Zaib Shaikh, Canada’s Consul General to Los Angeles, hosted the country’s annual Canada at the Oscars soiree Thursday at his official residence in Hancock Park. The event was the first stop of the night for many Oscar-nominated Canadians including “Women Talking’s” Sarah Polley , Sheila McCarthy and Kate Hallet. Polley was headed to the Macro party . Other attendees were going to the Oscar Wilde Awards or the South Asian Excellence Pre-Oscars Celebration. Also in attendance were “Turning Red’s” Domee Shi, who landed an Oscar for best animated feature, Brendan Fraser and “The Whale” prosthetics makeup designer Adrien Morot. The night celebrated Canadian Oscar winners and nominees, past and present. Last year’s nominated makeup artist for “Dune,” Donald Mowat, spoke with Variety about his upcoming work with frequent collaborator Jake Gyllenhaal. On the TV series, “Presumed Innocent,” Mowat said, “He gets to be a heartbroken lawyer with a chiseled body and is married to Ruth Negga. It’s the easiest job I’ve done.”
Their other collaboration, “The Covenant,” directed by Guy Ritchie, is headed to theaters in April. The film follows Gyllenhaal’s character as Sergeant John on his last tour of duty in Afghanistan. Dar Salim also stars. “It is an anti-war movie. It’s pro-American about Americans who do something good. He looks gorgeous in it,” Mowat teased. Mowat did say he has finished work on the “Dune 2” sequel due out later this year. He kept those makeup secrets under lock and key. But he did offer something. “Florence Pugh and Zendaya… gorgeous,” he said as he put his fingers to his lips and blew a chef’s kiss. During his toast, Shaikh celebrated the boost to Canadian filmmaking from productions. He said, “The world over is bringing millions of dollars into the economy not only on behalf of Canada but here as part of the Hollywood storytelling machine. That’s over $10 billion to bring brought to the economy of Canada. “
As the night came to a close and guests made their way home, a poutine truck awaited them in the driveway. Polley expressed her love for the Candian dish that consists of French fries topped with cheese curds and gravy. Hallet and co-star Kira Guloien made sure to stop for some. And Polley deserves a prize for best footwear of the night. Under her gown, she was rocking Dr. Martens boots. “They’re so comfortable,” she said before saying adieu and making her way to the next event. Be on the lookout — as Polley did hint at what shoes she will be wearing on Oscars Sunday. Read More About:

Canada Celebrates Oscars: Poutine, Sarah Polley Rocks Dr. Martens, and Talking Jake Gyllenhaal’s Upcoming Projects

