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HEALTHCARE | Biotechnology

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Grant | Alive

Total Raised


Last Raised

$130K | 13 yrs ago

About NanoVector

NanoVector is a pre-clinical stage therapeutic drug company developing the world's first commercially viable biologic nanoparticle-based therapeutic drug delivery system. The NanoVector breakthrough technology is being used to develop a family of targeted drugs for late stage metastatic cancers using the plant virus nanoparticle (PVN). Effective targeting of chemotherapy has been highly sought after, because non-targeted chemotherapy causes considerable destruction of normal cells, resulting in severe adverse reactions. With targeting, anticancer agents can concentrate in a cancer cell resulting in extremely high efficacy, while reducing uptake of the anticancer agent by healthy cells; diminishing toxicity to normal cells and thus minimizing unpleasant side effects. The NanoVector drug delivery system is based on an engineered plant virus: Red clover necrotic mosaic virus (RCNMV). It is found in the human food chain, in such foods as cherries, and in some municipal water supplies in temperate climates. RCNMV is harmless to humans, will not replicate in a human cell, and has been found to be of low immunogenicity in testing of mice. It is a soil virus and one of the most robust viruses known. This plant virus has a 36 nanometer protein shell that with a hollow chamber that can be chemically opened and loaded with up to 1000 molecules of a small molecule drug. NanoVector's biologic nanoparticle has evolved for millions of years to become a quintessential intracellular delivery system that overcomes the manufacturing, loading, unloading and targeting technological challenges that plague other nanoscale delivery technologies. In addition, the PVN has two unique characteristics that make it nature's perfect drug delivery system. First and foremost of these unique characteristics, and an inherent property of the virus, is a built-in sensor-actuator system. When the therapeutic agent-carrying PVN enters a cell, it senses a change in chemical environment and automatically unloads its cargo. Therefore the highly toxic therapeutic agent is released only in a cell, never in the blood stream as with manmade particles that depend upon capsule degradation or require an external trigger to open the particles for the release of their contents. The second unique characteristic is a delayed drug release, enabling the PVN to travel deep within the cell prior to release, thereby avoiding efflux pumps in the cell membrane that could pump out the released drug. The biggest challenge in targeting cancer cells with a nanoparticle drug delivery system is identifying a cell surface receptor that is found on cancer cells but not targetable on healthy cells. NanoVector has successfully addressed this challenge by targeting the N-Cadherin cell surface receptor. In healthy cells N-cadherin is found in cell-to-cell junctions in the nervous system, opening the door for severe side effects if small molecule drugs or antibody-drug conjugates are used to target this molecular receptor. However the NanoVector nanoparticle is too large to enter the cell junctions of healthy cells, and therefore cannot target healthy cells. NanoVector has demonstrated that its PVN can effectively target N-cadherin on cancer cells but not in cell junctions between normal cells. The benefit derived from these features of the NanoVector nanoparticle and N-Cadherin targeting is the minimization of the horrendous side effects associated with free anti-cancer drugs in the blood stream.

NanoVector Headquarter Location

Box 98385

Raleigh, North Carolina, 27624,

United States


Latest NanoVector News

Epizyme Presents Updated Data from Ongoing Phase 1 Study of Tazemetostat Showing Objective Durable Responses in Relapsed or Refractory NonHodgkin Lymphoma

