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About Instrumentation Laboratories

Provider of medical instruments for blood diagnosis.

Instrumentation Laboratories Headquarters Location

Via le Monza 338

Milan, 20128,

Italy

39 02 25221

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Instrumentation Laboratories Patents

Instrumentation Laboratories has filed 26 patents.

The 3 most popular patent topics include:

  • Blood tests
  • Coagulation system
  • Coagulopathies
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Application Date

Grant Date

Title

Related Topics

Status

2/28/2020

8/2/2022

Blood tests, Sensors, Coagulation system, Coagulopathies, Anticoagulants

Grant

Application Date

2/28/2020

Grant Date

8/2/2022

Title

Related Topics

Blood tests, Sensors, Coagulation system, Coagulopathies, Anticoagulants

Status

Grant

Latest Instrumentation Laboratories News

Aspirin as an Adjunctive Pharmacologic Therapy Option for COVID-19: Anti-Inflammatory, Antithrombotic, and Antiviral Effects All in One Agent

Dec 6, 2021

Dr Gurbel has received consulting fees and/or honoraria from Bayer, Otitopic, Janssen, UpToDate, US WorldMeds, Hikari Dx, and Medicure; institutional research grants from the National Institutes of Health, Haemonetics, Bayer, Medicure, Instrumentation Laboratories, US WorldMeds, Amgen, Idorsia, Otitopic, and Janssen. Dr Schror has received personal fees from Bayer, during the conduct of the study. The authors report no other conflicts of interest in this work. References 1. Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(23):2950–2973. doi:10.1016/j.jacc.2020.04.031 2. Cuker A, Tseng EK, Nieuwlaat R, et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv. 2021;5:872–888. doi:10.1182/bloodadvances.2020003763 3. Bianconi V, Violi F, Fallarino F, Pignatelli P, Sahebkar A, Pirro M. Is acetylsalicylic acid a safe and potentially useful choice for adult patients with COVID-19? Drugs. 2020;80:1383–1396. doi:10.1007/s40265-020-01365-1 4. Grabowski F, Preibisch G, Giziński S, et al. SARS-CoV-2 variant of concern 202012/01 has about twofold replicative advantage and acquires concerning mutations. Viruses. 2021;1(13):392. doi:10.3390/v13030392 5. Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends Immunol. 2020;41:1100–1115. doi:10.1016/j.it.2020.10.004 6. Walls AC, Park YJ, Tortorici MA, et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020;181:281–292. doi:10.1016/j.cell.2020.02.058 7. Kircheis R, Haasbach E, Lueftenegger D, et al. NF-κB pathway as a potential target for treatment of critical stage COVID-19 patients. Front Immunol. 2020;11:598444. doi:10.3389/fimmu.2020.598444 8. He L, Ding Y, Zhang Q, et al. Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS. J Pathol. 2006;210:288–297. doi:10.1002/path.2067 9. Poppe M, Wittig S, Jurida L, et al. The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog. 2017;13:e1006286. doi:10.1371/journal.ppat.1006286 10. Jayarangaiah A, Kariyanna PT, Chen X, et al. COVID-19-associated coagulopathy: an exacerbated immunothrombosis response. Clin Appl Thromb Hemost. 2020;26:1076029620943293. doi:10.1177/1076029620943293 11. Hue S, Beldi-Ferchiou A, Bendib I, et al. Uncontrolled Innate and Impaired adaptive immune responses in patients with COVID-19 acute respiratory distress syndrome. Am J Respir Crit Care Med. 2020;202:1509–1519. doi:10.1164/rccm.202005-1885OC 12. Yadav H, Kor DJ. Platelets in the pathogenesis of acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2015;309:L915–23. doi:10.1152/ajplung.00266.2015 13. Zhang S, Liu Y, Wang X, et al. