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aTyr Pharma

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About aTyr Pharma

aTyr Pharma is engaged in the discovery and clinical development of innovative medicines for patients suffering from severe rare diseases using its knowledge of Physiocrine biology, a newly discovered set of physiological modulators. To protect this pipeline, aTyr built an intellectual property estate comprising 24 patents and over 200 pending patent applications that are solely owned or exclusively licensed by aTyr. aTyr's key programs are currently focused on severe, rare diseases characterized by immune dysregulation, for which there are currently limited or no treatment options.

Headquarters Location

3545 John Hopkins Court Suite 250

San Diego, California, 92121,

United States


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aTyr Pharma's Products & Differentiators


    Efzofitimod is a first-in-class immunomodulator that downregulates innate and adaptive immune responses in uncontrolled inflammatory disease states via selective modulation of neuropilin-2 (NRP2)

Expert Collections containing aTyr Pharma

Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.

aTyr Pharma is included in 1 Expert Collection, including Biopharma Tech.


Biopharma Tech

1,568 items

aTyr Pharma Patents

aTyr Pharma has filed 116 patents.

The 3 most popular patent topics include:

  • Molecular biology
  • Protein domains
  • Clusters of differentiation
patents chart

Application Date

Grant Date


Related Topics




Immunology, Clusters of differentiation, Psychotherapy, Drug discovery, Protein domains


Application Date


Grant Date



Related Topics

Immunology, Clusters of differentiation, Psychotherapy, Drug discovery, Protein domains



Latest aTyr Pharma News

aTyr Pharma Presents New Data on Efzofitimod Mechanism of Action and Positive Exposure-Response at the American Thoracic Society 2023 International Conference

