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Knowledge Mapping and Research Hotspots of Generalized Pustular Psoriasis: A Bibliometric Analysis from 2003 to 2023

Dec 20, 2023

Lu Wei,1 Buxin Zhang,2 Li Wang,2 Juntao Xu,2 Aimin Liu1,2 1Department of Dermatology, Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China; 2Department of Dermatology, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, People’s Republic of China Correspondence: Aimin Liu, Department of Dermatology, Henan Province Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, No, 6, Dongfeng Road, Jinshui District, Zhengzhou city, Henan Province, 450053, People’s Republic of China, Tel +86 13592603226, Fax +86-371-60973329, Email [email protected] Background: Generalised pustular psoriasis (GPP) is a chronic inflammatory skin disease. We aimed to visualize the research hotspots and trends of GPP using bibliometric analysis to enhance our comprehension of the future advancements in both basic science and clinical research. Methods: Relevant publications from July 2003 to July 2023 were obtained from the Web of Science Core Collection on July 12, 2023. The analysis of countries, institutions, authors, references, and keywords associated with this subject was conducted through the utilisation of CiteSpace 6.2.R4, VOSviewer 1.6.18, and Microsoft Excel 2019. Results: A total of 578 papers were analyzed, authored by 2758 researchers from 191 countries/regions and 1868 institutions, published in 174 academic journals. There was an overall upward trajectory in the volume of annual publications, accompanied by a gradual intensification of research interest in GPP. The United States, UDICE-French Research Universities, and Akiyama M of Nagoya University were the most productive and influential country, institution, and author, respectively. The Journal of Dermatology ranked first with the highest publications, and the Journal of the American Academy of Dermatology received the most citations. High-frequency keywords included “generalized pustular psoriasis”, “psoriasis, interleukin-36”, “plaque psoriasis”, “skin-disease”, and “antagonist deficiency”. Recent research focuses have included “safety”, “secukinumab”, “spesolimab”, “ap1s3 mutations”, and “interleukin-36”. Burst detection analysis of keywords showed that “moderate”, “ixekizumab treatment”, “mutations”, “efficacy”, and “safety” are current research frontiers in this field. Conclusion: This bibliometric analysis delineated the landmark publications in GPP that have defined current research hotspots and development trends, notably the applications, efficacy, and safety of biological agents. Future research endeavors are warranted to explore other biological therapeutic options for both acute GPP and the long-term management of chronic GPP. Keywords: generalised pustular psoriasis, psoriasis, interleukin-36, developing trends, bibliometric analysis Introduction Psoriasis is a chronic-inflammatory cutaneous disease that exhibits diverse clinical manifestations. The most common form of psoriasis, known as plaque psoriasis, primarily arises from adaptive immune system abnormalities. 1 Generalized pustular psoriasis (GPP), a more severe and infrequent subtype of psoriasis that may be life-threatening, is associated with excessive activation of the innate immune system. GPP is characterized by widespread eruptions of sterile, macroscopic pustules that manifest with or without signs of systemic inflammation. 2 , 3 The management of GPP poses significant challenges, mostly due to the difference in pathogeneses compared to plaque psoriasis. 4 It is now understood that GPP has an indirect impact on the economy through exacerbation of work productivity impairment. 5 However, a lack of global consensus on the clinical criteria for GPP diagnosis and treatment goal establishment persists. However, no consensus has been reached regarding the clinical criteria for diagnosing GPP and establishing treatment goals. Accordingly, a comprehensive exploration of GPP is crucial, as it will facilitate the development of novel concepts for clinical prevention and treatment approaches. Bibliometric analysis is a prominent form of scholarly investigation that assesses intrinsic relationships and dissemination patterns within the study literature, aiming to identify the most popular subjects, hotspots, and rapidly growing subfields, facilitating knowledge sharing among experts. 6 This study aims to provide physicians and researchers with a comprehensive historical analysis of GPP hotspots and scientific advancements over the previous twenty-year period, based on the findings derived from data analysis in the existing literature. The research findings will contribute to a deeper understanding of the subject, hence generating novel concepts for basic research, clinical prevention, and treatment strategies. Methods The Web of Science Core Collection (WoSCC) is a globally recognized and influential citation index database that covers a broad spectrum of research types and is commonly employed in bibliometric research. 7 The search query was formulated as TS = (“generalized pustular psoriasis”), encompassing a time frame spanning from July 12, 2003, to July 12, 2023. The searches and data exports were performed on a certain date (July 12, 2023) due to the dynamic nature of metrics that continually fluctuate over time. The language utilized in the publications was English. The possible publication types were limited to “articles” and “reviews”. Two researchers conducted an independent secondary screening of the retrieved articles by assessing the titles and abstracts to ensure they were relevant to the research subject. A third researcher resolved discrepancies and uncertainties during the selection process. Details of the process of the literature inclusion and exclusion process are presented in Figure 1 . Figure 1 The flow diagram of literature enrollment and data screening. To facilitate visual analysis, all relevant data collected from WoSCC were exported