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol. 2020;13:120. doi:10.1186/s13045-020-00954-7 14. Kreutz RP, Tantry US, Bliden KP, Gurbel PA. Inflammatory changes during the ‘common cold’ are associated with platelet activation and increased reactivity of platelets to agonists. Blood Coagul Fibrinolysis. 2007;18:713–718. doi:10.1097/MBC.0b013e328201c77e 15. Gurbel PA, deFilippi CR, Bliden KP, Tantry US. HIV infection, ACS, PCI and high platelet reactivity: ingredients for a perfect thrombotic storm. Eur Heart J. 2017;38:1687–1689. doi:10.1093/eurheartj/ehw630 16. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017;544:105–109. doi:10.1038/nature21706 17. Gustafson D, Raju S, Wu R, et al. Overcoming barriers: the endothelium as a linchpin of coronavirus disease 2019 pathogenesis? Arter Thromb Vasc Biol. 1818–1829;2020(40):548. 18. Helms J, Tacquard C, Severac F, et al. ; CRICS TRIGGERSEP Group. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020;46:1089–1098. doi:10.1007/s00134-020-06062-x 19. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135:2033–2040. doi:10.1182/blood.2020006000 20. Janiuk K, Jabłońska E, Garley M. Significance of NETs formation in COVID-19. Cells. 2021;10:151. doi:10.3390/cells10010151 21. Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. 2020;383:120–128. doi:10.1056/NEJMoa2015432 22. Do Espírito Santo DA, Lemos ACB, Miranda CH. In vivo demonstration of microvascular thrombosis in severe COVID-19. J Thromb Thrombolysis. 2020;50:790–794. doi:10.1007/s11239-020-02245-x 23. Satturwar S, Fowkes M, Farver C, et al. Postmortem findings associated with SARS-CoV-2: systematic review and meta-analysis. Am J Surg Pathol. 2021;45:587–603. doi:10.1097/PAS.0000000000001650 24. Gurbel PA, Bliden KP, Schrör K. Can an old ally defeat a new enemy? Circulation. 2020;142:315–317. doi:10.1161/CIRCULATIONAHA.120.047830 25. Tantry US, Mahla E, Gurbel PA. Aspirin resistance. Prog Cardiovasc Dis. 2009;52:141–152. doi:10.1016/j.pcad.2009.05.001 26. Boutaud O, Sosa IR, Amin T, et al. Inhibition of the biosynthesis of prostaglandin E2 by low-dose aspirin: implications for adenocarcinoma metastasis. Cancer Prev Res. 2016;9:855–865. doi:10.1158/1940-6207.CAPR-16-0094 27. Tacconelli S, Contursi A, Falcone L, et al. Characterization of cyclooxygenase-2 acetylation and prostanoid inhibition by aspirin in cellular systems. Biochem Pharmacol. 2020;178:114094. doi:10.1016/j.bcp.2020.114094 28. Pepine CJ, Gurbel PA. Cardiovascular safety of NSAIDs: additional insights after PRECISION and point of view. Clin Cardiol. 2017;40:1352–1356. doi:10.1002/clc.22814 29. Bliden KP, Singla A, Gesheff MG, et al. Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin. Thromb Haemost. 2014;112:323. doi:10.1160/TH14-01-0094 30. Gurbel PA, Bliden KP, Tantry US. Defining platelet response to acetylsalicylic acid: the relation between inhibition of serum thromboxane B2 and agonist-induced platelet aggregation. J Thromb Thrombolysis. 2021;51:260–264. doi:10.1007/s11239-020-02334-x 31. Chaudhary R, Bliden KP, Garg J, et al. Statin therapy and inflammation in patients with diabetes treated with high dose aspirin. J Diabetes Complications. 2016;30:1365–1370. doi:10.1016/j.jdiacomp.2016.05.002 32. Eikelboom JW, Hirsh J, Weitz JI, et al. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation. 2002;105:1650–1655. doi:10.1161/01.CIR.0000013777.21160.07 33. Eikelboom JW, Hankey GJ, Thom J, et al. Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk. Circulation. 