Source:
Kenet G, et al. Abstract LB 01.1 Presented at: International Society on Thrombosis and Haemostasis 2022 Congress; July 9-13, 2022; London. Disclosures: Sanofi funded this study. Kenet reports consultant, advisory board or speakers bureau roles with or research funding from Alnylam, Bayer, BioMarin Pharmaceutical, BPL Plasma, CSL Behring, NovoNordisk, Opko Biologics, Pfizer, Takeda, Roche, Sanofi, Shire and uniQure. Please see the abstract for all other researchers’ relevant financial disclosures. ADD TOPIC TO EMAIL ALERTS
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Almost two-thirds (63.1%) had no treated bleeds while receiving prophylactic fitusiran. Fitusiran demonstrated “statistically significant improvement in health-related quality-of-life measures.”
Once-monthly prophylactic fitusiran resulted in significantly fewer bleeding episodes compared with episodic-based on-demand treatment among males with hemophilia A or B with or without inhibitors, according to results of a phase 3 study. Kenet G, et al. Abstract LB 01.1 Presented at: International Society on Thrombosis and Haemostasis 2022 Congress; July 9-13, 2022; London. Use of fitusiran (Sanofi) also led to significantly improved health-related quality-of-life scores, findings presented at International Society on Thrombosis and Haemostasis 2022 Congress showed. Background
Prophylaxis is the standard-of-care treatment for patients with hemophilia, according to Gili Kenet, MD, director of Israel National Hemophilia Center at Sheba Medical Center and head of Amalia Biron Thrombosis Research Institute of Tel Aviv University. Historically, the aim of prophylaxis has been to replace the missing clotting factor that corresponded with the type of disease with the intent of preventing bleeding. “Now the bar is rising because the regular administration of hemostatic agents has the goal of preventing bleeding in patients with hemophilia while allowing them to lead active lives and achieve quality of life that is comparable with patients who do not have hemophilia,” Kenet said during a presentation. Fitusiran — a subcutaneous small-interference RNA therapy — has “raised the expectations” of what is possible for the treatment of hemophilia A and B, she said. Prophylactic use of the investigational treatment has shown the ability to significantly reduce annualized bleeding rates compared with on-demand treatment options in previous phase 3 studies , she added. “Fitusiran targets antithrombin to restore specific thrombi generation and rebalance hemostasis without actually replacing the missing population factors,” Kenet said. Methodology
The multicenter phase 3 ATLAS-PPX trial enrolled 80 males aged 12 years or older with hemophilia A or B, with (n = 30) or without (n = 50) inhibitors, who had received previous treatment with prophylactic factor or bypassing agents. Kenet and colleagues divided the study into an initial standard-of-care period, when patients continued receiving prophylactic factor or bypassing agents for 6 months, and a treatment period, when patients began taking prophylactic once-monthly subcutaneous fitusiran dosed at 80 mg starting at month 7. Annualized bleeding rate during the standard-of-care and treatment periods served as the study’s primary endpoint. Secondary endpoints included spontaneous annualized bleeding rate, annualized bleeding rate in joints, health-related quality of life and safety. Key findings
Sixty-five patients remained eligible for primary endpoint analysis of annualized bleeding rate, including 50 patients with hemophilia A and 15 with hemophilia B. Investigators divided the study into two cohorts — 19 patients with inhibitors (mean age, 27.8 ± 17.1 years) and 46 patients without inhibitors (mean age, 23.5 ± 7.3 years). Researchers reported a median annualized bleeding rate of 0 (95% CI, 0-2.3) among patients who received fitusiran prophylaxis compared with 4.4 (95% CI, 2.2-10.9) for those who received prophylactic factor or bypassing agents. This equaled a statically significant 61.1% reduction in annualized bleeding rate for patients who received fitusiran (P -= .0008). Additionally, 41 patients (63.1%) had no treated bleeds while receiving prophylactic fitusiran during the treatment period. Investigators noted that spontaneous annualized bleeding rate, annualized bleeding rate in joints and health related quality-of-life assessments all showed significant improvement during the treatment period with fitusiran. This included median spontaneous and joint bleeding rates of zero during the treatment period compared with 2.2 for both values during the standard-of-care period. Safety analysis showed 71.6% of patients had a treatment-related adverse event during the fitusiran treatment period, compared with 33.8% in the standard-of-care period. Serious treatment-related adverse events occurred among 13.4% of patients during the fitusiran treatment period, including two patients who discontinued the therapy. No treatment-related deaths occurred during either the standard-of-care or fitusiran treatment periods. Clinical implications
Fitusiran prophylaxis resulted in statistically significant reductions in bleeding events vs. standard-of-care treatment among patients with hemophilia A or B, regardless of whether they developed inhibitors, Kenet noted. “[This] resulted in statistically significant improvement in health-related quality-of-life measures,” she said. “Reported adverse events were generally consistent with previously identified risks of fitusiran or what is anticipated in an adult and adolescent population of patients with severe hemophilia A or B, with or without inhibitors.”
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Fitusiran prophylaxis leads to 61% reduction in bleeds among people with hemophilia A or B

