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About South Dakota State University

South Dakota State University is a university. Its academic programs provide hands-on learning with professional experiences through internships, study abroad, and the experiential learning students seek.

South Dakota State University Headquarter Location

1175 Medary Ave

Brookings, South Dakota, 57006,

United States

605-688-4121

Latest South Dakota State University News

Compounds from soybeans may improve animal health

Nov 23, 2021

The sprouting soybeans, in front, have been inoculated with a pathogen to trigger production of glyceollins, which have antimicrobial properties. Scaling up these lab experiments at the POET Bioproducts Institute may lead to soybeans that are rich in glyceollins being integrated into animal feed to help prevent disease and reduce the need for antibiotics. Credit: South Dakota State University Antimicrobial compounds that soybean plants produce when threatened by insects, diseases and even drought may help animals stay healthy, thereby reducing the need for antibiotics. "When a soybean is attacked by a pathogen, the plant produces phytochemicals called glyceollins as a defense mechanism," explained assistant professor Bishnu Karki of South Dakota State University's Department of Biology and Microbiology. Her research group has identified pathogens and lab-scale processes to trigger production of glyceollins and begun assessing soybean varieties to see which produce higher levels of the antimicrobial compounds. "Animals, such as pigs and poultry, already consume diets high in soybeans and could benefit from the phytochemical's antimicrobial properties," Karki said, pointing out scientists are studying the impact of glyceollins on human health, specifically in relation to cancer, inflammation and cardiovascular diseases. Karki's research is supported by U.S. Department of Agriculture Hatch Act funding through the South Dakota Agricultural Experiment Station. Two master's students and several undergraduates have also worked on the project. In the past, antibiotics were integrated into animal feed and water to help animals stay healthy and reach market weight efficiently. However, the FDA's Veterinary Feed Directive, which seeks to decrease the development of antibiotic-resistance microorganisms, recently limited the use of antibiotics to specific health problems. Therefore, livestock producers are in need of natural alternatives, such as glyceollin-enriched soybeans, that can provide benefits similar to those of antibiotics. Producing glyceollins Under normal conditions, glyceollins are not present in soybeans, Karki said When soybeans are threatened by environmental stressors, such as a fungal infection , the plant responds by making glyceollins to defend itself. Karki and her team worked with research chemist Mark Berhow of the functional foods group at the USDA Agricultural Research Service in Peoria, Illinois, to determine how to maximize glyceollins production in soybeans. The goal was to produce at least three milligrams of glyceollins per gram of soybeans, the amount needed for use as an antimicrobial in swine feed. The researchers found dehulled, sprouted soybeans inoculated with fungi produced higher glyceollins levels than beans in the hull or halved. The soybeans are then freeze-dried and ground to determine glyceollins levels. Results, published in the Mycological Progress journal, showed the capacity to produce 3.763 mg of glyceollins per gram of soybeans. Doctoral candidate Ahmad Alhomodi, left, and assistant professor Bishnu Karki of the Department of Biology and Microbiology examine soybeans inoculated with two different edible fungi. The pathogens stress the beans so they produce glyceollins, which have antimicrobial properties. Credit: South Dakota State University In a subsequent study, the researchers evaluated about a dozen soybean varieties, inoculating them with two varieties of edible fungus and incubating them for up to 120 hours. They found that the fungus, Aspergillus sojae, elicited better production of glyceollins with levels peaking from 96 to 120 hours incubation. In addition, Karki said, "the soybean variety makes a difference." Although a variety's susceptibility to fungal diseases did not boost production, the early maturing varieties tended to produce more glyceollins and exposure to ultraviolet light before fungal inoculation improved those results. The next step will be to test a greater number of varieties from different states to identify those with higher potential for producing glyceollins and then work with breeders to examine the genetic pathways through which this occurs. Going to the next level "We have a lab-scale process, but we need to scale it up to show its feasibility," Karki said, noting that testing to make sure the process was repeatable involved up to 100 beans. The new POET Bioproducts Institute in the Research Park at SDSU will play an integral role in scaling up this technology. The facility should be completed by summer 2023. "The use of naturally-occurring compounds to replace antibiotics could be a game-changer in the animal production industry. Through the POET Bioproducts Institute, researchers can collaborate with industry partners to bring promising bioprocessing technologies such as this to the marketplace," said Distinguished Professor Bill Gibbons, associate dean for research for the College of Agriculture, Food and Environmental Sciences and director of the South Dakota Agricultural Experiment Station. "Production of glyceollins is better when soybeans are dehulled, but we need to keep the endosperm intact for seed to germinate," she continued. "Commercial dehulling equipment can crack the soybeans, so we need to custom design a machine that can remove the hulls without disrupting the endosperm." Furthermore, understanding the metabolic pathways through which soybeans divert energy to producing glyceollins will help scientists manipulate those pathways to increase production of the antimicrobial compound. "Soybeans are one of the largest commodities in the animal and human nutrition market," Karki said. If soybeans rich in glyceollins can provide health benefits to animals, they may also have potential for improving human health . Explore further

Oct 11, 2021
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South Dakota State University Patents

South Dakota State University has filed 4 patents.

The 3 most popular patent topics include:

  • Bacterial toxins
  • Invertebrate toxins
  • Ion channel toxins
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11/23/2018

5/25/2021

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