2008;118:1705–1712. doi:10.1161/CIRCULATIONAHA.108.768283 34. Rocca B, Buck G, Petrucci G, et al. ; The ASCEND Study Collaborative Group. Thromboxane metabolite excretion is associated with serious vascular events in diabetes mellitus: a sub-study of the ASCEND trial. Eur Heart J. 2020;41(2): ehaa946.2926 . doi:10.1093/ehjci/ehaa946.2926 35. Ortiz-Muñoz G, Mallavia B, Bins A, et al. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014;124:2625–2634. doi:10.1182/blood-2014-03-562876 36. Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, et al. 15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation. J Exp Med. 2004;200:69–78. doi:10.1084/jem.20040566 37. Nascimento-Silva V, Arruda MA, Barja-Fidalgo C, Fierro IM. Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism. Thromb Haemost. 2007;97:88–98. doi:10.1160/TH06-06-0315 38. Taubert D, Berkels R, Grosser N, et al. Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action. Br J Pharmacol. 2004;143(1):159–165. doi:10.1038/sj.bjp.0705907 39. Sun YP, Oh SF, Uddin J, et al. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007;282:9323–9334. doi:10.1074/jbc.M609212200 40. Eickmeier O, Seki H, Haworth O, et al. Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. Mucosal Immunol. 2013;6:256–266. doi:10.1038/mi.2012.66 41. Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 1998;396:77–80. doi:10.1038/23948 42. Frantz B, O’Neill EA. The effect of sodium salicylate and aspirin on NF-kappa B. Science. 1995;270:2017–2019. doi:10.1126/science.270.5244.2017 43. Glatthaar-Saalmüller B, Mair KH, Saalmüller A. Antiviral activity of aspirin against RNA viruses of the respiratory tract-an in vitro study. Influenza Other Respir Viruses. 2017;11:85–92. doi:10.1111/irv.12421 44. Undas A, Brummel-Ziedins KE, Mann KG. Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions. Blood. 2007;109:2285–2292. doi:10.1182/blood-2006-01-010645 45. Undas A, Brummel-Ziedins K-E, Mann KG. Why does aspirin decrease the risk of venous thromboembolism? On old and novel antithrombotic effects of acetyl salicylic acid. J Thromb and Haemost. 2014;12:1776–1787. doi:10.1111/jth.12728 46. Tarantino E, Amadio P, Squellerio I, et al. Role of thromboxane-dependent platelet activation in venous thrombosis: aspirin effects in mouse model. Pharmacol Res. 2016;107:415–425. doi:10.1016/j.phrs.2016.04.001 47. Bailey MA, Aggarwal R, Bridge KI, et al. Aspirin therapy is associated with less compact fibrin networks and enhanced fibrinolysis in patients with abdominal aortic aneurysm. Thromb Haemost. 2015;13:795–801. doi:10.1111/jth.12872 48. Tehrani S, Antovic A, Mobarrez F, et al. High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes. Diabetes Care. 2012;35:404–408. doi:10.2337/dc11-1302 49. Smith WL. The eicosanoids and their biochemical mechanisms of action. Biochem J. 1989;259:315–324. doi:10.1042/bj2590315 50. Wang J, Zhang CJ, Zhang J, et al. Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP). Sci Rep. 2015;5:7896. doi:10.1038/srep07896 51. Choudhary C, Kumar C, Gnad F, et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009;325:834–840. doi:10.1126/science.1175371 52. Lapponi MJ, Carestia A, Landoni VI, et al. Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther. 2013;345:430–437. doi:10.1124/jpet.112.202879 53. Chen CM, Tung YT, Wei CH, et al. Anti-inflammatory and reactive oxygen species suppression through aspirin pretreatment to treat hyperoxia-induced acute lung injury in NF-κB-luciferase inducible transgenic mice. Antioxidants. 