Connective Orthopaedics

NICO develops technology for the field of minimally invasive neurosurgery, including skull base and spinal surgery. The company's technology and products are designed and developed to impact patients' lives, families, caregivers, and health system providers. It provides patented technologies that integrate imaging and intervention for approaches to brain surgery. NICO was founded in 2007 and is based in Indianapolis, Indiana.

Tissue Regeneration Systems (TRS) is commercializing a skeletal reconstruction and bone reconstruction technology for the fabrication of bioresorbable implants. These implants fully replace themselves with natural bone over time, leaving no residual implanted device; moreover, although the micro-architecture of these implants is porous for the facilitation of bone integration, they can nonetheless bear load and are strong enough to support function without the need for reinforcement from metal plates. Such structural integrity enables them to be used as an alternative to harvested, autologous bone that is fixed with metallic plates for complex skeletal reconstruction. TRS implants are also integrated with an osteoconductive coating that enhances bone regeneration and proliferation; powerful orthobiologics and bone-growing autologous cells will readily bind to this coating, allowing for a controlled biologic release to further accelerate bone formation.

Regenesis is engaged in the development, manufacturing, and sale of biomedical devices that promote healing and skin wound closure more quickly and cost-effectively than existing standards of wound treatment. The company's devices are based on its Cell Proliferation Induction (CPI) technology, in which electromagnetic signals trigger the repair and regeneration of soft tissue cells.

Pegasus Biologics is developing advanced bioimplants for soft tissue reinforcement for orthopedics, sports medicine, neurosurgical and spine applications

Arbor Surgical Technologies, Inc. with facilities located in Irvine and Portola Valley, CA (USA), is a privately held cardiovascular medical device company focused on the heart valve replacement market. Founded in 2002 by Dr. Thomas J. Fogarty and noted heart valve designer, Ernie Lane, Arbor is developing multiple technologies that have the potential to deliver significant clinical benefit to patients worldwide. Arbor intends to develop and commercialize its core technologies in varying combinations, giving the company the opportunity to create a broad portfolio of product offerings. Currently in clinical trials, Arbor is developing a tissue heart valve family of products designed for improved performance over existing valves and compatible implantation tools that simplify and speed valve replacement surgery. Arbor Surgical Technologies mission is to simplify cardiac valve surgery through the innovative development of a less invasive, unique implantation system and valves with superior performance and durability. Partnering with physicians, we will improve patient recovery by less invasive techniques and reduced surgery time. Ethical behavior with employees, surgeons, patients and suppliers is the keystone to our success.

Primaeva Medical is an early stage medical device company developing a skin tightening and rejuvenation dermatological device