By Hannah Flynn on March 5, 2023 — Fact checked by Ferdinand Lali, Ph.D.
Scientists are trying to see if supplements can have an impact on brain aging. Extreme Media/Getty Images
Aging can cause cognitive decline due to changes that happen in our brain cells; however, it is not clear how much of this is intrinsic or due to diseases such as Alzheimer’s. In order to improve energy metabolism in the brain, a group of scientists looked at the effect of supplementing a group of adults with a form of vitamin B3. The researchers found that the supplement nicotinamide riboside was converted into a molecule involved in energy metabolism in neurons. They also observed a small but significant decrease in the levels of amyloid beta protein in neurons, following supplementation. Age isn’t just a number, and aging mechanisms affect us at a cellular level. The reason why some people age faster than others has been the focus of much recent research. One condition for which age is a risk factor is dementia. About one-third of people who are over the age of 85 have some form of
. As humans are living longer, the number of people with dementia in the population is also growing, and the
Despite this high prevalence, the mechanisms and risk factors underlying dementia are poorly understood. The prevailing understanding is that Alzheimer’s disease is thought to be underpinned by the presence of clumps of certain forms of a protein called beta-amyloid between neurons, or nerve cells, in the brain. This is thought to affect their ability to signal, causing the cognitive decline seen in individuals with the condition. However, it is important to note there is still significant debate over this mechanism, and how much of an impact it has on the development of Alzheimer’s disease, as well as its suitability as a potential target for treatment. One theory is that the decline in cognition observed in people with Alzheimer’s disease is due to the disruption of typical energy production and metabolism in the brain. A recent paper published in Aging Cell on the subject explores whether vitamin B could help offset this disruption. The brain is hugely energy dependent, and uses up to 20% of oxygen and therefore calories, of those used by the whole body, despite making up just 2% of its mass. This energy metabolism is understood to be disrupted in the brains of people with Alzheimer’s disease. One way this can be disrupted is when nerve cells in the brain become insulin resistant. Insulin resistance means that the cells do not take up glucose for energy as they should. When this occurs in the brain energy metabolism, signalling and immune response functions are all affected negatively. This can occur in individuals who have
, which is characterised by insulin resistance, and there is a correlation between the condition and Alzheimer’s disease, though it is unclear why. Dr. Kellie Middleton , orthopaedic surgeon at Northside Hospital, Atlanta, Georgia, who was not involved in the study, explained to Medical News Today:
“Neurodegeneration is a term used to describe the progressive loss of nerve cells in the brain and spinal cord, leading to problems with memory, cognition, movement, and other neurological functions. It can be caused by genetic or [underlying medical conditions including] aging, diabetes, stroke, Parkinson’s disease, Alzheimer’s disease, or traumatic brain injury.”
“Biochemical pathways are known to be associated with various forms of neurodegeneration, and research into these pathways is ongoing. For example, studies have highlighted connections between imbalances in energy metabolism, oxidative stress, inflammation, and mitochondrial dysfunction with the development of neurological diseases,” she continued. If the brain cells can’t produce the energy they need to be able to function, then they can’t signal, and if nerve cells in the brain can’t signal effectively then cognition will be affected. Whether this is a cause of the disease or a symptom is unclear, said Dr. Christopher Martens , director of the Delaware Center for Cognitive Aging Research, and lead author of the current study. “One of the main challenges with Alzheimer’s disease is the disruption of energy metabolism in the brain, which may actually contribute to the development of the disease.”
— Dr. Christopher Martens
Dr. Martens and his team looked at the role of a particular molecule involved in energy metabolism, called nicotinamide adenine dinucleotide, or NAD+. “NAD+ is essential for cells to create energy and there is strong evidence from animal studies that aging and metabolic dysfunction results in a depletion of NAD+ within cells. Therefore, there is strong rationale that replenishing the NAD+ within the brain could have a positive effect on brain function,” he explained to MNT. In order to do this a cohort of 10 adults were given a form of vitamin B3 called nicotinamide riboside as a supplement, as this molecule is a precursor for NAD+. This means that the body converts it into NAD+. A group of 12 other adults received a placebo. Neither group knew whether they were receiving the supplement or a placebo. In order to measure whether or not taking 500mg of the supplement twice a day for six weeks actually increased NAD+ in neurons, researchers measured the NAD+ in extracellular vesicles that are present in the neurons and end up in the blood. They extracted these from blood samples and found a small, but significant difference. These results were previously published in 2018 in
. In addition to this finding, the team have now published data showing that changes in levels of NAD+ and its precursors were correlated with changes in the presence of insulin-signalling proteins and molecules involved in inflammation, also thought to play a role in the development of Alzheimer’s and dementia. While decreases in the tau and amyloid proteins, thought to be involved in the development of Alzheimer’s disease, were not significant when comparing all supplemented participants to placebo, a small but significant change was observed in the levels of these marker proteins in the extracellular vesicles of a sub-set of the supplemented participants who responded. Still, it is unclear if the supplement had crossed the blood-brain barrier and that these changes took place in brain cells. “We don’t have definitive proof that the supplement itself crosses the blood-brain barrier, especially not from our data. What we do know is that taking the supplement results in an increase in NAD+ within tiny vesicles that likely originated in the brain and other neural tissue,” Dr. Martens told MNT. “This is one of the big challenges in the field [d]etermining whether the compound can reach its intended target. [A]lthough we do not have direct evidence, the results of our study suggest that it is having an effect on the brain and also changing the metabolism of molecular pathways known to be involved in Alzheimer’s disease,” he added. This was the next step for the team said Dr. Martens. “This is something we are actively testing now in my laboratory in a follow-up trial in older adults with mild cognitive impairment, but first we wanted to understand whether we could detect an increase in NAD+ in brain tissue after taking the supplement,” he said. “We did this using small vesicles found in the blood that we are quite confident originated in neurons. What’s really interesting is that we also found changes in more established markers of Alzheimer’s disease (e.g., amyloid beta) after taking the supplement,” he added. “While there are some promising therapeutic strategies being explored for neurodegenerative diseases, more research is needed to fully understand their potential benefit.”
— Dr. Kellie Middleton

Alzheimer's: Vitamin B supplementation could slow aging of neurons

A Guide for Immortal Design: Dr. Martens
Feb 14, 2023
Fashion cycles are often analyzed within two notions: secular trends that span decades, centuries even, and short cycles that only last several months to a year. Dr. Martens sits outside of this. The brand transcends trends, which usually function as a governing modus operandi. Read more at 032c . SHARE

A Guide for Immortal Design: Dr. Martens

Bloomberg
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Navis Weighing Stake Sale of Dr. Martens’s Leather Supplier, Sources Say

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Swarovski delivers a diverse portfolio of quality, craftsmanship, and creativity. Founded in 1895 in Austria, Swarovski designs, manufactures and markets high-quality crystals, genuine gemstones and created stones as well as finished products such as jewelry, accessories and lighting.

Gernot Langes-Swarovski & Co.

The It List : Dr. Martens , Swarovski team up for sparkling collaboration Back to video

The It List: Dr. Martens, Swarovski team up for sparkling collaboration

Depop allows creative individuals, independent retailers, and brands to sell goods through a mobile device within a like-minded community. Sellers can take a photo of the product and upload it to their profile page, enter a description, including price, location, and delivery details before making it publicly available. Social features enable users to follow each other, post comments, plus share their activity to other social networks. On June 2, 2021, Depop was acquired by Etsy at a valuation of $1.63B.

Depop

Supreme offers eBay tools to help sellers improve the shopping experience for their customers.

Supreme

Goodhood is a multi brand retailer that sells menswear, womenswear, and cosmetics. It is based in London, England.

Goodhood

Cath Kidston

Levi Strauss

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Dr Martens is a global brand with a rich and diverse heritage and a contemporary relevance. Headquartered in Northants on the site of the original factory, it is sold in 63 countries, principally in the US, Asia, Europe and the UK. The company's deep-rooted links with the working class, music, subcultures and self-expression have kept the brand at the forefront of youth culture for over 50 years.

Name	Work History	Title	Status
Kenny Wilson	Cath Kidston, and Levi Strauss	Chief Executive Officer	Current
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Name	Kenny Wilson	Subscribe to see more	Subscribe to see more	Subscribe to see more	Subscribe to see more
Work History	Cath Kidston, and Levi Strauss	Subscribe to see more	Subscribe to see more	Subscribe to see more	Subscribe to see more
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