Predict your next investment

INDUSTRIAL | Construction / General Building Materials
customizedstructures.com

See what CB Insights has to offer

Stage

Leveraged Buyout | Dead

About Customized Structures

Provider of custom modular homes and buildings for residential, multi-family, and commercial use throughout New England. [Keywords: construction]

Customized Structures Headquarter Location

272 River Road

Claremont, New Hampshire, 03743,

United States

(800)523-2033

Latest Customized Structures News

Scientists Use Bacteria As Micro-3D Printers to Create Highly Customized Structures

Feb 17, 2021

By Aalto UniversityFebruary 17, 2021 The nanocellulose fibers created by the bacteria are about a thousand times thinner than the width of a human hair. Credit: Luiz Greca Technique creates highly customized structures that could be used in regenerative medicine. A team at Aalto University has used bacteria to produce intricately designed three-dimensional objects made of nanocellulose. With their technique, the researchers are able to guide the growth of bacterial colonies through the use of strongly water repellent – or superhydrophobic – surfaces. The objects show tremendous potential for medical use, including supporting tissue regeneration or as scaffolds to replace damaged organs. The results have been published in the journal ACS Nano. Unlike fibrous objects made through current 3D printing methods, the new technique allows fibers, with a diameter a thousand times thinner than a human hair, to be aligned in any orientation, even across layers, and various gradients of thickness and topography, opening up new possibilities for application in tissue regeneration. These kinds of physical characteristics are crucial for support materials in the growth and regeneration of certain types of tissues found in muscles as well as in the brain. “It’s like having billions of tiny 3D printers that fit inside a bottle,” explains Luiz Greca, a doctoral student at Aalto University. “We can think of the bacteria as natural microrobots that take the building blocks provided to them and, with the right input, create complex shapes and structures.” Once in a superhydrophobic mold with water and nutrients — sugar, proteins, and air — the aerobic bacteria produce nanocellulose. The superhydrophobic surface essentially traps a thin layer of air, which invites the bacteria to create a fibrous biofilm replicating the surface and shape of the mold. With time, the biofilm grows thicker and the objects become stronger. Using the technique, the researchers have created finely tuned structures like this model of lung alveolae. Credit: Valeria Azovskaya Using the technique, the team has created 3D objects with pre-designed features, measuring from one-tenth the diameter of a single hair all the way up to 15-20 centimeters. The nano-sized fibers do not cause adverse reactions when placed in contact to human tissues. The method could also be used to grow realistic models of organs for training surgeons or improving the accuracy of in-vitro testing. “It’s like having billions of tiny 3D printers that fit inside a bottle.” — Luiz Greca, doctoral student “It’s really exciting to expand this area of biofabrication that takes advantage of strong cellulose nanofibres and the networks they form. We’re exploring applications for age-related tissue degeneration, with this method being a step forward in this and other directions,” says research group leader Professor Orlando Rojas. He adds that the strain of bacteria used by the team, Komagataeibacter medellinensis, was discovered in a local market in the city of Medellin, Colombia, by previous collaborators from Universidad Pontificia Bolivariana. A superhydrophobic coating traps a layer of air between the mold and bacterial culture, guiding nanocellulose fiber growth. Credit: Luiz Greca In both nature and engineering, superhydrophobic surfaces are designed to minimize the adhesion of dust particles as well as microorganisms. This work is expected to open new possibilities for using superhydrophobic surfaces to precisely produce naturally manufactured materials. As the bacteria can be removed or left in the final material, the 3D objects can also evolve as a living organism over time. The findings provide an important step towards harnessing full control over bacterially fabricated materials. “Our research really shows the need to understand both the fine details of bacteria interaction at interfaces and their ability to make sustainable materials. We hope that these results will also inspire scientists working on both bacteria-repelling surfaces and those making materials from bacteria,” says Dr. Blaise Tardy. Reference: “Guiding Bacterial Activity for Biofabrication of Complex Materials via Controlled Wetting of Superhydrophobic Surfaces” by Luiz G. Greca, Mahdi Rafiee, Alp Karakoç, Janika Lehtonen, Bruno D. Mattos, Blaise L. Tardy and Orlando J. Rojas, 5 October 2020, ACS Nano.

Predict your next investment

The CB Insights tech market intelligence platform analyzes millions of data points on venture capital, startups, patents , partnerships and news mentions to help you see tomorrow's opportunities, today.

CB Insights uses Cookies

CBI websites generally use certain cookies to enable better interactions with our sites and services. Use of these cookies, which may be stored on your device, permits us to improve and customize your experience. You can read more about your cookie choices at our privacy policy here. By continuing to use this site you are consenting to these choices.