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HEALTHCARE | Drug Development
brightangeltherapeutics.com

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Founded Year

2017

Stage

Seed VC - II | Alive

About Bright Angel Therapeutics

Bright Angel Therapeutics is focused on the development of novel therapeutics for the treatment of drug-resistant and life-threatening fungal infections.

Bright Angel Therapeutics Headquarter Location

Toronto, Ontario,

Canada

Latest Bright Angel Therapeutics News

Bright Angel: New hope against fungal resistance

Apr 15, 2019

Bright Angel: New hope against fungal resistance How Bright Angel's HSP90 inhibitor could block antifungal resistance 3:45 PM Share PDF Bright Angel is tackling antifungal resistance at its root with inhibitors of Hsp90 and other stress response factors, unlike competitors that are developing compounds against known or new pathways where resistance can still emerge. Resistance to the three approved classes of antifungal agents -- azoles, polyenes and echinocandins -- is a growing problem, yet most compounds in development trod the same biological pathways as those classes. According to Bright Angel Therapeutics Inc. co-founder and CSO Leah Cowen, fungal and human proteins, such as Hsp90, share a high degree of homology, raising the potential for toxicity that hampers the development of new targets. Cowen also is a professor of molecular genetics at the University of Toronto. In a series of papers between 2005 and 2018, Cowen and the late Susan Lindquist reported that Hsp90 and other fungal proteins at the nexus of stress responses promoted drug tolerance and resistance. Lindquist was a director at the Whitehead Institute for Biomedical Research and Cowen was... Read the full 787 word article User Sign in

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