Colorectal cancer risk stratification on histological slides based on survival curves predicted by deep learning

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Ukraine’s foreign allies have pledged to the Ukrainian war efforts dozens of armored engineering vehicles: American-made M-88s; Challenger recovery vehicles from the United Kingdom; Bergepanzers, Wisents and Dachs from Germany; and even some very rare Norwegian NM189s , Swedish Bgbv 90s and Leopard 2Rs from Finland. But for all that, the most common AEV in Ukrainian service is an ex-Soviet classic: the IMR-2. Basically, an old T-72 tank chassis with a crane in the place of its turret plus a hull-mounted dozer blade. The IMR-2s are everywhere along the 600-mile front line in Ukraine: unsticking vehicles stuck in the mud, towing abandoned Russian tanks from rivers and using their dozer blades to clear paths through minefields. The two-person, 47-ton IMR-2s with their 840-horsepower diesel engines are anything but sophisticated. They’re underpowered and lightly protected compared to the latest Western engineering vehicles. But they’re reliable ... and available. And that counts for a lot. It actually is an accident of history that the Ukrainian army, marine corps, separate air-assault forces and other military branches have so many IMR-2s. Yes, the Ukrainians in the first 18 months of Russia’s wider war on Ukraine have captured from Russian forces no fewer than a dozen IMR-2s. But most of Ukraine’s IMR-2s are from Ukrainian stocks. As social media user B-AREV explained in a recent post: when the Soviet Union collapsed in 1991, its army left behind in Ukraine scores of IMR-2s. In the 2010s, there still were several dozen decades-old IMR-2s in storage at the 20th Arsenal of the Engineer Troops in Kyiv Oblast. The IMR-2s were among the more common vehicles at the storage site, greatly outnumbering UR-77 mineclearing vehicles, BRM-2 mineclearers and BAT-2 forest-clearing vehicles. That makes sense. Where a UR-77 with its explosive line-charge is good for pretty much one thing—clearing a minefield—an IMR-2 can do lots of things. Assist with construction. Recover immobilized vehicles. Clear mines with its dozer blade. Even help to fill enemy trenches and breach enemy berms. So it also makes sense that, when Russian forces first invaded Ukraine in early 2014 and the Ukrainian armed forces mobilized for what would be a very long war, technicians began reactivating many of the IMR-2s at the 20th Arsenal. Between the IMR-2s that already were in service, the IMR-2s the Ukrainians recovered from open storage and the IMR-2s Russian forces have abandoned in Ukraine, Kyiv’s brigades might have more than 50 of the old—but reliable and versatile—engineering vehicles. Think of them as the very opposite of what might be among the rarest and most specialized of Ukraine’s engineering vehicles: the BTM-3 trench-diggers. Follow me on  Twitter . Check out my  website  or some of my other work  here . Send me a secure  tip .

The Collapsing Soviet Army Left Behind Dozens Of IMR-2 Engineering Vehicles. The Ukrainian Army Eagerly Snatched Them Up.

