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fractyl.com

Founded Year

2010

Stage

Debt | Alive

Total Raised

$300.42M

Last Raised

$20.08M | 7 mos ago

About Fractyl Health

Fractyl develops Revita DMR, a same-day, minimally-invasive procedure to treat two highly prevalent metabolic diseases: type 2 diabetes and NAFLD/NASH. The Revita DMR procedure harnesses current insights from bariatric science to address a root cause of insulin resistance in the duodenum. Fractyl's approach aims to improve the health of patients with metabolic diseases with device-based interventions for patients and healthcare systems.

Fractyl Health Headquarters Location

17 Hartwell Ave

Lexington, Massachusetts, 02421,

United States

781-902-8800

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Expert Collections containing Fractyl Health

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Fractyl Health is included in 3 Expert Collections, including Medical Devices.

M

Medical Devices

9,064 items

Companies developing medical devices (per the IMDRF's definition of "medical device"). Includes software, lab-developed tests (LDTs), and combination products. *Columns updated as regularly as possible.

D

Diabetes

1,750 items

H

Health IT

7,900 items

Fractyl Health Patents

Fractyl Health has filed 35 patents.

The 3 most popular patent topics include:

  • Diabetes
  • Digestive system
  • Digestive system surgery
patents chart

Application Date

Grant Date

Title

Related Topics

Status

3/30/2015

2/15/2022

Diabetes, Digestive system surgery, Digestive system, Drug delivery devices, Rare diseases

Grant

Application Date

3/30/2015

Grant Date

2/15/2022

Title

Related Topics

Diabetes, Digestive system surgery, Digestive system, Drug delivery devices, Rare diseases

Status

Grant

Latest Fractyl Health News

PCOS in Moms Tied to Health Problems in Kids

Jul 19, 2022

Jake Remaly July 18, 2022 Children whose mothers have polycystic ovary syndrome (PCOS) have increased rates of hospitalization for various conditions, including asthma, pneumonia, and ear infection, a study of more than 1 million children shows. The associations were not particularly strong, according to the researchers. But they raise questions about the reasons for the increased risk and whether interventions like diet, exercise, or medications could lead to healthier outcomes for children whose mothers have PCOS. “The findings suggest that maternal PCOS may have a negative impact on offspring development, enough to lead to a measurable increase in the risk of childhood hospitalization,” study coauthor Nathalie Auger, MD, associate professor of epidemiology at University of Montreal, Montreal, Quebec, Canada, and colleagues reported in Human Reproduction. “They are minor differences, just enough that we can statistically identify them. They’re not something where everyone should be worrying at this point,” Auger told Medscape Medical News. Still, some of the hospitalizations, such as those related to infection or allergy, potentially could be prevented with earlier ambulatory care, so some degree of greater awareness among parents and clinicians may be warranted, she said. 13 Years of Follow Up PCOS — a reproductive disorder characterized by irregular periods, increased male hormones, and metabolic complications — affects some 10% of women. People with the condition are at increased risk for obesity , type 2 diabetes , and cardiovascular disease. Although prior research has shown that maternal PCOS may be associated with higher body mass index and attention deficit disorder in children, data on long-term childhood health outcomes have been limited, Auger’s group noted. To examine illness in children exposed to maternal PCOS, the investigators analyzed hospitalization rates for nearly 1.04 million children in Quebec between 2006 and 2020; 7160 of the children had mothers with PCOS. In all, 275,354 children were hospitalized during 13 years of follow up, including 2314 whose mothers had PCOS. Children exposed to PCOS were hospitalized at a rate of 68.9 per 1000 person-years — roughly 50% more often than the rate of 45.3 per 1000 person-years for children not exposed to maternal PCOS. In an analysis that adjusted for maternal characteristics, childhood hospitalization for any reason was 1.32 times more likely for children exposed to maternal PCOS. Hospitalizations linked to infectious diseases — such as for bronchitis , bronchiolitis , pneumonia, nephritis, otitis media , or meningitis — were 1.31 times more likely among children exposed to PCOS. Allergy-related hospitalizations, such as for allergic asthma and anaphylaxis , were 1.47 times more likely, according to the researchers. Metabolic hospitalizations were 1.59 times more likely. For gastrointestinal hospitalizations, the hazard ratio was 1.72. For central nervous system hospitalizations, it was 1.74. The associations were stronger in earlier childhood, and results were similar for boys and girls, the investigators reported. Hospitalizations for cardiovascular disease, musculoskeletal conditions, or malignancy were not increased. ‘Surprising’ Links “The findings are surprising in that some of the conditions that they showed increased risk for, like asthma and some infections, are not conditions that we think of as being typically associated with PCOS,” said Andrea E. Dunaif, MD, chief of the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes and Bone Disease at Mount Sinai Health System, New York City, who was not part of the study team. Earlier studies of offspring of women with PCOS have suggested that children may be at increased risk for insulin resistance and obesity. Differences in genetics, intrauterine environments, patterns of healthcare use by women with PCOS, and behavioral factors like diet and how children are raised are variables that potentially could have contributed to the different hospitalization rates among children exposed to maternal PCOS, Auger said. “Everything is interconnected,” she said. The study was supported by a grant from the Canadian Institutes of Health Research. Auger has received a career award from the Fonds de Recherche du Québec-Santé. Dunaif has consulted for Novo Nordisk and Fractyl Laboratories (now Fractyl Health). Hum Reprod. Published online July 13, 2022. Full text.

Fractyl Health Web Traffic

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  • When was Fractyl Health founded?

    Fractyl Health was founded in 2010.

  • Where is Fractyl Health's headquarters?

    Fractyl Health's headquarters is located at 17 Hartwell Ave, Lexington.

  • What is Fractyl Health's latest funding round?

    Fractyl Health's latest funding round is Debt.

  • How much did Fractyl Health raise?

    Fractyl Health raised a total of $300.42M.

  • Who are the investors of Fractyl Health?

    Investors of Fractyl Health include Population Health Partners, M28 Capital, Maverick Ventures, General Catalyst, Bessemer Venture Partners and 16 more.

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