of emergent drug resistance. Spirogen has been developing its PBD technology for more than ten years, including a standalone PBD agent already in a clinical study in acute myeloid leukemia (AML). The company's business model has been to partner its technology with pharma and biotech for use in the development of novel drugs.
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Expert Collections containing SpiroGen
Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.
SpiroGen is included in 1 Expert Collection, including Cancer.
Pharmaceutical and biotechnology companies with cancer therapy drug candidates.
SpiroGen has filed 7 patents.
Stem cells, Transcription factors, Biotechnology, Cell biology, Induced stem cells
Stem cells, Transcription factors, Biotechnology, Cell biology, Induced stem cells
Latest SpiroGen News
Jan 17, 2018
Learn more about: – New and novel payloads, e.g. – Using minor-groove binding DNA-interactive molecules as ADC payloads. – The practicalities of the use of Highly Potent Active Pharmaceutical Ingredients within ADC development. – Using fragment drug conjugates to develop a more tailored therapy for solid tumours. – Design principles for maximising the drug delivery efficiency and therapeutic index. Day 1: Compare new generation HER-2 ADCs with Kadcyla™, examine technological advancements on PK-PD, highly potent ingredients, adc payloads and explore drug designs for ADCs; whilst Day 2 takes a look at fragmented drug conjugates and therapeutic windows, warheads and site selectivity, immune-oncological combination therapies, and design principles for maximising drug delivery. Day 1 Keynote Address: PBDs – Update on an Efficient & Effective Payload Class: Hear from Spirogen as they discuss one of the main aspects of ADCs; payloads, advanced methods of characterisation will be extremely important as this class of biologics (ADC payloads) is translated to industrial-scale production. Whether or not PBDs make better payloads than others, the clinical progress and current uses of PBDs with case study examples and new PBD payloads in developments; consequences on mode of action, efficacy and tolerability. PBDs are a class of DNA-crosslinking agents, they are significantly more potent than systemic chemotherapeutic drugs. Benefit from Arnaud Tiberghien, Scientist II, Chemistry, Spirogen who will explain the challenges and the significance of PBD payloads. Presented to you by: Arnaud Tiberghien, Scientist II, Chemistry, Spirogen Day 2 Keynote Address: Guided Warhead Loaded Missiles of ADCs in Fight Against Deadly Cancers: Challenges and Opportunities: Current antibody-drug conjugates in development have immense promise, but they are limited by the fact that they are structurally heterogeneous populations in which the position and number of conjugated linkers and warheads vary significantly. MedImmune will explore the target, linker, warhead selection: Do’s and Don’ts; five rights of creation of the best optimized fit-for-purpose ADCs; internalisation of ADCs – how to improve internalisation, lysosomal delivery and intracellular target hit and increasing the effectiveness of the ADCs by effective tumour targeting minimising the off-target toxicity of ADCs. Presented to you by: Rakesh Dixit, Vice President, R&D, Global Head, Biologics Safety Assessment, MedImmune Inc Further information is available at: www.adcsummit.com/phpr SMi presents the 6th Annual Conference: ADC Summit Location: Copthorne Tara Hotel, London UK Website: www.adcsummit.com/phpr
SpiroGen Frequently Asked Questions (FAQ)
Where is SpiroGen's headquarters?
SpiroGen's headquarters is located at The QMB Innovation Centre, London.
What is SpiroGen's latest funding round?
SpiroGen's latest funding round is Acquired.
How much did SpiroGen raise?
SpiroGen raised a total of $16.45M.
Who are the investors of SpiroGen?
Investors of SpiroGen include MedImmune, Auven Therapeutics, Cambridge Research & Innovation, Research Corporation Technologies and UCL Business.
Who are SpiroGen's competitors?
Competitors of SpiroGen include Kiadis Pharma, Annovis Bio, Esperance Pharmaceuticals, OncoMed Pharmaceuticals, Activate Immunotherapy, InClinica, Syndax Pharmaceuticals, Ikaria, LIDDS, RetroScreen Virology and 32 more.
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