Professor Meoli Kashorda, Executive Director of KENET
Telco Systems, a provider of innovative SDN/NFV, CE 2.0, MPLS and IP solutions has completed an upgrade of the carrier Ethernet network of Kenya Education Network (KENET), the National Research and Education Network (NREN) of Kenya, from 10GE to 100GE. As the NREN of Kenya, KENET provides high-speed Internet access and data center services to member university campuses and research facilities across the country and interconnectivity with other NRENs around the world. KENET also provides shared cloud-based services, including co-location of servers, dedicated virtual servers for e-learning systems and video and web conferencing. Three years ago, Telco Systems supplied KENET with its IP/MPLS technologies that were used to build KENET’s 10GE carrier Ethernet network, which was managed and fully orchestrated by an aggregation and demarcation solution. For this 100GE network upgrade, Telco Systems delivered its T-Metro 8100 service aggregation platform and cloud gateway. T-Metro 8100 provides carrier Ethernet 2.0, MPLS, IP (Layer 3) and SDN capabilities and offers massive service scalability and carrier class resiliency. T-Metro 8100 includes industry leading features like QoS, SLA management and OAM. It is built with a modular architecture designed with future expansion capabilities, such as adding compute nodes or new networking capabilities. For KENET, these T-Metro 8100 devices are managed and orchestrated by Telco Systems’ EdgeGenie Orchestrator service provisioning management system, which was also previously deployed in 2013 when Telco Systems originally supplied KENET’s carrier Ethernet network. By upgrading its network capacity to 100GE, KENET has been able to improve the quality of existing services, offer additional advanced services and meet the growing bandwidth requirements of its education and research institution customers and their users. “We have been working with Telco Systems for five years now and we have developed trust and confidence in the company and its technologies,” stated Professor Meoli Kashorda, Executive Director of KENET. “Telco Systems has played a strategic role in the expansion of our network and the services from 1GE to 10GE and now to 100GE and I am certain that the company will continue to do so for many years to come.”
“More and more service providers around the world are upgrading their network capacities to 100GE in order to better serve their customers and grow their businesses and we are proud to be supporting KENET in this important move,” said Ariel Efrati, CEO at Telco Systems. “We are experiencing strong traction in the education vertical and our T-Metro 8100 solution is well-positioned to help network operators serving this market space, especially the government E-Rate projects in the United States, to upgrade their networks and improve the performance of their services.”
Edited by Neo Sesinye

Telco systems upgrades carrier ethernet network for Kenet Kenya

Kenya Education Network Trust network gains 100GE upgrade from BATM’s Telco Systems
Kenya Education Network Trust network gains 100GE upgrade from BATM’s Telco Systems
17 January, 2019 at 1:16 PM
Posted by: Anasia D'mello
Dr Zvi Marom of BATM
BATM Advanced Communications Limited, a provider of real-time technologies for networking solutions and medical laboratory systems, announces that Telco Systems, a wholly-owned high-end software development and design business within the Group’s Networking & Cyber division, has completed an upgrade of the Carrier Ethernet network of  Kenya Education Network  (KENET), the National Research and Education Network (NREN) of Kenya, from 10GE to 100GE. As the NREN of Kenya, KENET provides high-speed Internet access and data centre services to member university campuses and research facilities across the country and interconnectivity with other NRENs around the world. KENET also provides shared cloud-based services, including co-location of servers, dedicated virtual servers for e-learning systems and video and web conferencing. As announced in June 2016, the Group previously supplied KENET with its 10GE Carrier Ethernet network. For this 100GE network upgrade, Telco Systems delivered its  T-Metro 8100  service aggregation platform and cloud gateway, which offers significant service scalability and carrier class resiliency with modular options for future expansion capabilities. The T-Metro 8100 devices are managed and orchestrated by Telco Systems’  EdgeGenie Orchestrator  service provisioning management system, which the Group also deployed with the original installation. By upgrading its network capacity to 100GE, KENET has been able to improve the quality of existing services, offer additional advanced services and meet the growing bandwidth requirements of its education and research institution customers and their users. Ariel Efrati
“We have been working with Telco Systems for five years now and we have developed trust and confidence in the company and its technologies,” states Professor Meoli Kashorda, executive director of KENET. “Telco Systems has played a strategic role in the expansion of our network and the services from 1GE to 10GE and now to 100GE and I am certain that the company will continue to do so for many years to come.”
“More and more service providers around the world are upgrading their network capacities to 100GE in order to better serve their customers and grow their businesses and we are proud to be supporting KENET in this important move,” says Ariel Efrati, CEO at Telco Systems. “We are experiencing strong traction in the education vertical and our T-Metro 8100 solution is well-positioned to help network operators serving this market space, especially the government E-Rate projects in the United States, to upgrade their networks and improve the performance of their services.”
Dr Zvi Marom, CEO of BATM, comments: “We are pleased to have delivered this network upgrade in Kenya, which will improve the IT infrastructure of education institutions throughout the country. Our Carrier Ethernet portfolio provides the foundation on which our Networking business is built, and we continue to strengthen this base by developing industry-leading solutions that we are providing to clients worldwide.”
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Kenya Education Network Trust network gains 100GE upgrade from BATM’s Telco Systems

