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HEALTHCARE | Drug Development
io-therapeutics.com

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Stage

Unattributed | Alive

Total Raised

$440K

Last Raised

$440K | 8 yrs ago

About Io Therapeutics

Io Therapeutics was founded to develop and commercialize a series of retinoid and rexinoid compounds originally discovered at Allergan. The company's strategy includes expanding the uses of the compounds in its pipeline to address new indications. IRX4204, an RXR agonist originally developed for treatment of cancers, is being developed for neurodegenerative and autoimmune diseases. IRX4310, an RAR antagonist originally developed for dermatologic diseases is being developed for prophylaxis of chemotherapy-induced neutropenia. IRX5183, an RARa agonist orginially dvelped for treatemsnt of cancers, is being developed as a traetment for autimmune diseasses.

Io Therapeutics Headquarter Location

1805 E Garry Avenue Suite 110

Santa Ana, California, 92705,

United States

650-219-5973

Latest Io Therapeutics News

Io Therapeutics, Inc. Reports Data Demonstrating That the Company's Candidate Treatment for Multiple Sclerosis, IRX4204, Promotes Repair of Damaged Myelin

Sep 16, 2016

SANTA ANA, CA--(Marketwired - Sep 16, 2016) - Io Therapeutics, Inc., today, reported data demonstrating that the company's experimental rexinoid nuclear receptor (RXR) agonist compound, IRX4204, promotes repair of myelin in a mouse model of multiple sclerosis (MS). Myelin is a tissue in the brain and spinal cord which is damaged by an autoimmune process in MS, resulting in progressive disability and death. Finding new treatments, which promote repair of myelin is a major focus of current MS research. The company's data were presented at the 32nd Congress of The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), currently being held in London, England. The reported studies were supported by funding from the US National Multiple Sclerosis Society's Fast Forward Program. About RXR in MS and the Effects of IRX4204 In MS, autoimmune processes damage the myelin sheath surrounding nerve fibers, resulting in dysfunction of signal transmission in the brain and spinal cord. Myelin damage contributes to physical disability in MS patients. Many currently available treatments for MS target the autoimmune processes, but to date, none have been conclusively demonstrated to promote repair of damaged myelin in MS patients. The company has previously reported that IRX4204 has beneficial effects on autoimmunity, and protects against loss of neurons, in animal models of MS. The current data, showing that IRX4204 promotes repair of damaged myelin in an animal model of MS, demonstrates a third critically important mechanism of action of the drug as a promising potential treatment for MS. "The Society is pleased with the rapid progress made by Io Therapeutics, enabling presentation of their data at ECTRIMS, a major research conference, so soon after initiating the project," said Mark Allegretta, Ph.D., Associate Vice President, Commercial Research for the National MS Society. He continued, "In addition, we are encouraged by their data demonstrating that IRX4204 has the potential not only to suppress the autoimmune aspect of MS-like disease in mice, but also to protect against neuronal loss and promote repair of damaged myelin, thereby possibly slowing or even stopping progression of the disease. " Dr. Martin E. Sanders, Chairman and Chief Executive Officer of Io Therapeutics said, "Io Therapeutics is grateful to the National MS Society Fast Forward Program for its support of the company's evaluation of IRX4204 as a new treatment for MS. We are impressed at the preclinical results we have obtained, which demonstrate immunosuppressive, neuroprotective, and myelin reparative activities in a single compound, a unique and promising pharmacologic profile for a candidate treatment for MS. IRX4204 has already completed phase 1 clinical trials in other indications, in which it was safe and well tolerated. We are eager to advance IRX4204 into phase 2 clinical trials in MS patients. " About Io Therapeutics Io Therapeutics, Inc. is a privately held company headquartered in Santa Ana, California, focused on the development of novel treatments for cancers, neurodegenerative diseases, and autoimmune diseases. About the National Multiple Sclerosis Society The Society mobilizes people and resources so that everyone affected by multiple sclerosis can live their best lives as we stop MS in its tracks, restore what has been lost and end MS forever. Last year alone, through its comprehensive nationwide network of services, the Society devoted $122.2 million to connect more than million individuals to the people, information and resources they need. To move closer to a world free of MS, the Society also invested $56 million to support more than 380 new and ongoing research projects around the world. We are united in our collective power to do something about MS now and end this disease forever. Learn more at www.nationalMSsociety.org . About Fast Forward Fast Forward, LLC is a nonprofit organization established by the National Multiple Sclerosis Society in order to accelerate the development of treatments for MS. Fast Forward connects university-based MS research with private-sector drug development and funds small biotechnology/pharmaceutical companies to develop innovative MS therapies and repurpose FDA-approved drugs as new treatments for MS. Forward Looking Statements This new release contains "forward-looking statements" within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. For more information on Io Therapeutics see: www.io-therapeutics.com Contact Information

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Expert Collections containing Io Therapeutics

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Io Therapeutics is included in 2 Expert Collections, including Cancer.

C

Cancer

4,784 items

Pharmaceutical and biotechnology companies with cancer therapy drug candidates.

B

Biopharmaceuticals

5,882 items

Companies involved in the research, development, and commercialization of chemically- or biologically-derived therapeutic & theranostic drugs. Excludes vitamins/supplements, CROs/clinical trial services.

Io Therapeutics Patents

Io Therapeutics has filed 77 patents.

The 3 most popular patent topics include:

  • Transcription factors
  • Autoimmune diseases
  • Immune system
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Autoimmune diseases, Immunology, Immune system, Inflammations, Transcription factors

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Autoimmune diseases, Immunology, Immune system, Inflammations, Transcription factors

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