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HEALTHCARE | Drug Development
combimatrix.com

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Founded Year

1995

Stage

Acq - P2P | Acquired

Total Raised

$46.32M

Valuation

$0000 

About CombiMatrix

CombiMatrix's patented electrochemical manufacturing process utilizes standard semiconductor technology, proprietary software, and chemistry to build arrays of materials -- molecule by molecule.

CombiMatrix Headquarter Location

6500 Harbour Heights Parkway Suite 303

Mukilteo, Washington, 98275,

United States

425-493-2000

Latest CombiMatrix News

Tazarotene, halobetasol combination efficacious in scalp psoriasis

Nov 18, 2021

Disclosures: Kircik reports receiving either grant or honoraria from Abbott Laboratories, AbbVie, Allergan Inc., Almirall, Amgen Inc., Arcutis, Biogen-Idec, BMS, Boehringer Ingelheim, Breckenridge Pharma, Celgene, Centocor Inc., Cellceutix, Cipher, CombiMatrix, Connetics Corporation, Coria, Dermavant, Dermira, Dow Pharmaceutical Sciences Inc., Dr. Reddy’s Lab, Eli Lilly, Galderma, Genentech Inc., GlaxoSmithKline, PLC, Idera, Johnson & Johnson, Leo, Maruho, Merck, Medicis Pharmaceutical Corp., NovartisAG, Promius, PharmDerm, Pfizer, Serono (Merck Serono International SA), Stiefel Laboratories Inc., Sun Pharma, Taro, UCB, Valeant Pharmaceuticals Intl. and XenoPort. ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . Please try again later. If you continue to have this issue please contact customerservice@slackinc.com . Back to Healio Scalp psoriasis was improved with a fixed combination of tazarotene and halobetasol propionate lotion , according to an open-label pilot study. “About 80% of psoriasis patients have scalp involvement, which can be challenging to treat,” Elif Ozyurekoglu and Leon H. Kircik, MD, of the Ichan School of Medicine and Mount Sinai, wrote. “Fixed combination tazarotene 0.045% and halobetasol propionate 0.01% (Duobrii, Ortho Dermatologics) lotion has recently been approved for the treatment of moderate to severe plaque type psoriasis . The lotion base is suggested to confer benefits for application to the hair-bearing scalp.” A study found scalp psoriasis was improved with a fixed combination of tazarotene and halobetasol propionate lotion. The open-label, single-center pilot study included 21 patients (average age, 52 years; 57% men; 95% white) with moderate to severe plaque psoriasis, as defined by an Investigator Global Assessment (IGA) scale value of 3 or 4 with scalp involvement. Each patient was provided with the medication and instructed to apply the lotion to the affected areas once daily for 12 weeks. IGA scores were improved significantly at weeks 4, 8 and 12 with 10 (48%) patients reaching clear or almost clear status by week 8 (P = .0006). At week 12, 40% of subjects remained clear or almost clear (P = .004). Psoriasis scalp severity index (PSSI) 75 was achieved by 67% of patients at week 8, with 45% of patients maintaining PSSI 75 at week 12. PSSI 90 was achieved by 38% of subjects at week 8, with 30% maintaining at week 12. PSSI 100 was seen in 29% at week 8 with 20% maintaining at week 12. Scalp IGA of clear or almost clear was achieved by 15 (72%) patients at week 8 with 50% maintaining through week 12. In addition, 29% had a completely clear scalp at week 8, with 20% maintaining at week 12. There were no study-related adverse events. “Scalp psoriasis is a significant concern for affected patients, and treatment has remained challenging,” the authors wrote. “Results of this pilot study demonstrate that fixed combination tazarotene 0.045% and halobetasol propionate 0.01% lotion is efficacious for the treatment of scalp psoriasis in adults, based on significant improvements in IGA, PSSI, BSA, sIGA and DLQI.”

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Expert Collections containing CombiMatrix

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

CombiMatrix is included in 1 Expert Collection, including Biopharma Tech.

B

Biopharma Tech

5,238 items

Companies involved in the research, development, and commercialization of chemically- or biologically-derived therapeutic & theranostic drugs. Excludes vitamins/supplements, CROs/clinical trial services.

CombiMatrix Patents

CombiMatrix has filed 4 patents.

patents chart

Application Date

Grant Date

Title

Related Topics

Status

9/13/2004

5/18/2010

Molecular biology, Biotechnology, Microarrays, Nucleic acids, Hydrazines

Grant

Application Date

9/13/2004

Grant Date

5/18/2010

Title

Related Topics

Molecular biology, Biotechnology, Microarrays, Nucleic acids, Hydrazines

Status

Grant

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