to Microsoft Excel 2019, VOSviewer 1.6.19, and CiteSpace 6.2.R4. Results The Trend of Publication Outputs Figure 2 illustrates the correlation between the quantity of articles published over specific time periods and the overall trajectory of research advancement within this discipline. Between 2003 and 2009, there was a notable dearth in publishing outputs, indicating that research during this period was in its nascent phase. From 2010 to 2021, despite occasional fluctuations, the quantity of published papers displayed an overall increasing trend, signifying growing interest in GPP. Global interest peaked in 2022, with 82 publications. As of July 12, 2023, the total number of articles now stands at 42. However, it is anticipated that this figure will undergo further growth in the future. Figure 2 The annual number of publications related to GPP (2003–2023). Distribution of Countries and Institutions A total of 578 scholarly publications originated from 191 nations and were affiliated with 1868 academic organizations. According to the data presented in Table 1 , the United States contributed the highest quantity of publications (161, 19.1%), followed by Japan (115, 13.7%), and China (93, 11.1%). International networks of cooperation are depicted in Figure 3A . Germany (0.76), the United States (0.38), and Italy (0.29) had the highest centrality scores. Table 1 Ranking of Top-10 Countries That Have Published the Most Article from 2003 to 2023 Figure 3 (A) Cooperation network of prolific countries/regions. (B) Visualization map of institutions’ cooperative relations. Table 2 illustrates the top ten most prolific organizations. UDICE-French Research Universities published 27 papers, making it the leading research institution in terms of contribution to this area. France is home to four of the top ten institutions. Figure 3B displays the institutionalized network map of collaboration. Only a handful of institutions demonstrated active cooperation, like UDICE-French Research Universities and Harvard University. However, numerous nations and research institutes were geographically dispersed and exhibited limited collaboration. Table 2 Ranking of Top-10 Institutions from 2003 to 2023 Authors and Co-Cited Authors The literature on GPP included 2758 authors. For the cooperation network analysis, only authors with a frequency of at least four times were included, resulting in a subset of 94 authors ( Figure 4 ). Table 3 lists the top ten most prolific scholars. Akiyama M demonstrated the highest level of scholarly productivity, having authored 15 articles. Bachelez H achieved the highest citation ranking (784 citations). Akiyama M, Burden AD, and Morita A had the highest H-index value. Despite not ranking first in terms of article publication, Morita A occupied a central position in the network, displaying strong collaborative ties with other research groups. Table 3 Ranking of Top-10 Most Productive Authors from 2003 to 2023 Figure 4 Collaborative network map among authors. Analysis of Journals and Cited Journals A total of 174 journals were considered relevant for this study. The top ten most prolific journals are detailed in Table 4 , with a predominant focus on clinical dermatology. In this respect, the Journal of Dermatology led in publications, accounting for 11.28% of the total (65 publications). Table 4 Ranking of Top-10 Most Productive Journals from 2003 to 2023 Among the top ten journals, the Journal of the American Academy of Dermatology held the highest impact factor (IF) at 13.8, with six journals situated in the first quartile (Q1) and four journals having an IF of 5.0 or higher, indicating that articles related to GPP demonstrate high quality and substantial academic merit. The application of a dual-map overlay technique facilitated the visualization of subject distribution and interconnections among various academic journals. Figure 5 illustrates five major citation relationships. For instance, the yellow route indicates that publications in journals focusing on molecular, biology and genetics tend to receive citations from journals in the fields of molecular biology and immunology (z=4.341, f=29780). Figure 5 The dual-map overlay of journals on GPP. Analysis of Keyword Co-Occurrence and Bursts The entries that were retrieved yielded a total of 1840 keywords. Figure 6A presents the keyword co-occurrence visualization map, with each node’s size representing the frequency of occurrence. According to Table 5 , the most frequently occurring keywords, excluding GPP (n=385), were psoriasis (n=185), interleukin (IL) −36 (n=121), plaque psoriasis (n=80), skin-disease (n=78), and antagonist deficiency (n=70), suggesting these areas were focal points in GPP studies. Table 5 Top 10 Keywords Related to GPP Figure 6 Keywords analysis for research of GPP (2003–2023). (A) Clustering co-occurrence map of keywords. (B) Distribution of keywords based on the average time of appearance. (C) Time-zone view of keyword co-occurrence. The keywords were classified into four categories represented by differently colored circles based on the strength of connections between keywords ( Figure 6A ). The red cluster primarily represents GPP, encompassing terms like skin-disease, IL-1, nuclear transcription factor-kappa B (NF-κB), and inflammation. The yellow cluster is related to psoriasis (including cyclosporine, acitretin, and biologic agents). The blue clusters focus on plaque psoriasis (including secukinumab, ustekinumab, and IL-17). The main keywords in the green cluster are IL-36 (including antagonist deficiency, psoriasis vulgaris, and ap1s3 mutations). The color intensity within the region suggested that the distribution of keywords follows a chronological order ( Figure 6B ). As shown in Figure 6B , the prominent areas of research in GPP over the past five years included safety, secukinumab, spesolimab, ap1s3 mutations, and IL-36. Furthermore, a visual representation of keyword co-occurrence based on time zones was generated ( Figure 6C ), aiding in observing the