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Oregon Health & Science University

ohsu.edu

Founded Year

1887

Stage

Grant - III | Alive

Total Raised

$8.3M

Last Raised

$2.4M | 2 yrs ago

About Oregon Health & Science University

Oregon Health & Science University is a research university based in Oregon.

Headquarters Location

3181 S.W. Sam Jackson Park Rd.

Portland, Oregon, 97239,

United States

503 494-8311

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Oregon Health & Science University Patents

Oregon Health & Science University has filed 230 patents.

The 3 most popular patent topics include:

  • Transcription factors
  • Molecular biology
  • Clusters of differentiation
patents chart

Application Date

Grant Date

Title

Related Topics

Status

9/11/2018

1/17/2023

Diseases of the eye and adnexa, Eye surgery, Glaucoma, Ophthalmology, Blindness

Grant

Application Date

9/11/2018

Grant Date

1/17/2023

Title

Related Topics

Diseases of the eye and adnexa, Eye surgery, Glaucoma, Ophthalmology, Blindness

Status

Grant

Latest Oregon Health & Science University News

Nanotechnology May Improve Gene Therapy for Blindness

Jan 13, 2023

Using nanotechnology that enabled mRNA-based COVID-19 vaccines, a new approach to gene therapy may improve how physicians treat inherited forms of blindness, according to the National Eye Institute. A collaborative team of researchers with Oregon Health & Science University and Oregon State University have developed an approach that uses lipid nanoparticles—tiny, lab-made balls of fat—to deliver strands of messenger ribonucleic acid, or mRNA, inside the eye. To treat blindness, the mRNA will be designed to create proteins that edit vision-harming gene mutations. New gene therapy method encases gene-editing molecules inside a shell of lipid nanoparticles. This scientific illustration shows the approach's lipid nanoparticle shells, which appear as fuzzy beige balls after they have been injected into the eye. Image credit: Tetiana Korzun, Oregon Health and Science University In a study published in Science Advances, the team demonstrates how its lipid nanoparticle delivery system targets photoreceptors in both mice and nonhuman primates. The system’s nanoparticles are coated with a peptide that the researchers identified as being attracted to photoreceptors. The scientists demonstrated that a peptide-covered lipid nanoparticle shell can be directed toward photoreceptor cells in the retina, tissue in the back of the eye that enables sight. As a first proof of concept, mRNA with instructions to make green fluorescent protein was placed inside nanoparticles. After injecting this nanoparticle-based gene therapy model into the eyes of mice and nonhuman primates, the research team used a variety of imaging techniques to examine the treated eyes. The animals’ retinal tissue glowed green, illustrating that the lipid nanoparticle shell reached photoreceptors and that the mRNA it delivered successfully entered the retina and created green fluorescent protein. This research marks the first time that lipid nanoparticles are known to have targeted photoreceptors in a nonhuman primate. The Ohio State news release can be found here. The Oregon State news release can be found here.

Oregon Health & Science University Frequently Asked Questions (FAQ)

  • When was Oregon Health & Science University founded?

    Oregon Health & Science University was founded in 1887.

  • Where is Oregon Health & Science University's headquarters?

    Oregon Health & Science University's headquarters is located at 3181 S.W. Sam Jackson Park Rd., Portland.

  • What is Oregon Health & Science University's latest funding round?

    Oregon Health & Science University's latest funding round is Grant - III.

  • How much did Oregon Health & Science University raise?

    Oregon Health & Science University raised a total of $8.3M.

  • Who are the investors of Oregon Health & Science University?

    Investors of Oregon Health & Science University include National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health and Bill & Melinda Gates Foundation.

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