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Spine Wave

Founded Year



Loan | Alive

Total Raised


Last Raised

$3.5M | 3 yrs ago

About Spine Wave

Spine Wave is a medical device company. It develops a procedure for treating back pain and other spinal conditions by restoring the function of the spinal disc. It uses an injectable protein-based formulation for the repair of spinal discs damaged either by injury or aging. It was founded in 2001 and is based in Shelton, Connecticut.

Headquarters Location

3 Enterprise Drive Suite 210

Shelton, Connecticut, 06484,

United States


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Expert Collections containing Spine Wave

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Spine Wave is included in 3 Expert Collections, including Medical Devices.


Medical Devices

11,721 items

Companies developing medical devices (per the IMDRF's definition of "medical device"). Includes software, lab-developed tests (LDTs), and combination products. *Columns updated as regularly as possible.


Digital Health

10,347 items

The digital health collection includes vendors developing software, platforms, sensor & robotic hardware, health data infrastructure, and tech-enabled services in healthcare. The list excludes pureplay pharma/biopharma, sequencing instruments, gene editing, and assistive tech.


Health IT

7,901 items

Spine Wave Patents

Spine Wave has filed 209 patents.

The 3 most popular patent topics include:

  • Orthopedic surgical procedures
  • Bones of the vertebral column
  • Neurosurgery
patents chart

Application Date

Grant Date


Related Topics




Surgical instruments, Orthopedic surgical procedures, Bone fractures, Stereochemistry, Neurosurgery


Application Date


Grant Date



Related Topics

Surgical instruments, Orthopedic surgical procedures, Bone fractures, Stereochemistry, Neurosurgery



Latest Spine Wave News

Posterior facet replacement may yield decompression, stabilization for spondylolisthesis

Apr 5, 2023

Disclosures: Coric reports having stock ownership in Premia Spine; being a consultant for Premia Spine, Spine Wave, Globus Medical, Medtronic, Integrity Implants, SpineArt and NuVasive; receiving royalties from Spine Wave, Globus Medical, Medtronic, Integrity Implants, Stryker Spine and Surgalign; and funding to institution for this study from Premia Spine. ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Please try again later. If you continue to have this issue please contact . Back to Healio Key takeaways: Posterior facet replacement had a higher rate of clinical success for the overall composite measure vs. fusion. The minimum 15-point improvement in Oswestry Disability Index favored posterior facet replacement. Results showed use of a posterior facet replacement device may provide adequate decompression and dynamic stabilization in patients with lumbar stenosis with degenerative spondylolisthesis. Although lumbar stenosis with degenerative spondylolisthesis has historically been treated with decompression and fusion, Dom Coric, MD, said fusion stops motion at the facets, which may lead to increased stress at the levels above and below the fusion and can lead to increased risk of reoperation. However, he noted stabilization may be achieved and motion may be maintained with the use of decompression and an artificial facet. Data were derived from Coric D, et al. J Neurosurg Spine. 2022;doi:10.3171/2022.7.SPINE22536. Dom Coric “[With an artificial facet], now you have a situation where the nerves are free; the patients have done well; and you have maintained the motion, which is more of a natural phenomenon. And furthermore, you’re not placing this additional stress at the adjacent levels,” Coric, of Carolina Neurosurgery and Spine Associates and SpineFirst Atrium Health, told Healio. “So it’s a win-win situation, and that’s what the results of the study bore out: The patients that had decompression and dynamic stabilization with facet replacement did better than patients who had decompression and stabilization with the fusion.” Posterior facet replacement vs. fusion Coric and colleagues randomly assigned 249 patients with one-level symptomatic lumbar stenosis with grade I degenerative spondylolisthesis to undergo either posterior facet replacement with the Total Posterior Spine system (n=170; TOPS, Premia Spine) or transforaminal lumbar interbody fusion (n=79; TLIF). Researchers collected the Oswestry Disability Index (ODI) and VAS for back and leg pain preoperatively and at 6 weeks and at 3, 6, 12 and 24 months postoperatively. Researchers considered no reoperations, no device breakage, reduction of ODI of 15 points or more and no new or worsening neurological deficit as the primary outcome, with patients considered clinically successful if they met all four measures. Results showed 85% of patients in the TOPS group met the overall composite measure for clinical success compared with 64% of patients in the TLIF group. Researchers found a statistically significant difference in the percentage of patients reporting a minimum 15-point improvement in ODI, with 93% in the TOPS group vs. 81% in the TLIF group. However, researchers noted no statistically significant difference in the percentage of patients reporting a minimum 20-point improvement in VAS back pain and leg pain scores between the two groups. Rate of reintervention The TOPS group had a lower rate of surgical reintervention for facet replacement vs. the TLIF group (5.9% vs. 8.8%), according to results. From preoperatively to 24 months, researchers found patients in the TOPS group demonstrated maintenance of flexion/extension range of motion. “One-level TLIF is a common and well thought of operation. In other words, you would expect the success rate of that type of operation to be reasonably high. So, to show superiority to that, I think, is a positive,” Coric said. Read more about

Spine Wave Frequently Asked Questions (FAQ)

  • When was Spine Wave founded?

    Spine Wave was founded in 2001.

  • Where is Spine Wave's headquarters?

    Spine Wave's headquarters is located at 3 Enterprise Drive, Shelton.

  • What is Spine Wave's latest funding round?

    Spine Wave's latest funding round is Loan.

  • How much did Spine Wave raise?

    Spine Wave raised a total of $141.05M.

  • Who are the investors of Spine Wave?

    Investors of Spine Wave include Paycheck Protection Program, New Enterprise Associates, California Technology Ventures, Compass EMP, MB Venture Partners and 20 more.

  • Who are Spine Wave's competitors?

    Competitors of Spine Wave include Vertos Medical, Flowonix Medical, Avedro, AxioMed, Gentis and 12 more.

Compare Spine Wave to Competitors

Spinal Restoration

Spinal Restoration restores patients' lives by delivering new therapies that address unmet needs in spine health management. These therapies are minimally invasive, early interventions with clinically proven results. The company is working with a diverse, highly regarded group of clinical and scientific advisors to develop and gain regulatory approval of the Biostat System, a proprietary resorbable biologic and delivery system for the treatment of chronic disc pain, based on solid scientific and clinical evidence.

Theken Disc

Theken Disc, LLC founded in 2003 designs, develops and manufactures spinal arthroplasty products, such as the eDisc, a microelectronic artificial spinal disc replacement.

Disc Dynamics

Disc Dynamics has developed the DASCORTM Disc Arthroplasty System, an innovative, minimally invasive nucleus replacement treatment for patients suffering from chronic low back pain caused by Degenerative Disc Disease (DDD).

Applied Spine Technologies

Applied Spine Technologies is a spine company focused on developing implantable dynamic stabilization systems for the treatment of chronic back pain.


Gentis is a developer of minimally invasive, biomaterials-based products intended to treat the early-stage degeneration of the spine, which causes back pain. The company's first patented product, DiscCell, is a breakthrough injectable biomaterial that augments or replaces the diseased nucleus pulposus of the spinal disc.


Orthonicsis a company created through Georgia Tech's Venturlab program. Orthonics is developing biomaterials for orthopaedic tissue engineering applications. The company's core technology relates to biomaterials that permit in-growth and adhesion of bone and cartilage tissues. Initial applications will be spinal disc replacement and as aspinal disc annulus patch.

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