Predict your next investment

HEALTHCARE | Medical Devices & Equipment

See what CB Insights has to offer


Seed | Alive

Total Raised


Last Raised

$250K | 13 yrs ago

About Ocusciences

OcuSciences is developing a product to use images from the eye to detect diseases such as diabetes at an earlier stage.

Ocusciences Headquarter Location

Ann Arbor, Michigan, 48103,

United States

Latest Ocusciences News

OcuSciences Announces Publication Showing Flavoprotein Fluorescence May Detect Improvement in Metabolic Function Preceding Structural Improvement in Patients with Diabetic Macular Edema Treated with AntiVEGF

Jan 2, 2019

OcuSciences, Inc., a clinical-stage biotechnology company developing retinal imagers to detect early disease by assessing retinal metabolic activity, today announced the online publication of its diabetic macular edema study . The findings suggest that FPF can detect improvement in metabolic function that more directly correlates to vision improvement than the improvement in macular thickness measured by optical coherence tomography in DME patients treated with anti-VEGF. The study, led by Dr. Richard Rosen, MD, professor of ophthalmology at New York Eye and Ear Infirmary of Mount Sinai, followed eight patients with clinically significant DME (CSDME) before and after treatment with anti-VEGF injections. Dr. Rosen and lead author Dr. Jorge Andrade Romo, MD, found that the change in flavoprotein fluorescence (FPF) before and after injection, measured by OcuSciences’ flagship device, the OcuMet Beacon, more closely correlated with the change in best corrected visual acuity (BCVA) than that of the change in central macular thickness (OCT CMT) and BCVA. This suggests that FPF can detect metabolic improvements that precede structural improvements in DME patients benefitting from anti-VEGF injections. “This was a very important study for OcuSciences and our metabolic imager. The OcuMet Beacon, which rapidly and quantitatively measures FPF, could be a more sensitive measure of retinal health and improvement in vision than other measures for DME patients such as the gold standard, OCT,” said Kurt Riegger, President and COO of OcuSciences. “This study suggests ophthalmologists and optometrists can begin to look for the earliest signs of retinal damage and improvement with therapy for their patients. If we can detect disease earlier, treat patients earlier, know whether or not a therapy is working earlier, we can improve patient outcomes.” The imaging modality for the OcuMet Beacon is based on research that was conducted at the University of Michigan Kellogg Eye Center by Victor Elner, MD, PhD, an ophthalmologist and pathologist, and Howard Petty, PhD, a biophysicist and immunologist. The OcuMet Beacon uses a very specific wavelength of light that excites flavoproteins in the mitochondria that are not “working” efficiently. The dysfunctional flavoproteins emit a light that the device then captures and quantifies. Mitochondria, the powerhouse of all cells, are critical in the production of ATP for energy and in the signaling process for cell death. Therefore, measuring mitochondrial functional health is an important indicator of cellular damage and the precursor to cell death. Since the OcuMet Beacon provides the operator with a quantitative FPF readout, physicians can, by taking multiple images over time, investigate the retinal metabolic change and thereby study the change due to disease and therapy. “An indication that a drug or intervention is working, or improving overall tissue metabolism, before structural changes become apparent, would be fantastic. I think this truly could be the next big leap in diagnosing, monitoring and treating retinal disease,” said Rosen. Drs. Rosen and Andrade Romo have no financial interest in the company. Author Dr. Victor Elner has a leadership position (Chief Scientific Officer) and financial interest in OcuSciences, Inc. About OcuSciences, Inc. OcuSciences, Inc., is a clinical-stage biotechnology company developing retinal imagers to identify metabolic dysfunction occurring in the retina for the detection of early disease. Its flagship device, the OcuMet Beacon, is being developed to automatically and non-invasively assess retinal metabolic function by detecting the degree of flavoprotein fluorescence (FPF), a well-studied precursor to retinal cell death, in a patient’s eye. OcuSciences has shown preliminary clinical utility in a number of different disease states, including diabetic retinopathy, glaucoma, and age-related macular degeneration. The study was conducted with IRB oversight as the device is not US-FDA approved. About the Mount Sinai Health System The Mount Sinai Health System is New York City's largest integrated delivery system encompassing seven hospital campuses, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The System includes approximately 6,600 primary and specialty care physicians; 10 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers View source version on OcuSciences, Inc.

Predict your next investment

The CB Insights tech market intelligence platform analyzes millions of data points on venture capital, startups, patents , partnerships and news mentions to help you see tomorrow's opportunities, today.

Expert Collections containing Ocusciences

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Ocusciences is included in 1 Expert Collection, including Diabetes.



1,750 items

CB Insights uses Cookies

CBI websites generally use certain cookies to enable better interactions with our sites and services. Use of these cookies, which may be stored on your device, permits us to improve and customize your experience. You can read more about your cookie choices at our privacy policy here. By continuing to use this site you are consenting to these choices.