2020;9:429. doi:10.3390/antiox9050429 54. Huang RT, Dietsch E. Anti-influenza viral activity of aspirin in cell culture. N Engl J Med. 1988;319:797. 55. Mazur I, Wurzer WJ, Ehrhardt C, Al ET. Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell Microbiol. 2007;9:1683–1694. doi:10.1111/j.1462-5822.2007.00902.x 56. Zarbock A, Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest. 2006;116:3211–3219. doi:10.1172/JCI29499 57. Chen CM, Lu HC, Tung YT, Chen W. Antiplatelet therapy for acute respiratory distress syndrome. Biomedicines. 2020;8:230. doi:10.3390/biomedicines8070230 58. Toner P, McAuley DF, Shyamsundar M. Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome. Crit Care. 2015;19:374. doi:10.1186/s13054-015-1091-6 59. Panka BA, de Grooth HJ, Spoelstra-de Man AM, et al. Prevention or treatment of ardss with aspirin: a review of preclinical models and meta-analysis of clinical studies. Shock. 2017;47:13–21. doi:10.1097/SHK.0000000000000745 60. Erlich JM, Talmor DS, Cartin-Ceba R, et al. Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study. Chest. 2011;139:289–295. doi:10.1378/chest.10-0891 61. Eisen DP, Reid D, McBryde ES. Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis. Crit Care Med. 2012;40:1761–1767. doi:10.1097/CCM.0b013e318246b9df 62. Sossdorf M, Otto GP, Boettel J, et al. Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients. Crit Care. 2013;17:402. doi:10.1186/cc11886 63. Boyle AJ, Di Gangi S, Hamid UI, et al. Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis. Crit Care. 2015;19:1–8. doi:10.1186/s13054-015-0846-4 64. Kor DJ, Erlich J, Gong MN, et al. Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients. Crit Care Med. 2011;39:2393–2400. doi:10.1097/CCM.0b013e318225757f 65. Liang H, Ding X, Li H, Li L, Sun T. Association between prior aspirin use and acute respiratory distress syndrome incidence in at-risk patients: a systematic review and meta-analysis. Front Pharmacol. 2020;19(11):738. doi:10.3389/fphar.2020.00738 66. Harr JN, Moore EE, Johnson J, et al. Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients. Crit Care Med. 2013;41:399–404. doi:10.1097/CCM.0b013e31826ab38b 67. O’Neal HR, Koyama T, Koehler EA, et al. Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2011;39:1343–1350. doi:10.1097/CCM.0b013e3182120992 68. Chen W, Janz DR, Bastarache JA, et al. Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis. Crit Care Med. 2015;43:801–807. doi:10.1097/CCM.0000000000000789 69. Trauer J, Muhi S, McBryde ES, et al. Quantifying the effects of prior acetyl-salicylic acid on sepsis-related deaths: an individual patient data meta-analysis using propensity matching. Crit Care Med. 2017;45:1871–1879. doi:10.1097/CCM.0000000000002654 70. Kiers D, van der Heijden WA, Al ET. A randomized trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia. Thromb Haemost. 2017;117:1798–1807. doi:10.1160/TH16-10-0799 71. Gurbel PA, Bliden KP, Walia N, et al. Is low dose aspirin effective in reducing in-hospital clinical outcomes in patients with COVID-19? J Am Coll Cardiol. 2021;77:3083. doi:10.1016/S0735-1097(21)04438-7 72. Gurbel PA, Bliden KP, Tantry US. Defining platelet response to acetylsalicylic acid: the relation between inhibition of serum thromboxane B2 and agonist-induced platelet aggregation. J Thromb Thrombolysis. 2021;51:260–264. 73. Chow JH, Khanna AK, Kethireddy S, et al. Aspirin use is associated with decreased mechanical ventilation, intensive care unit admission, and in-hospital mortality in hospitalized patients with coronavirus disease 2019. Anesth Analg. 