Milwaukee Diaper Mission Fights ‘Period Poverty’
Providing free diapers and menstrual products to poor families in the county. //end headline wrapper ?>
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Nicole Dachs (left) and Jamie Robarge, who are volunteers at the Milwaukee Diaper Mission, stand in front of a wall of 15,000 period products they were able to raise at their second annual Period Party. In a 5,000-square-foot warehouse in Franklin, thousands of boxed diapers and menstrual products sat ready to be distributed, free of charge, to those in need in Milwaukee. On May 31, the Milwaukee Diaper Mission reached a milestone of 300,000 period products donated to women in need. The celebration included the making of 188 period kits to be distributed to food pantries across Milwaukee. Those who joined the celebration included Deputy Commissioner of Community Health Erica Olivier , Milwaukee County Executive David Crowley and the Friedens Food Pantries , the Diaper Mission’s largest period product and diaper distributor. In 2020, the executive director of the Milwaukee Diaper Mission, Meagan Johnson , learned that many families were burdened with the high cost of diapers. She also discovered there was no basic needs bank in Milwaukee. She decided to open the Milwaukee Diaper Mission that year. Soon after the opening of the Diaper Mission, the organization pivoted to also supplying period products. Serving the community
“We recognized that there was no resource in our community providing menstruators with period kits on a monthly basis,” Johnson said. Meagan Johnson (center),executive director of the Milwaukee Diaper Mission, receives a certificate of recognition from Deputy Commissioner of Community Health Erica Olivier (right). Also pictured is Milwaukee County Executive David Crowley. According to the American Medical Women’s Association,  “period poverty”  is a term used to describe the widespread issue of individuals facing financial constraints that prevent them from accessing essential menstrual products such as pads, tampons or liners to effectively manage menstrual bleeding. Recent studies  show that about 1 in 3 people who menstruate in the United States are unable to afford essential period products monthly. This financial barrier leads to chronic school absenteeism, limited job opportunities and the potential for significant medical concerns. A continuing fight
The fight to end period poverty has grown significantly in Milwaukee since the Diaper Mission took it on. Joining the mission are many dedicated volunteers. Jamie Robarge and Nicole Dachs became friends through their time at the Diaper Mission. Both had their own experiences with period poverty and diaper expenses. In May, the two organized the second annual Period Party. “I’ve experienced period poverty throughout my life, and I didn’t know it was a thing that had a name to it,” Robarge said. After having her son in 2019 and struggling with a 60% cut in pay during her maternity leave, Robarge learned of the Diaper Mission. She now advocates for the end of the period poverty in Milwaukee. “I see how quickly the shelves empty out. I know in order to sustain this program, we have to keep the donations coming in,” Dachs said. The solution came to Dachs to celebrate menstruation, not just as a product drive, but as a party. The two invited friends, family and community members to a party and encouraged them to donate period supplies. The Period Party resulted in donations of 15,000 products this year. Tosa West Feminist Student Union volunteers load up a van with period kits to distribute to food pantries around Milwaukee. Milwaukee County Executive David Crowley packs the boxes of supplies into the van. Efforts felt citywide
Olivier said the Milwaukee Health Department has been able to provide thousands of diapers and hygiene items to some of the most at risk and vulnerable populations because of the Milwaukee Diaper Mission. Crowley said Milwaukee County is committed to ending period poverty. “We must commit ourselves as using a positive definition of health as a state of complete physical, mental and social well-being, not just the absence of disease,” Crowley said. “The work of the Milwaukee Diaper Mission in wiping out period poverty in our community is a shining example of that mission,” Crowley said. For more information
To donate or get involved with the Milwaukee Diaper Mission, visit its website at  https://www.milwaukeediapermission.org/ . Dachs also asks small businesses to join the fight to end period poverty. She will supply any business in the local area with a hand-decorated basket to put period products in their bathrooms. The businesses will also receive a certificate of recognition to display. To get a period product basket for a business, contact Nicole Dachs at her email:  dachsn3@gmail.com .

Milwaukee Diaper Mission Fights ‘Period Poverty’