Dec 7, 2015

BRIEF-Nordic Nanovector updated data confirms Betalutin safety profile and promising efficacy “In this ongoing phase 1 study, we continue to observe meaningful and durable clinical activity with tazemetostat in NHL patients,” said Dr. Ribrag. “The phase 2 five-arm study, which is currently underway, will advance our understanding of the clinical utility of this agent in the different subsets of NHL. I believe tazemetostat has the potential to become an important new addition to the available treatment options for our patients.” Summary Results As of the November 7, 2015 cutoff, the following clinical data were reported: Twenty-one patients with relapsed or refractory NHL were enrolled into the phase 1 study; 16 of the 21 patients were response-evaluable as defined by the study protocol. Nine of 16 (56 percent) response-evaluable NHL patients achieved an objective response. On an intent-to-treat basis, seven of 12 (58 percent) response-evaluable NHL patients treated at or above the recommended phase 2 dose of 800 mg twice daily (BID) achieved an objective response. Four patients remained on study at data cutoff with ongoing objective responses, including three patients who had been on drug for at least 18 months. 800 mg BID showed superior tolerability, equivalent anti-tumor activity and equivalent pharmacodynamic activity as compared to the 1600 mg BID dose. The majority of adverse events were grade 1 or grade 2 within the 55 patients with NHL and solid tumors who were evaluable for safety. The most common adverse events, regardless of attribution, were asthenia, anorexia, thrombocytopenia, nausea, constipation, diarrhea, and vomiting. Four grade 3 or greater treatment-related adverse events have been observed including one each of: grade 3 hypertension, grade 3 liver function test elevation, grade 4 thrombocytopenia, and grade 4 neutropenia. Study Design This open-label, multi-center, phase 1 study is investigating tazemetostat as monotherapy in patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma or advanced solid tumors. The study objectives include identification of the recommended phase 2 dose or maximum tolerated dose, safety, tolerability, pharmacokinetics and preliminary evaluation of anti-tumor activity. Five cohorts were studied in the dose escalation phase: 100 mg, 200 mg, 400 mg, 800 mg and 1600 mg; and two cohorts, 800 mg and 1600 mg, were evaluated in the dose expansion phase. All doses were given twice daily. In addition, the study included two clinical pharmacology sub-studies: one for food effect and the other for drug-drug interaction. In the food effect sub-study, patients received a single 200 mg dose of tazemetostat either fasted or immediately after a high-fat breakfast in a randomized crossover fashion with seven days between doses. Patients received 400 mg BID after completing the seven-day crossover component of the study. Five of the 21 NHL patients were in the food effect sub-study. Expanded Tazemetostat Registration-Supporting Phase 2 Program in NHL Epizyme is conducting an international, multi-center, phase 2 study comprised of five independent arms. This study, which began enrolling patients in the second half of 2015, will assess the safety and efficacy of 800 mg BID of tazemetostat in patients with relapsed or refractory NHL, stratified by cell of origin and EZH2 mutation status. Epizyme plans to present interim results from the phase 2 study at a medical conference in mid-2016. About EZH2 in Cancer EZH2 is a histone methyltransferase (HMT) that is increasingly understood to play a potentially oncogenic role in a number of cancers. These include Non-Hodgkin Lymphoma, INI1-deficient cancers such as malignant rhabdoid tumors, epithelioid sarcomas and synovial sarcoma; and a range of other solid tumors. About Tazemetostat Epizyme is developing tazemetostat for the treatment of non-Hodgkin lymphoma patients and patients with INI1-deficient solid tumors. Tazemetostat is a first-in-class small molecule inhibitor of EZH2 created by Epizyme using its proprietary product platform. In many human cancers, aberrant EZH2 enzyme activity results in misregulation of genes that control cell proliferation resulting in the rapid and unconstrained growth of tumor cells. Tazemetostat is the WHO International Non-Proprietary Name (INN) for EPZ-6438. Additional information about this program, including clinical trial information, may be found here: About Epizyme, Inc. Epizyme, Inc. is a clinical-stage biopharmaceutical company creating novel epigenetic therapeutics for cancer patients. Epizyme has built a proprietary product platform that the Company uses to create small molecule inhibitors of chromatin modifying proteins (CMPs), such as histone methyltransferases or HMTs. CMPs are part of the system of gene regulation, referred to as epigenetics, that controls gene expression. Genetic alterations can result in changes to the activity of CMPs, making them oncogenic (cancer-causing). By focusing on the genetic drivers of cancers, Epizyme's targeted science seeks to match the right medicines with the right patients. For more information, visit and connect with us on Twitter at @EpizymeRx. Cautionary Note on Forward-Looking Statements Any statements in this press release about future expectations, plans and prospects for Epizyme, Inc. and other statements containing the words "anticipate," "believe," "estimate," "expect," "intend," "may," "plan," "predict," "project," "target," "potential," "will," "would," "could," "should," "continue," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties inherent in the initiation of future clinical studies or expansion of ongoing clinical studies; availability and timing of data from ongoing clinical studies; whether interim results from a clinical trial such as the results referred to in this release will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products; development progress of the Company’s companion diagnostics, availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; other matters that could affect the availability or commercial potential of the Company’s therapeutic candidates or companion diagnostics; and other factors discussed in the "Risk Factors" section of the company’s Form 10-Q filed with the SEC on November 9, 2015, and in our other filings from time to time with the SEC. In addition, the forward-looking statements included in this press release represent the Company's views as of the date hereof. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date hereof. View source version on Epizyme, Inc.

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Expert Collections containing NanoVector

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NanoVector is included in 2 Expert Collections, including Cancer.



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Pharmaceutical and biotechnology companies with cancer therapy drug candidates.


Biopharma Tech

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Companies involved in the research, development, and commercialization of chemically- or biologically-derived therapeutic & theranostic drugs. Excludes vitamins/supplements, CROs/clinical trial services.

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