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MOBILE & TELECOMMUNICATIONS | Mobile Software & Services / Payments
gli.ph

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Stage

Seed - III | Alive

Total Raised

$290K

Last Raised

$70K | 8 yrs ago

About Gliph

Gliph is a secure messaging application that lets people anonymously transfer Bitcoin payments. It works with existing Bitcoin wallets Coinbase, BIPS, and Blockchain.

Gliph Headquarter Location

Portland, Oregon,

United States

Latest Gliph News

Identifying specificity groups in the T cell receptor repertoire

Jun 21, 2017

Identifying specificity groups in the T cell receptor repertoire 17:25 EDT 21 Jun 2017 | Nature Publishing Home » Topics » Myc the protein encoded by the MYC gene that activates the cell cycle » Latest News » Identifying specificity groups in the T cell receptor repertoire T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual. Here we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using a panel of peptide and major histocompatibility complex (pMHC)-tetramer-sorted cells and structural data. From this analysis we developed an algorithm that we term GLIPH (grouping of lymphocyte interactions by paratope hotspots) to cluster TCRs with a high probability of sharing specificity owing to both conserved motifs and global similarity of complementarity-determining region 3 (CDR3) sequences. We show that GLIPH can reliably group TCRs of common specificity from different donors, and that conserved CDR3 motifs help to define the TCR clusters that are often contact points with the antigenic peptides. As an independent validation, we analysed 5,711 TCRβ chain sequences from reactive CD4 T cells from 22 individuals with latent Mycobacterium tuberculosis infection. We found 141 TCR specificity groups, including 16 distinct groups containing TCRs from multiple individuals. These TCR groups typically shared HLA alleles, allowing prediction of the likely HLA restriction, and a large number of M. tuberculosis T cell epitopes enabled us to identify pMHC ligands for all five of the groups tested. Mutagenesis and de novo TCR design confirmed that the GLIPH-identified motifs were critical and sufficient for shared-antigen recognition. Thus the GLIPH algorithm can analyse large numbers of TCR sequences and define TCR specificity groups shared by TCRs and individuals, which should greatly accelerate the analysis of T cell responses and expedite the identification of specific ligands. Related Biotechnology, Pharmaceutical and Healthcare News

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Expert Collections containing Gliph

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Gliph is included in 2 Expert Collections, including Blockchain.

B

Blockchain

3,282 items

Companies and startups in this collection leverage blockchain technology for crypto investing and trading, decentralized finance (DeFi), NFTs, and more.

F

Fintech

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US-based companies

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