"This has led to the risk contribution of obesity being significantly underestimated in many trials." To assess the magnitude of this bias, Brenner's researchers evaluated data from the DACHS study*. Representative ImageANI
7 May, 2023, 4:42 pm
HEIDELBERG [Germany]: Obesity is known to raise the risk of colorectal cancer. Research from the German Cancer Research Centre (DKFZ) suggested that the significance of this link has probably been grossly underestimated. The reason is that many patients unintentionally lose weight before being told they have colon cancer. Studies that only consider body weight at the time of diagnosis conceal the true relationship between obesity and the risk of colorectal cancer. The current study also shows that unintentional weight loss may act as a risk factor for colorectal cancer. Obesity puts people at risk for a wide range of cancers. For example, in the cases of colorectal, renal, and endometrial cancer, this association is very clear. According to earlier estimations, obese people had a roughly one-third higher risk of developing colon cancer than people of normal weight. "However, these studies have so far not taken into account that many affected people lose weight in the years before their colorectal cancer diagnosis," says Hermann Brenner, epidemiologist and prevention expert at the German Cancer Research Center. "This has led to the risk contribution of obesity being significantly underestimated in many trials." To assess the magnitude of this bias, Brenner's researchers evaluated data from the DACHS study*. The nearly 12,000 study participants included in the current evaluation had provided information on their body weight at the time of diagnosis and had also reported their weight in the years preceding diagnosis (measured at 10-year intervals). On the basis of body weight at the time of diagnosis, no indication of a relationship between body weight and colorectal cancer risk could be established. The picture was quite different, however, when the researchers looked at the participants' earlier body weight: Here, a strong correlation between overweight and the probability of developing colorectal cancer was found, which was most pronounced 8 to 10 years before diagnosis. Study participants who were highly overweight - referred to as obese- during this period were twice as likely as those of normal weight to develop colorectal cancer. "If we had only looked at weight at baseline, as has been done in many previous studies, we would have completely missed the link between obesity and increased risk of colorectal cancer," said Marko Mandic, the study's first author. Visit news.dtnext.in to explore our interactive epaper! Download the DT Next app for more exciting features!

Study finds out connection between obesity and colorectal cancer

'Merkel Entered Israelis' Hearts, but She Had No Trust in Netanyahu'
On the latest episode of Haaretz Weekly podcast, our guest Prof. Gisela Dachs analyzes Germany’s relationship with Israel in the era of the former Chancellor, and predicts 'continuity' under new leader Olaf Scholz
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Former German Chancellor Angela Merkel with Prime Minister Naftali Bennett in her farewell visit to Israel earlier this yearKobi Gideon/AFP
Angela Merkel was a strong supporter of Israel during her sixteen years as Germany’s Chancellor, despite her difficult relationship with Benjamin Netanyahu. Will Germany’s new, post-Merkel government, continue her policy regarding Israel, or take a different approach? This question is discussed in the latest episode of the Haaretz Weekly podcast, published on Tuesday. skip                            - LISTEN: How will Israel fare with post-Merkel Germany? Haaretz Weekly Podcast | The secret Israeli files revealing massacres of Palestinians. LISTEN
Professor Gisela Dachs of Hebrew University, who reported from Israel for leading German newspapers for over two decades, predicted a policy of “continuity” from the new Chancellor Olaf Scholz, leader of the Social Democrats. “Continuity will be the main point,” Dachs said on the podcast. “There could be more criticism of Israel from certain politicians in the coalition, but not from those at the top.”
According to Dachs, Merkel “managed something incredible with Israel: she entered the hearts of many Israelis, despite saying all the usual things that European leaders always say about settlements and the two-state solution.” And yet, she added, the former Chancellor “did not trust Benjamin Netanyahu, and she even said so.”
The media and the political system in Germany, Dachs said, are currently giving the new Bennett-led Israeli government a chance to formulate its policy, without putting pressure on it at the moment. “If Netanyahu was still in power,” she said, there would have been “more of a fuss” from Germany over recent Israeli announcements of construction in West Bank settlements. Still, Dachs said, Germany would like to know sooner rather than later where Bennett stands on the Palestinian issue, and what steps can be taken by this government toward resolving the conflict. Related Articles
Konstantin Nowotny, an editor at German weekly Der Freitag who is currently completing a fellowship with Haaretz via the International Journalist’ Programmes, was the second guest in the studio, discussing his recent report on Germany’s new foreign minister and her views on Israel. Nowotny said that Annalena Baerbock, leader of the Green Party and the first woman to lead the foreign ministry, had raised doubts in the past about arms sales to Israel, but has since regretted that comment and expressed strong commitment to the Germany-Israel relationship. Listen to the full episode, including an additional interview with Israeli historian Adam Raz about classified documents revealing new details about massacres of Palestinians in 1948, and how the Israeli government dealt with them.

'Merkel entered Israelis' hearts, but she had no trust in Netanyahu'

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