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Founded Year

1972

Stage

Grant | Alive

Total Raised

$3.7M

Last Raised

$3.7M | 6 yrs ago

About Northwestern Medicine

Northwestern Medicine is a healthcare organization. The company provides a range of healthcare services, including patient care, medical research, and medical education. It primarily serves the healthcare industry. It was founded in 1972 and is based in Chicago, Illinois.

Headquarters Location

251 East Huron Street

Chicago, Illinois, 60611,

United States

312-926-2000

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Latest Northwestern Medicine News

Immune system in the blood of Alzheimer's patients found to be epigenetically altered

Feb 10, 2024

A new Northwestern Medicine study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Northwestern scientists theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors. It is possible that these findings implicate the peripheral immune response in Alzheimer's disease risk. We haven't yet untangled whether these changes are reflective of brain pathology or whether they precipitate the disease." David Gate, lead investigator, assistant professor of neurology at Northwestern University Feinberg School of Medicine The study was published Feb. 9 in Neuron. Previous research showed that many of the mutated genes putting a person at higher risk for Alzheimer's are in the immune system. But scientists primarily studied the central immune system in the brain because Alzheimer's is a brain disease. They have largely ignored the immune system in the blood, also known as the peripheral immune system. Gate decided to study the blood. He and colleagues discovered every immune cell type in Alzheimer's patients has epigenetic changes, indicated by open chromatin. Chromatin is the packaging of the DNA within cells. When chromatin is open -; or exposed -; the cells' genome is vulnerable to alterations. Then, Gate examined which genes are more open in these immune cells. He discovered that a receptor -; CXCR3 -; on the T cells was more exposed. Gate believes CXCR3 functions like an antenna on T cells that allows the cells to enter the brain. T cells do not normally enter the brain because they can cause inflammation. "The brain is emitting a signal that it is damaged, and the T cells are homing to that signal by their antenna, CXCR3," Gate said. Related Stories Gate also discovered epigenetic changes in inflammatory proteins in white blood cells called monocytes. "Altogether, these findings indicate that immune function in Alzheimer's patients is significantly altered," Gate said. "It could be that environmental factors, like pollutants, or infections that a person has in their lifetime cause these epigenetic changes." The findings revealed several genes that may be therapeutic targets for manipulating the peripheral immune system. Next steps in the research are preclinical studies using in vitro culture systems and animal models to test these targets. Other Northwestern authors include Abhirami Ramakrishnan, Natalie Piehl, Brooke Simonton, Milan Parikh, Ziyang Zhang, Victoria Teregulova and Lynn van Olst. The title of the article is "Epigenetic dysregulation in Alzheimer's disease peripheral immunity." The research is supported by National Institute of Neurological Disorders and Stroke grant NS112458 and National Institute on Aging grant AG078713, both of the National Institutes of Health, Bright Focus Foundation, Alzheimer's Association and Cure Alzheimer's Fund. Source:

Northwestern Medicine Frequently Asked Questions (FAQ)

  • When was Northwestern Medicine founded?

    Northwestern Medicine was founded in 1972.

  • Where is Northwestern Medicine's headquarters?

    Northwestern Medicine's headquarters is located at 251 East Huron Street, Chicago.

  • What is Northwestern Medicine's latest funding round?

    Northwestern Medicine's latest funding round is Grant.

  • How much did Northwestern Medicine raise?

    Northwestern Medicine raised a total of $3.7M.

  • Who are the investors of Northwestern Medicine?

    Investors of Northwestern Medicine include American Heart Association.

  • Who are Northwestern Medicine's competitors?

    Competitors of Northwestern Medicine include Froedtert Health, Advocate Health Care, Shirley Ryan AbilityLab, Cleveland Clinic, Advocate Aurora Health and 7 more.

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