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SOFTWARE (NON-INTERNET/MOBILE) | Scientific, Engineering Software
braincorp.com

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Founded Year

2009

Stage

Series D | Alive

Total Raised

$150M

Last Raised

$36M | 1 yr ago

About Brain Corp

Brain Corp develops algorithms based on the functionality of the nervous system, with applications in visual perception, motor control, and autonomous navigation. Brain Corporation is working with Qualcomm Incorporated on designing specialized neuromorphic hardware to develop smart consumer products utilizing artificial nervous systems.

Brain Corp Headquarter Location

10182 Telesis Court Suite 100

San Diego, California, 92121,

United States

858-689-7600

Latest Brain Corp News

New Microscopy Technique Reaches Deeper Into the Living Brain

May 31, 2021

By The Optical SocietyMay 31, 2021 A new imaging method can capture images of vasculature deep in the brains of mice. A conventional widefield fluorescence image of the mouse brain taken non-invasively in the visible light spectrum is shown on the left, while the non-invasive localization-based DOLI approach operating in the NIR-II spectral window is shown on the right. Credit: Daniel Razansky, University and ETH Zurich Imaging method poised to bring new insight into how the brain works in health and disease. Researchers have developed a new technique that allows microscopic fluorescence imaging at four times the depth limit imposed by light diffusion. Fluorescence microscopy is often used to image molecular and cellular details of the brain in animal models of various diseases but, until now, has been limited to small volumes and highly invasive procedures due to intense light scattering by the skin and skull. “Visualization of biological dynamics in an unperturbed environment, deep in a living organism, is essential for understanding the complex biology of living organisms and progression of diseases,” said research team leader Daniel Razansky from the University of Zurich and ETH Zurich, both in Switzerland. “Our study represents the first time that 3D fluorescence microscopy has been performed fully noninvasively at capillary level resolution in an adult mouse brain, effectively covering a field of view of about 1 centimeter.” The new technique called diffuse optical localization imaging (DOLI) takes advantage of the NIR-II spectral window from 1000 to 1700 nanometers, which exhibits less scattering. First author Quanyu Zhou is shown with the imaging setup. Credit: Daniel Razansky, University of Zurich and ETH Zurich In Optica, The Optical Society’s (OSA) journal for high impact research, the researchers describe their new technique, which is called diffuse optical localization imaging (DOLI). It takes advantage of what is known as the second near-infrared (NIR-II) spectral window from 1000 to 1700 nanometers, which exhibits less scattering. “Enabling high-resolution optical observations in deep living tissues represents a long-standing goal in the biomedical imaging field,” said Razansky. “DOLI’s superb resolution for deep-tissue optical observations can provide functional insights into the brain, making it a promising platform for studying neural activity, microcirculation, neurovascular coupling and neurodegeneration.” Achieving greater depth For the new technique, the researchers intravenously inject a living mouse with fluorescent microdroplets at a concentration that creates a sparse distribution in the blood stream. Tracking these flowing targets enables reconstruction of a high-resolution map of the deep cerebral microvasculature in the mouse brain. The researchers tested the new technique in tissue phantoms that mimic average brain tissue properties, demonstrating that they could acquire microscopic resolution images at depths of up to 4 millimeters in optically opaque tissues. Credit: Daniel Razansky, University of Zurich and ETH Zurich “The method eliminates background light scattering and is performed with the scalp and skull intact,” said Razansky. “Interestingly, we also observed strong dependence of the spot size recorded by the camera on microdroplet’s depth in the brain, which enabled depth-resolved imaging.” The new approach benefits from the recent introduction of highly efficient short-wave infrared cameras based on InGaAs sensors. Another key building block was the use of novel contrast agents exhibiting strong fluorescence responses in the NIR-II window, such as lead sulfide (PbS)-based quantum dots. Crisp and clear imaging The researchers first tested the new technique in synthetic models of tissue known as tissue phantoms that mimic average brain tissue properties, demonstrating that they could acquire microscopic resolution images at depths of up to 4 millimeters in optically opaque tissues. They then performed DOLI in living mice where cerebral microvasculature as well as blood flow velocity and direction could be visualized entirely noninvasively. The researchers are working to optimize precision in all three dimensions to improve DOLI’s resolution. They are also developing improved fluorescent agents that are smaller, have stronger fluorescence intensity and are more stable in vivo. This will significantly boost DOLI’s performance in terms of the achievable signal to noise and imaging depth. “We expect that DOLI will emerge as a powerful approach for fluorescence imaging of living organisms at previously inaccessible depth and resolution regimes,” said Razansky. “This will greatly enhance the in vivo applicability of fluorescence microscopy and tomography techniques.” Reference: “Diffuse optical localization imaging for noninvasive deep brain microangiography in the NIR-II window” by Quanyu Zhou, Zhenyue Chen, Justine Robin, Xosé-Luís Deán-Ben and Daniel Razansky, 27 May 2021, Optica.

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Research containing Brain Corp

Get data-driven expert analysis from the CB Insights Intelligence Unit.

CB Insights Intelligence Analysts have mentioned Brain Corp in 2 CB Insights research briefs, most recently on Dec 3, 2020.

Expert Collections containing Brain Corp

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

Brain Corp is included in 6 Expert Collections, including In-Store Retail Tech.

I

In-Store Retail Tech

1,414 items

Startups aiming to work with retailers to improve brick-and-mortar retail operations.

S

Supply Chain & Logistics Tech

2,931 items

Companies offering technology-driven solutions that serve the supply chain & logistics space (e.g. shipping, inventory mgmt, last mile, trucking).

R

Robotics

1,636 items

This collection includes startups developing autonomous ground robots, unmanned aerial vehicles, robotic arms, and underwater drones, among other robotic systems. This collection also includes companies developing operating systems and vision modules for robots.

G

Grocery Retail Tech

300 items

Startups providing B2B solutions to grocery businesses to improve their store and omni-channel performance. Includes customer analytics platforms, in-store robots, predictive inventory management systems, online enablement for grocers and consumables retailers, and more.

A

AI 100 2018

99 items

G

Game Changers 2018

70 items

Brain Corp Patents

Brain Corp has filed 146 patents.

The 3 most popular patent topics include:

  • Machine learning
  • Artificial neural networks
  • Robotics
patents chart

Application Date

Grant Date

Title

Related Topics

Status

12/28/2018

4/27/2021

Method and system for machine-implemented game with multiple game incentive

Poker variants, Poker gameplay and terminology, Playing cards, Diagrams, Texas hold 'em

Grant

7/27/1997

3/5/1965

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12/28/1985

6/30/1980

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8/21/1970

6/13/1953

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9/4/1975

4/27/1955

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Application Date

12/28/2018

11/21/1978

6/4/1968

7/15/1951

4/18/1980

Grant Date

4/27/2021

7/1/2016

7/27/1954

1/20/1979

12/26/2014

Title

Method and system for machine-implemented game with multiple game incentive

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Related Topics

Poker variants, Poker gameplay and terminology, Playing cards, Diagrams, Texas hold 'em

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