May 22, 2023

Location: Ballroom C (Level 3), Walter E. Washington Convention Center The poster presents findings that investigate the modulatory functions of efzofitimod on monocytes by evaluating peripheral blood mononuclear cells from pulmonary sarcoidosis patients or healthy donors for surface marker expression by flow cytometry and cytokine/chemokine secretion by immunoassay. Neuropilin-2, the binding partner for efzofitimod, is expressed on circulating monocytes and macrophages in lung granulomas from pulmonary sarcoidosis patients and exhibits a more inflammatory phenotype compared to healthy donors. Efzofitimod modulates immune responses in myeloid cells by downregulating pro-inflammatory cytokines and receptors that are dysregulated in sarcoidosis, including TNFa, IL-6, MIP-1a and MCP-1. These findings enhance our understanding of efzofitimod’s mechanism of action and demonstrate the way in which it modulates inflammatory responses in pulmonary sarcoidosis patients. Location: Area F, Hall C (Lower Level), Walter E. Washington Convention Center The poster presents findings from a population pharmacokinetic model and exposure-efficacy analyses using data from a Phase 1 study of efzofitimod in healthy volunteers and Phase 1b/2a study in patients with pulmonary sarcoidosis. Analyses assessed the relationship between efzofitimod exposure and three prespecified efficacy parameters and showed that administration of efzofitimod led to an exposure-dependent decrease in the extent of oral corticosteroid usage, increase in lung function as measured by percent predicted forced vital capacity and improvement in clinical symptoms as measured by the King’s Sarcoidosis Questionnaire-Lung score. These findings of a positive exposure-efficacy analysis across multiple clinically relevant endpoints support proof-of-concept and efficacy in pulmonary sarcoidosis. The company is also hosting an Industry Theater presentation. Details appear below. Title: Efzofitimod: An Emerging Treatment for Sarcoidosis? Session Format: Industry Theater Presentation Speaker: Daniel A. Culver, D.O, Chair of Pulmonary Medicine, Cleveland Clinic Date and Time: Tuesday, May 23, 2023, at 1:30 p.m. Location: Exhibit Hall A-B, Booth #102, Walter E. Washington Convention Center Dr. Culver will discuss efzofitimod as an emerging treatment for sarcoidosis, including its novel mechanism as a way to resolve inflammation and prevent the progression of fibrosis in patients with pulmonary sarcoidosis and the Phase 3 EFZO-FIT™ study, which is currently enrolling patients with pulmonary sarcoidosis. About Efzofitimod aTyr is developing efzofitimod as a potential therapeutic for patients with fibrotic lung disease. Efzofitimod, a fusion protein comprised of the immunomodulatory domain of histidyl-tRNA synthetase fused to the FC region of a human antibody, is a selective modulator of neuropilin-2 that downregulates innate and adaptive immune response in inflammatory disease states. aTyr’s lead indication for efzofitimod is pulmonary sarcoidosis, a major form of interstitial lung disease. Clinical proof-of-concept for efzofitimod was recently established in a Phase 1b/2a multiple-ascending dose, placebo-controlled study of efzofitimod in patients with pulmonary sarcoidosis, which demonstrated safety and a consistent dose response and trends of benefit of efzofitimod compared to placebo on key efficacy endpoints, including steroid reduction, lung function, clinical symptoms and inflammatory biomarkers. aTyr is currently conducting EFZO-FIT™, a global pivotal Phase 3 study of efzofitimod in pulmonary sarcoidosis. About aTyr aTyr is a biotherapeutics company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform. aTyr’s research and development efforts are concentrated on a newly discovered area of biology, the extracellular functionality and signaling pathways of tRNA synthetases. aTyr has built a global intellectual property estate directed to a potential pipeline of protein compositions derived from 20 tRNA synthetase genes and their extracellular targets. aTyr’s primary focus is efzofitimod, a clinical-stage product candidate which binds to the neuropilin-2 receptor and is designed to downregulate immune engagement in fibrotic lung disease. For more information, please visit . Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are usually identified by the use of words such as “believes,” “expects,” “intends,” “may,” “plans,” “forward,” “potential,” “will,” and variations of such words or similar expressions. We intend these forward-looking statements to be covered by such safe harbor provisions for forward-looking statements and are making this statement for purposes of complying with those safe harbor provisions. These forward-looking statements include, among others, statements regarding the potential of efzofitimod to be a transformative, disease modifying therapy for ILD, and the potential applications of efzofitimod. These forward-looking statements also reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Although we believe that our plans, intentions, expectations, strategies and prospects, as reflected in or suggested by these forward-looking statements, are reasonable, we can give no assurance that the plans, intentions, expectations or strategies will be attained or achieved. All forward-looking statements are based on estimates and assumptions by our management that, although we believe to be reasonable, are inherently uncertain. Furthermore, actual results may differ materially from those described in these forward-looking statements and will be affected by a variety of risks and factors that are beyond our control including, without limitation, uncertainty regarding geopolitical and macroeconomic events, risks associated with the discovery, development and regulation of our product candidates, the risk that we or our partners may cease or delay preclinical or clinical development activities for any of our existing or future product candidates for a variety of reasons (including difficulties or delays in patient enrollment in planned clinical trials), the possibility that existing collaborations could be terminated early, and the risk that we may not be able to raise the additional funding required for our business and product development plans, as well as those risks set forth in our most recent Annual Report on Form 10-K, Quarterly Report on Form 10-Q and in our subsequent SEC filings. Except as required by law, we assume no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise. Contact:

aTyr Pharma Frequently Asked Questions (FAQ)

  • When was aTyr Pharma founded?

    aTyr Pharma was founded in 2005.

  • Where is aTyr Pharma's headquarters?

    aTyr Pharma's headquarters is located at 3545 John Hopkins Court, San Diego.

  • What is aTyr Pharma's latest funding round?

    aTyr Pharma's latest funding round is PIPE.

  • How much did aTyr Pharma raise?

    aTyr Pharma raised a total of $180.5M.

  • Who are the investors of aTyr Pharma?

    Investors of aTyr Pharma include EcoR1 Capital, Sphera Funds, Deerfield Management, T. Rowe Price, Federated Investors and 10 more.

  • Who are aTyr Pharma's competitors?

    Competitors of aTyr Pharma include Humanetics, Arena Pharmaceuticals, Eyegate Pharmaceuticals, Santaris Pharma, MacroGenics and 16 more.

  • What products does aTyr Pharma offer?

    aTyr Pharma's products include Efzofitimod.

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