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Glycoform

glycoform.co.uk

Founded Year

2002

Stage

Series B | Alive

Total Raised

$1.48M

Last Raised

$1.48M | 19 yrs ago

About Glycoform

GlycoForm is a biotechnology company with a core expertise and intellectual property in sugar chemistry and protein glycosylation.

Headquarters Location

Unit 44C Milton Park

Oxfordshire, England, OX14 4RU,

United Kingdom

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Latest Glycoform News

Bristol Myers Squibb : Researchers at Bristol-Myers Squibb Report New Data on Chromatography (Heterogeneous glycoform separation by process chromatography: I Monomer...

Jul 23, 2015

(You can enter multiple email addresses separated by commas) Message : *Required fields Researchers at Bristol-Myers Squibb Report New Data on Chromatography (Heterogeneous glycoform separation by process chromatography: I Monomer purification and characterization) By a News Reporter-Staff News Editor at Science Letter -- Current study results on Science have been published. According to news reporting out of Hopewell, New Jersey , by NewsRx editors, research stated, "Fc fusion proteins with high and low sialylation were purified and separated by preparative ion-exchange and hydrophobic interaction chromatography. Heterogeneity in sialylation and glycosylation led to variation in surface charge and hydrophobicity, and resulted in multiple distinct glycoform populations in response to various purification conditions. " Our news journalists obtained a quote from the research from Bristol-Myers Squibb , "Monomer with high sialic acid content has higher surface charge and adsorbs stronger to ion-exchange resin, while the less sialylated monomer interacts more favorably with hydrophobic resin. Extensive biophysical characterization was carried out for purified monomers at different level of sialylation. In general, different monomeric glycoforms have different surface charge and hydrophobicity, different thermal stability, and different aggregation propensity. The surface charge corresponds well with sialic acid content, as evidenced by electrophoresis, N-link domain analysis, and zeta potential results. The sialylation also contributes to minor modification of protein size, molecular mass and tertiary structure. Notably, fluorescence emission spectra and thermal transition became less distinguishable when the monomers containing low and high sialic acid were prepared in high ionic strength solution. Such finding reiterates the fact that the electrostatic forces, which are largely dependent on sialic acid content of protein, plays a dominant role in many intra- and inter-molecular interactions. " According to the news editors, the research concluded: "Overall, the characterization data agreed well with separation behaviors and provided valuable insight to control of glycoform profile in purification process. " For more information on this research see: Heterogeneous glycoform separation by process chromatography: I Monomer purification and characterization. Journal of Chromatography A

Glycoform Frequently Asked Questions (FAQ)

  • When was Glycoform founded?

    Glycoform was founded in 2002.

  • Where is Glycoform's headquarters?

    Glycoform's headquarters is located at Unit 44C, Oxfordshire.

  • What is Glycoform's latest funding round?

    Glycoform's latest funding round is Series B.

  • How much did Glycoform raise?

    Glycoform raised a total of $1.48M.

  • Who are the investors of Glycoform?

    Investors of Glycoform include IP Group, East Hill Management Co., Oxford University Innovation and Spark Ventures.

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