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Stage

Grant | Alive

Total Raised

$350K

Last Raised

$150K | 14 yrs ago

About Bioprocessing Innovative Company

Bioprocessing Innovative Company is a company that received a STTR Phase I grant for a project entitled: Engineering Clostritrial Fermentation for Biobutanol Production. Their project will develop novel engineered Clostridia strains for fermentation to economically produce butanol as a biofuel from sugars derived from starchy and lignocellulosic biomass. Butanol is an important industrial solvent and potentially a better transportation fuel than ethanol. Recent rising oil prices and limited petroleum resources have generated high interest in the production of biobutanol by anaerobic Clostridial fermentation. However, the conventional acetone-butanol-ethanol (ABE) fermentation has low butanol yield (<20%), butanol concentration (<16 g/L) and reactor productivity (<0.5 g/L*h) due to a strong butanol inhibition, and the fermentation process is difficult to improve due to the complicated metabolic pathways and gene regulation involved in the production microorganisms, mainly Clostridium acetobutylicum. To develop a novel high-butanol producer, Clostridia mutant strains with inactivated ack (acetate kinase) and pta (phosphotransacetylase) will be cloned with an alcohol dehydrogenase gene in Phase I and the mutants will be further adapted in a fibrous bed bioreactor to attain a high butanol tolerance. Functional genomic studies of the mutants and further metabolic engineering and process development will be carried out in Phase II to evaluate the feasibility and advantages of producing butanol from glucose and xylose. The new fermentation process can double the butanol yield and concentration, thus reducing the product cost to an economically competitive level for fuel application. Broader Impact: Currently, butanol is almost exclusively produced via petrochemical routes. Its uses include industrial applications in solvent, rubber monomers and brake fluids. Butanol has also been shown to be a good alternative transportation fuel. Biobutanol will have a great potential to compete with ethanol as a transportation fuel when its production cost is reduced by using advanced fermentation technologies such as metabolically engineered butanol-tolerant mutants. By increasing the butanol yield from glucose and xylose from the current low of <20 % (w/w) to ~40%, the economics of biobutanol can be greatly improved. With the engineered mutants, the productivity and butanol product concentration can also be improved by at least 100%. Overall, the biobutanol product cost can be reduced to less than $2 per gallon. This technology thus can provide an economical and better biofuel than ethanol. This project will focus on generation of value-added products from industrial waste streams and low-cost biomass feedstocks to enhance the economic viability of the biorefinery industry. Successfully developing the proposed butanol fermentation technology will satisfy the public interest, especially in providing a safe, renewable energy, protecting natural resources and the environment, and enhancing economic opportunity and quality of life. There will be job creation throughout the commercial development and manufacturing phases. At least one postdoctoral scholar and one Ph.D. student will be trained in this project. Bioprocessing Innovative Company is a company that received a STTR Phase I grant for a project entitled: A Gas-Solid Spouted Bed Bioreactor for Solid State Fermentation to Produce Enzymes and Biochemicals from Plant Biomass. Their research project will develop a gas-solid spouted bed bioreactor (SBB) for solid state fermentations (SSF) to produce hydrolytic enzymes (e.g., amylases, phytase, chitinase) and biochemicals (e.g., lactic acid) from solid starch materials. SSF offers higher production rates and easier product recovery compared to submerged fermentation (SmF), along with the ability to use many agricultural commodities and byproducts, such as rice, corn and wheat bran, as substrates. By virtue of its use of plant biomass as a substrate, SSF can become a sustainable system of chemical production from natural resources, thereby providing economic benefit to US agriculture and increasing national competitiveness. The proposed gas-solid spouted bed bioreactor can overcome problems suffered by conventional SSF systems. Using SBB for enzyme production potentially can reduce enzyme costs by more than 75% and thus increase their applications. Commercially, this new solid state fermentation (SFF) process can be used for economical production of industrially important enzymes from solid plant biomass. Hydrolyases such as amylases, cellulases, phytase, and chitinase have wide applications in industry. These enzymes can be more economically produced from plant biomss in SSF using the spouted bed bioreactor. Amylases and many other hydrolase enzymes are used in bioprocessing, including corn wet-milling, which currently generates more than $24.4 billion market value. Reducing the costs of these hydrolyase enzymes is critical to the emerging biorefinery and bio-based industrial products. The gas-solid spouted bed bioreactor (SBB) also can be used in simultaneous saccharification and fermentation processes for biochemicals production from plant biomass containing starch or cellulose. Successfully developing the proposed SBB and SSF technologies will provide sustainable chemical production, protect natural resources and the environment, and enhance economic opportunity and quality of life. The project also will train high quality personnel in the much needed bioprocessing technology areas, and provide an infrastructure for timely commercialization of university research results. There will be job creation throughout the commercial development and manufacturing phases. Bioprocessing Innovative Company is a company that received a SBIR Phase I grant for a project entitled: Production and Separation of Galacto-Oligosaccharides from Lactose for Prebiotic Food Applications. Their project will develop a novel immobilized enzyme process to produce galactooligosaccharides (GOS) from whey lactose for probiotic food applications. The proposed GOS production process involves two immobilized enzyme reactors and product separation by nanofiltration and adsorption chromatography. Two different alpha-galactosidase enzymes with different GOS formation characteristics will be used to optimize GOS production and yield from lactose. The product stream from the second reactor will be sent to a nanofiltration (NF) separation unit, where GOS, lactose, galactose, and glucose could be separated to yield a product with a higher GOS composition. The process for adsorption with activated carbon and ion exchange liquid chromatography will be developed to further purify GOS. The commercial application of this project will be in the emerging probiotic and neutraceutical food market for use by both animals and humans. This market is estimated to be in excess of 2 billion dollars per year. The present use of GOS in foods is limited by the high production costs. These costs are attributed mainly to the high enzyme cost and low oligosaccharide yields (less than 30% w/w). The proposed technology is expected to reduce production costs by at least 50% due by improving reactor productivity and enzyme life. Further, the ability to use cheap whey precursor products (current price range : $ 0.12 - $ 0.40 per lb) to value added GOS product (curent price : $ 4 - $ 5 per lb) will be of great benefit to the diary industry.

Bioprocessing Innovative Company Headquarter Location

4734 Bridal Path Court

Dublin, Ohio, 43017,

United States

614-761-1552

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Expert Collections containing Bioprocessing Innovative Company

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Bioprocessing Innovative Company is included in 1 Expert Collection, including Renewable Energy.

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Renewable Energy

2,797 items

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  • Where is Bioprocessing Innovative Company's headquarters?

    Bioprocessing Innovative Company's headquarters is located at 4734 Bridal Path Court, Dublin.

  • What is Bioprocessing Innovative Company's latest funding round?

    Bioprocessing Innovative Company's latest funding round is Grant.

  • How much did Bioprocessing Innovative Company raise?

    Bioprocessing Innovative Company raised a total of $350K.

  • Who are the investors of Bioprocessing Innovative Company?

    Investors of Bioprocessing Innovative Company include National Science Foundation.

  • Who are Bioprocessing Innovative Company's competitors?

    Competitors of Bioprocessing Innovative Company include Fulcrum BioEnergy, Terra-Gen, Concepts NREC, Renew Financial, Inetec and 12 more.

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