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Founded Year



Series E - II | Alive

Total Raised


Last Raised

$7.6M | 8 yrs ago

About Isarna Therapeutics

Isarna Therapeutics has a commitment to developing TGF-β inhibitors that stimulate the human immune system to effectively fight cancer. The company is advancing a unique pipeline of novel oligonucleotides and combination modalities to transcend clinical response and improve patient outcomes.

Isarna Therapeutics Headquarter Location

Leopoldstrasse 254-256

Munich, D-80807,



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Expert Collections containing Isarna Therapeutics

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Isarna Therapeutics is included in 2 Expert Collections, including Cancer.



4,784 items

Pharmaceutical and biotechnology companies with cancer therapy drug candidates.


Biopharma Tech

15,535 items

Companies involved in the research, development, and commercialization of chemically- or biologically-derived therapeutic & theranostic drugs. Excludes vitamins/supplements, CROs/clinical trial services.

Isarna Therapeutics Patents

Isarna Therapeutics has filed 8 patents.

The 3 most popular patent topics include:

  • Diseases of the eye and adnexa
  • Clusters of differentiation
  • Ophthalmology
patents chart

Application Date

Grant Date


Related Topics




Diseases of the eye and adnexa, Transcription factors, Ophthalmology, Molecular biology, Visual system


Application Date


Grant Date



Related Topics

Diseases of the eye and adnexa, Transcription factors, Ophthalmology, Molecular biology, Visual system



Latest Isarna Therapeutics News

Isarna Therapeutics Announces First Patient Enrolled in International Phase 2a Clinical Study in Ophthalmology Indications Wet AMD and DME

Nov 30, 2021

November 30, 2021 05:00 AM Eastern Standard Time MUNICH--( BUSINESS WIRE )-- Isarna Therapeutics today announced the enrollment of the first patient in the BETTER Study, a parallel, two-segment Phase 2a clinical study to evaluate Isarna’s lead candidate ISTH0036 in patients with wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME). The study aims to enroll as many as 24 patients for each indication and will be led by internationally renowned experts at clinical trial centers in Austria and India with lead investigators Prof. Matthias Bolz and Priv. Doz. The study’s objective is to evaluate ISTH0036 in these two indications and gain data that will enable the transition into a Phase2b/3 clinical trial. “Based on the positive results from our Phase 1 study supporting the safety of ISTH0036 and the encouraging data from preclinical studies in retinal disease, Isarna has committed to exploring ISTH0036 in ophthalmic indications where TGF-β plays a vital role in disease progression and where we see the greatest potential value for patients,” said Prof. Marion Munk, CMO of Isarna Therapeutics. The Phase 2a trial will gather data on the reduction of retinal fluid and central macular thickness (CMT) as the primary endpoint and improvement of visual acuity (VA) as a secondary endpoint during a treatment period of seven months, followed by a two-month safety follow-up. The trial aims to explore the prevention of fibrosis and epithelial-mesenchymal transition as a key differentiator to currently approved anti-angiogenic therapies, mostly targeting Vascular Endothelial Growth Factors (VEGF). Furthermore, the durability of the antisense therapy ISTH0036 will be evaluated, which showed target suppression in preclinical models for more than four months. Patients selected for the trials will include both newly diagnosed, treatment naïve patients and those who have already been treated with anti-VEGF therapeutics. Wet AMD causes reduced vision in the center of the eye and affects as many as 190 million people globally1. Macular edema occurs when there is abnormal leakage and accumulation of fluid in the macula from damaged, dysfunctional blood vessels in the retina. A common cause of macular edema is diabetes, which is the leading cause of irreversible blindness in mature adults in the U.S.2 Both diseases can be treated with a range of anti-VEGF drugs however, these therapeutics are not able to maintain visual acuity as many patients develop fibrosis during the disease progression. “Fibrosis is a primary concern in long-term retina pathologies and is a key driver of significant vision loss even under optimal gold-standard therapy with anti-VEGF. ISTH0036 could be the first drug that targets and prevents development of fibrosis and therefore may become a unique and promising new therapy for retinal indications,” said Dr. René Rückert, COO of Isarna Therapeutics. Isarna has developed ISTH0036 to target the transforming growth factor-beta (TGF-β), a protein which is chronically elevated in ophthalmic, fibrotic, immunologic, and cancerous diseases. ISTH0036 suppresses TGF-β protein production via well-studied antisense mechanisms. *** About Isarna Isarna Therapeutics was built on profound knowledge in antisense oligonucleotide design and therapeutic development of this innovative compound class. Today, Isarna is developing a portfolio of antisense therapies targeting an emerging therapeutic field in human biology: TGF-β signaling. Precise modulation of TGF-β pathways using antisense therapy may result in safer and more effective treatment options for a broad range of indications. Currently, Isarna is focusing on ophthalmology; its lead compound, ISTH0036, has entered Phase 2a clinical development in the blockbuster indications wet AMD and DME. In addition, Isarna has established a portfolio of antisense compounds addressing three important isoforms of TGF-β to treat fibrotic liver disease, such as NASH, and various forms of cancer. 1. Bourne RR, Stevens GA, White RA, Smith JL, Flaxman SR, Price H, et al. Causes of vision loss worldwide, 1990-2010: a systematic analysis. Lancet Glob Health. 2013;1:e339–49. 2. Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA. 2004 Apr 21;291(15):1900-1. doi: 10.1001/jama.291.15.1900. PMID: 15108691. Contacts

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Isarna Therapeutics Rank

  • When was Isarna Therapeutics founded?

    Isarna Therapeutics was founded in 1998.

  • Where is Isarna Therapeutics's headquarters?

    Isarna Therapeutics's headquarters is located at Leopoldstrasse 254-256, Munich.

  • What is Isarna Therapeutics's latest funding round?

    Isarna Therapeutics's latest funding round is Series E - II.

  • How much did Isarna Therapeutics raise?

    Isarna Therapeutics raised a total of $112.62M.

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