2021;132:930–941. doi:10.1213/ANE.0000000000005292 74. Osborne TF, Veigulis ZP, Arreola DM, et al. Association of mortality and aspirin prescription for COVID-19 patients at the Veterans Health Administration. PLoS One. 2021;16:e0246825. doi:10.1371/journal.pone.0246825 75. Meizlish ML, Goshua G, Liu Y, et al. Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: a propensity score-matched analysis. Am J Hematol. 2021;96:471–479. doi:10.1002/ajh.26102 76. Merzon E, Green I, Vinker S, et al. The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection. FEBS J. 2021;288(17):5179–5189. doi:10.1111/febs.15784 77. Liu Q, Huang N, Li A, et al. Effect of low-dose aspirin on mortality and viral duration of the hospitalized adults with COVID-19. Medicine. 2021;100:e24544. doi:10.1097/MD.0000000000024544 78. Haji Aghajani M, Moradi O, Amini H, et al. Decreased in-hospital mortality associated with aspirin administration in hospitalized patients due to severe COVID-19. J Med Virol. 2021;93(9):5390–5395. doi:10.1002/jmv.27053 79. Sahai A, Bhandari R, Godwin M, et al. Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19. Vasc Med;2021. 1358863X2110127. doi:10.1177/1358863X211012754 80. Yuan S, Chen P, Li H, et al. Mortality and pre-hospitalization use of low-dose aspirin in COVID-19 patients with coronary artery disease. J Cell Mol Med. 2021;25:1263–1273. doi:10.1111/jcmm.16198 81. Reese JT, Coleman B, Chan L, et al. Cyclooxygenase inhibitor use is associated with increased COVID-19 severity. medRxiv. 2021;1:548. 82. Martha JW, Pranata R, Lim MA, et al. Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19 - a systematic review and meta-analysis of adjusted effect estimates. Int J Infect Dis. 2021;1:00417. 83. Schrör K. Acetylsalicylic Acid. 2nd . ed, Schrör KK. Weinheim, Germany:Wiley-VCH Verlag GmbH & Co; 2016 84. Scheuch G, Canisius S, Nocker K, et al. Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients. Emerg Microbes Infect. 2018;7:21. doi:10.1038/s41426-018-0023-3 85. Soleti A, Zuccari G, Omini C, et al. Aspirin inhalation treatment for COPD patients: preliminary studies on PK and inflammatory biomarkers. Eur Respiratory J. 2011;38(Supple55;p825):487. 86. Droebner K, Haasbach E, Dudek SE, et al. Pharmacodynamics, pharmacokinetics, and antiviral activity of BAY 81-8781, a novel NF-κB inhibiting anti-influenza drug. Front Microbiol. 2017;8:2130. doi:10.3389/fmicb.2017.02130 87. Kanani K, Gatoulis SC, Voelker M. Influence of differing analgesic formulations of aspirin on pharmacokinetic parameters. Pharmaceutics. 2015;7:188–198. doi:10.3390/pharmaceutics7030188 88. Muller C, Karl N, Ziebuhr J, Pleschka SDD. L-lysine acetylsalicylate + glycine impairs coronavirus replication. J Antivir Antiretrovir. 2016;4:142–150. 89. Gurbel PA, Bliden KP, Chaudhary R, Tantry US. First in-human experience with inhaled acetylsalicylic acid for immediate platelet inhibition: comparison with chewed and swallowed acetylsalicylic acid. Circulation. 2020;142:1305–1307. doi:10.1161/CIRCULATIONAHA.120.047477 This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License .By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms .

  • Where is Instrumentation Laboratories's headquarters?

    Instrumentation Laboratories's headquarters is located at Via le Monza 338 , Milan.

  • What is Instrumentation Laboratories's latest funding round?

    Instrumentation Laboratories's latest funding round is Acquired.

  • Who are the investors of Instrumentation Laboratories?

    Investors of Instrumentation Laboratories include CVC Capital Partners.

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