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About Nile University

Nile University is a non-profit, research university in Egypt.On July 1st, 2020, Nile University was acquired by Honoris United Universities. The terms of the transaction were not disclosed.

Nile University Headquarter Location

Nile University Campus - Juhayna, Square on 26th of July Corridor, Sheikh Zayed

Giza,

Egypt

20 2 3854 1700

Latest Nile University News

Assessment of Ventricular Repolarization in Sickle Cell Anemia Patients: The Role of QTc Interval, Tp-e Interval and Tp-e/QTc Ratio and Its Gender Implication

Dec 6, 2020

Adeola Olubunmi Ajibare,1 Olatunde Peter Olabode,2 Emmanuel Yemi Fagbemiro,3 Olawale Mathias Akinlade,4 Adeseye Abiodun Akintunde,4 Oluwaseun Oyetope Akinpelu,5 Lawrence Aderemi Olatunji,6 Ayodele Olufemi Soladoye,6 Oladimeji George Opadijo4 1Department of Medicine, Lagos State University College of Medicine Ikeja, Lagos, Nigeria; 2Cardiology Unit, BT Diagnostics, LASUTH, Ikeja, Lagos, Nigeria; 3Department of Medicine, College of Medicine, Nile University, Abuja, Nigeria; 4Cardiology Unit, Department of Internal Medicine, LAUTECH Teaching Hospital, Ogbomoso, Nigeria; 5Department of Hematology, LAUTECH Teaching Hospital, Ogbomoso, Nigeria; 6Department of Physiology, University of Ilorin, Ilorin, Nigeria Correspondence: Adeola Olubunmi Ajibare Tel +234 8033251010 Email adeola.ajibare@lasucom.edu.ng Background: Many specific and non-specific electrocardiographic abnormalities including ventricular arrhythmias have been reported in subjects with sickle cell anemia (SCA). In SCA patients, cardiac electrical abnormalities may be the leading cause of increased risk of arrhythmias. The corrected QT (QTc) interval, peak to the end of the T wave (Tp-e) interval and associated Tp-e/QTc ratio are promising measures of altered ventricular repolarization and increased arrhythmogenesis risk. Aim: This study assessed ventricular repolarization abnormalities in subjects with SCA using the QTc interval, Tp-e interval and Tp-e/QTc ratio, and also evaluated the gender differences in these parameters, as well as their determinants. Methods: Sixty subjects with SCA and 60 healthy control subjects, matched for age and gender, were studied. All participants underwent physical examination, hematological and biochemical evaluation, and 12-lead electrocardiography (ECG) recording. QT and Tp-e intervals were measured from the ECG, and the QTc interval was calculated using Bazett’s formula. Tp-e/QT and Tp-e/QTc ratios were also derived. Results: QT and QTc intervals were prolonged in subjects with SCA. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were prolonged in male SCA subjects, with a paradoxical shortening in female SCA subjects. Plasminogen activator inhibitor-1 (PAI-1) was an independent determinant of QTc, while body mass index (BMI) was an independent determinant of both Tp-e interval and Tp-e/QTc ratio. Conclusion: Our results suggest an elevated risk for ventricular arrhythmogenesis in male SCA subjects. Furthermore, increased BMI and PAI-1 level are possible markers of ventricular repolarization abnormalities in SCA subjects. Keywords: arrhythmias, electrocardiography, sickle cell anemia, ventricular repolarization, QTc interval, Tp-e interval This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License . By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms .

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