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BioMarck Pharmaceuticals

biomarck.com

Stage

Unattributed | Alive

Total Raised

$21.5M

Last Raised

$750K | 6 yrs ago

About BioMarck Pharmaceuticals

BioMarck Pharmaceuticals is a biopharmaceutical company dedicated to the discovery and development of drugs for the treatment of pulmonary diseases and disorders associated with the over-secretion of mucus and pulmonary inflammation. In developing its lead compound, BIO-11006 Inhalation Solution, BioMarck has chosen chronic obstructive pulmonary disease (specifically chronic bronchitis) as its first target, but other diseases including asthma, and cystic fibrosis are later disease targets. BIO-11006 Inhalation Solution works by a novel dual mechanism; it inhibits both the secretion of mucus in the lungs and pulmonary inflammation. These aspects of BIO-11006 Inhalation Solution have been demonstrated in several different animal models. In addition, BioMarck has completed a full panel of preclinical safety studies, has an active IND with the FDA, has completed two BIO-11006 in Phase 1 clinical studies, and is currently conducting a Phase 2 study of the efficacy of BIO-11006 in COPD patients.

Headquarters Location

2530 Meridian Parkway Suite 300

Durham, North Carolina, 27713,

United States

844-424-6627

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Expert Collections containing BioMarck Pharmaceuticals

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

BioMarck Pharmaceuticals is included in 1 Expert Collection, including Biopharma Tech.

B

Biopharma Tech

838 items

BioMarck Pharmaceuticals Patents

BioMarck Pharmaceuticals has filed 1 patent.

The 3 most popular patent topics include:

  • G protein coupled receptors
  • Immunology
  • Protein domains
patents chart

Application Date

Grant Date

Title

Related Topics

Status

6/12/2020

10/11/2022

Molecular biology, Transcription factors, DNA, RNA, Nucleic acids

Grant

Application Date

6/12/2020

Grant Date

10/11/2022

Title

Related Topics

Molecular biology, Transcription factors, DNA, RNA, Nucleic acids

Status

Grant

Latest BioMarck Pharmaceuticals News

Results of Biomarck Clinical and Preclinical Studies of BIO-11006 in ARDS to be Presented at the 2021 ARDS Drug Development Summit

Jul 7, 2021

July 07, 2021 07:07 AM Eastern Daylight Time NEWTOWN, Pa.--( BUSINESS WIRE )-- Biomarck Pharmaceuticals, Ltd., a clinical-stage biopharmaceutical company focused on developing peptides that inhibit MARCKS to treat patients with inflammatory diseases, today announced that data from clinical and preclinical studies of BIO-11006, the Company’s lead peptide, will be presented during the 2021 ARDS Drug Development Summit, a virtual event being held July 13 – 15, 2021. In the Phase 2 clinical study, rapid and faster improvements in oxygenation were observed in patients receiving BIO-11006 compared to placebo (half normal saline), together with decreases in pro-inflammatory cytokines. At 28 days there were 7 deaths (37%) in the placebo arm and 4 deaths (21%) in the BIO-11006 treatment arm. BIO-11006 was effective in three preclinical mouse models, lipopolysaccharide (LPS), Strep. pneumoniae and lipoteichoic acid (LTA). Treatment with BIO-11006 prevented development of ARDS, reversed established ARDS and prevented neutrophil influx into the lungs. Professor Kenneth Adler, PhD, Professor of Cell Biology at North Carolina State University’s College of Veterinary Medicine, and Presenter at the Summit, commented, “Compelling evidence of efficacy has been demonstrated with BIO-11006 in preclinical models and in a Phase 2 study. It is hoped that these results can now be repeated in a larger clinical trial currently being planned.” The presentation will be available after the summit on the Biomarck website in the Publications section www.biomarck.com/publications . About Biomarck Biomarck Pharmaceuticals, Ltd., is a clinical stage biotechnology company focused on treating patients with inflammatory and immunological diseases, using our platform of patent-protected peptides that have been developed to inhibit MARCKS. As a critical component of the inflammatory process, MARCKS is responsible for neutrophil aggregation at the site of inflammation and cytokine release. Inhibiting MARCKS with our peptides reduces the adverse effects of inflammation, including acute respiratory distress syndrome (ARDS) and cytokine storm. Phase 2 trials have been completed with our lead peptide, BIO-11006, in ARDS, COPD and NSCLC, confirming safety and efficacy in these three potential indications. In vivo data demonstrate that BIO-11006 and other peptides in the Biomarck pipeline inhibit inflammation in dermatology and ophthalmology models. Potential indications include uveitis, dry eye, atopic dermatitis and psoriasis. Contacts

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BioMarck Pharmaceuticals Frequently Asked Questions (FAQ)

  • Where is BioMarck Pharmaceuticals's headquarters?

    BioMarck Pharmaceuticals's headquarters is located at 2530 Meridian Parkway, Durham.

  • What is BioMarck Pharmaceuticals's latest funding round?

    BioMarck Pharmaceuticals's latest funding round is Unattributed.

  • How much did BioMarck Pharmaceuticals raise?

    BioMarck Pharmaceuticals raised a total of $21.5M.

  • Who are the investors of BioMarck Pharmaceuticals?

    Investors of BioMarck Pharmaceuticals include National Institutes of Health.

  • Who are BioMarck Pharmaceuticals's competitors?

    Competitors of BioMarck Pharmaceuticals include Aerie, Oligomerix, Sound Pharmaceuticals, Acumen Pharmaceuticals, Portola Pharmaceuticals, VIVUS, Mutabilis, Keryx Biopharmaceuticals, Orexigen Therapeutics, BaroFold and 48 more.

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