Pennsylvania is home to the continuum of the biosciences - basic research, emerging companies, mature industry and global pharmaceuticals. Through Pennsylvania Bio these organizations interact to create a vibrant community. It is through the interactivity of this continuum that bioscience companies are spawned, are able to attract experienced managers and a talented workforce, and are able to grow and partner for advancement. It's all part of the company's mission: to be the catalyst to ensure Pennsylvania is engaged in biosciences by developing a cohesive community that unites the region's biotechnology, pharmaceutical, research and financial strengths.

BioProtection Systems (BPSC) is a biotechnology company located in the Iowa State University Research Park in Ames, Iowa. The company is developing vaccine solutions to increase the United States' biodefense capabilities.

AthenaES specializes in the development and commercialization of advanced biotechnology-based products. Throughout its eleven year history, the company has maintained a broad perspective for applying its core competency, the use of proteins and enzymes for commercial applications, to develop products. As such, the company currently markets its products and services through two business units and maintains an exploratory R&D group. The Athena Enzyme Systems Group aims to provide specialty reagents and proteins for the production and recovery of recombinant proteins along with providing contract R&D services. Products include: Expression Media, Serum-free Media, Protein Refolding kits, and the PDQ Protease Assay. This business unit also aims to provide specialized contract research, development and manufacturing services for the production of recombinant proteins. The Athena Environmental Services Group designs, develops and manufactures environmentally responsible products. Products developed include: The Bilge Pill, a biodegradable cleaning product for the removal of oil in boat bilges, and a plant nutrient supplement used in hydroponics, hobby gardens and horticulture that replaces conventional fertilizers, and the Sting Thing, an enzyme-based invertebrate sting treatment product. More recently, this group developed and has introduced a water-soluble, reversible glue, MagiGlue. The Athena Exploratory Science Group has the mission to pursue research with the potential for commercial, environmental and social impact. These projects are far reaching in their scope and represent high risk, high-value projects.

CombiSep Inc. has merged with Advanced Analytical Technologies, Inc. (AATI). aims to provide separation systems for the pharmaceutical, biotechnology, and chemical industries to increase productivity in discovery, development, and quality control processes. The cePRO 9600 system is a multiplexed capillary electrophoresis (CE) instrument providing near universal UV absorbance detection and the capability to perform 96 CE separations in parallel, increasing sample throughput. This technology aims to provide the company's customers with a key scientific and business advantage over traditional serial-based analytical methods, and aims to allow for quicker decisions on time-to-market strategies.

BioSphere was born in 1998 as the biotechnology division of S.F.I.R. S.p.A. with the aim of diversifying the activities in the biotech sector, and in particular for the development of technologies for the conversion of sugars and by-products of the agro-food industry into added value products. In 2002 BioSphere became an independent company with the capital fully hold by S.F.I.R. SpA. Today, BioSphere develops its own R&D projects and offers to other companies an efficient and qualified outsourcing service.

Spreading innovation in the Nano- and Biotechnology fields - this is the aim of Tethis. The company are heading for this goal through a tri-fold market approach reflected by the three business units of Tethis: Tethis Systems, Tethis Technology Services and Tethis Research. Tethis Systems focuses on the design and sale of nanoparticle synthesis and nanocoating units allowing customers to develop their own nanotech-products in-house. Tethis Technology Services supports customers with nano - and biotech product development by technical consulting and by opening Tethis' platform technologies for services such as tailor-made coatings or nanopowder development. Tethis Research targets on the incorporation of nanotechnology in devices, for instance by the integration of nanotechnology, biotechnology and microfabrication. Many of the company's research projects are based on collaborations with industries, universities and research centers reflecting the company's motto "Integration through collaboration".n