KENET, T-Metro unite to give Kenya's education a boost
Published on 16 January 2019
By Staff Writer
SDN/NFV provider Telco Systems has completed an upgrade of the carrier Ethernet network of Kenya Education Network (KENET), the National Research and Education Network (NREN) of Kenya, from 10GE to 100GE. According to information supplied, as the NREN of Kenya, KENET provides high-speed Internet access and data centre services to member university campuses and research facilities across the country and interconnectivity with other NRENs around the world. KENET also provides shared cloud-based services, including co-location of servers, dedicated virtual servers for e-learning systems and video and web conferencing. A statement released by the company explains that three years ago, Telco Systems supplied KENET with its IP/MPLS technologies that were used to build KENET's 10GE carrier Ethernet network, which was managed and fully orchestrated by an aggregation and demarcation solution. READ MORE
For this 100GE network upgrade, Telco Systems delivered its T-Metro 8100 service aggregation platform and cloud gateway. For KENET, these T-Metro 8100 devices are managed and orchestrated by Telco Systems' EdgeGenie Orchestrator service provisioning management system, which was also previously deployed in 2013 when Telco Systems originally supplied KENET's carrier Ethernet network. By upgrading its network capacity to 100GE, KENET has been able to improve the quality of existing services, offer additional advanced services and meet the growing bandwidth requirements of its education and research institution customers and their users. "We have been working with Telco Systems for five years now and we have developed trust and confidence in the company and its technologies," stated Professor Meoli Kashorda, Executive Director of KENET. "Telco Systems has played a strategic role in the expansion of our network and the services from 1GE to 10GE and now to 100GE and I am certain that the company will continue to do so for many years to come." Ariel Efrati, CEO at Telco Systems, added, "More and more service providers around the world are upgrading their network capacities to 100GE in order to better serve their customers and grow their businesses and we are proud to be supporting KENET in this important move," said Ariel Efrati, CEO at Telco Systems. "We are experiencing strong traction in the education vertical and our T-Metro 8100 solution is well-positioned to help network operators serving this market space, especially the government E-Rate projects in the United States, to upgrade their networks and improve the performance of their services." ALSO ON ITWEB AFRICA

KENET, T-Metro unite to give Kenya's education a boost

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Students are to enjoy a step change in their Internet access and speeds, following the partnership between Kenya Education Network (KENET) and Liquid Telecom Kenya that is migrating Kenya’s education and research institutions onto connections that are up to 25 times faster than were possible in the past.The new connections are increasing the total Internet capacity distributed to KENET member institutions using Liquid Telecom Kenya’s network from as little as 200 megabytes in 2009 to now 6,000 megabytes in 2016, as each member is progressively connected at higher speeds.At the end of a three year programme of connection, the partnership will deliver high speed Internet to more than 500,000 students and 20,000 members of staff across Kenya, most of who were previously suffering challenges in Internet access.“The upgrades have been made essential by the changing educational landscape,” said Professor Meoli Kashorda, KENET Executive Director, who said the majority of students and staff now rely on the Internet for learning and research: “They now view it as a necessity.”“The increase in Internet traffic has been phenomenal, with students acquiring devices that can access Wi-Fi, while institutions are using the Internet more. The Internet is changing ways of learning,” he said.This shift to greater Internet use ties with research showing that Internet access is key to delivering improved grades and academic performance. One study at the Federal Urdu University in Pakistan found that students who spend more hours studying on the Internet were averaging B+ to A- grades, while those who used it less were averaging B to B+.According to fourth year student Lewis Muchiri from Kenya Methodist University, the faster Internet speeds have transformed his own learning. “With faster internet, I am accessing research papers, E-books and other learning materials that have helped me save time and focus more on my studies. We used to spend a lot of time waiting for pages to load, but today, with faster Wi-Fi, we even study from our smartphones,” he said.Providing faster and easier Internet access to students in Kenya and the rest of Africa is a key aim for Liquid Telecom.“Getting the country’s educational institutions and students onto high-speed Internet is an important step for Liquid Telecom Kenya, and aligns with our mission of achieving Internet access for every African and accelerating the benefits to society and the economy that come from high-quality Internet,” said Ben Roberts, CEO Liquid Telecom Kenya.KENET’s upgrade of its connections through the deployment of the new Liquid Telecom Kenya technology follows from a partnership of several years between the two organisations.KENET is mandated to provide affordable and cost-effective Internet connections that serve large numbers of students simultaneously. “Liquid Telecom Kenya has been our primary and back-up provider for a long time and its network is the most affordable of all providers,” said Professor Kashorda.Liquid Telecom now provides 70 per cent of KENET’s leased line Internet capacity, and is in the process of upgrading the distribution network capacity by installing new equipment on member sites and increasing the reliability and quality of connection.

Liquid Telecom Kenya and KENET boost Internet for students

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