sequential emergence of research trends and the evolving directions of GPP research over time. Figure 7 highlights the 20 most prominent keywords exhibiting significant citation bursts. Between 2003 and 2023, “efficacy” showed the greatest burst strength (9.5), followed by “safety” (9.2) and “childhood psoriasis” (7.02). Additionally, “moderate”, “ixelizumab treatment”, “mutations”, “efficacy”, and “safety” sustained prominence until 2023, indicating their relevance in current research trends. Figure 7 Top 20 keywords with the strongest citation bursts related to GPP (2003–2023). Analysis of Co-Cited References and Reference Bursts Table 6 lists the 10 most cited references. The paper published by Marrakchi et al 8 in the New England Journal of Medicine (70) was the most referenced, indicating its significance as a foundational work in this particular field. Figure 8 displays the ten references with the most pronounced citation bursts, with the initial burst of co-cited references starting in 2011. The article with the strongest burst (33.72) was published by Marrakchi et al 8 in 2011. Additionally, the paper titled “An update on generalized pustular psoriasis 9 ” experienced a significant burst lasting until 2023. Table 6 Top-10 Most Co-Cited References from 2003 to 2023 Figure 8 Top 15 references with the strongest citation bursts related to field of GPP (2003–2023). The co-citation associations among references were visualized in a network with 280 nodes (references) and 324 linkages ( Figure 9A ). Figure 9B illustrates the 16 most prominent clusters in the reference co-citation network, mapping to the field’s primary study subjects. The five most prominent clusters include “cathepsin g”, “childhood psoriasis”, “pustular psoriasis”, “IL-36rn mutation”, and “disease management”. Figure 9C depicts the development of the sixteen largest clusters through time, shedding light on the changing scientific significance of co-cited references. The most recent clusters are “cathepsin g” (#0), “pustular psoriasis” (#2), “disease management” (#4), “new era” (#6), and “erythrodermic psoriasis” (#11). Figure 9 Analysis of co-cited references in the field of GPP (2003–2023). (A) The network of co-cited references. (B) Clustering visualization map of the co-cited references. (C) Timeline visualization map of the co-cited references. Discussion Researchers can gain a deeper understanding of the current state of research on a specific topic and anticipate future trends with the help of bibliometrics. This study is the first attempt to investigate GPP through the utilization of bibliometric analysis and visualization techniques. General Information A total of 578 papers were published in 174 journals between 2003 and 2023. These papers were authored by 2758 individuals affiliated with 273 institutions spanning 57 countries. The data presented in Figure 2 illustrates a general upward trend in the overall quantity of publications over the previous twenty years. GPP research has notably emerged as a prominent area of study in recent years, showcasing an excellent development trend. An examination of contributions by country highlights the United States as the leader, constituting 19.1% of overall publications. Germany, with the utmost centrality of 0.53, serves as a bridge in global collaboration. Approximately 2000 institutions globally contributed to GPP research, with UDICE-French Research Universities demonstrating the highest productivity. Among the top ten research institutes, four were from France, with the Institut National de la Sante et de la Recherche Medicale having the highest impact. As depicted in Figure 3B , inter-institutional collaboration primarily occurs within national boundaries, lacking international interactions. This limitation has the potential to impede the progress and advancement of the discipline. Therefore, it is strongly recommended to coordinate research resources across relevant national departments to promote cooperation among research institutions. Akiyama M was identified as the most prolific author in terms of published articles and possesses the highest H-index in this field. His research focuses on rare intractable hereditary skin diseases and inflammatory skin diseases. 11–13 Interestingly, Bachelez H, despite a modest publication record of only 10 articles, was associated with the highest number of citations. The author cooperation network revealed the formation of many academic teams and robust collaboration among diverse research groups. Of the top 10 journals, six were situated within the first quartile of the Journal Citation Reports, with two possessing an IF exceeding 10, indicating a high standard of articles within this discipline. An in-depth analysis of co-citation frequency indicates that Marrakchi S, Fujita H, and other representatives have a higher frequency of citation overall. The article authored by Marrakchi et al 8 emerged as the most commonly co-cited publication. He found that an abnormality in the structure and function of IL-36Ra causes the unregulated release of inflammatory cytokines in GPP. The second most co-cited paper was a guideline for Japanese patients with GPP published by Fujita et al. 10 Emerging Topics Pathogenesis Fifty percent of patients with GPP also have concomitant psoriasis vulgaris (also known as plaque psoriasis). 14 , 15 GPP has traditionally been viewed as a subset of psoriasis vulgaris, but more recent literature recognizes GPP as having a unique etiology, phenotypically, and pathophysiology. 16 , 17 Mechanisms linked to dysregulation of the innate immune system in GPP include the disruption of the IL-36 inflammatory pathway, the stimulation of inflammatory keratinocyte responses, and the recruitment of neutrophils. 18 The pathogenesis of psoriasis vulgaris is mostly influenced by the adaptive immune system, wherein the cytokine IL-17 plays a substantial role. 19 , 20 In contrast to plaque psoriasis lesions, GPP lesions show elevated levels of neutrophilic chemokines and neutrophil and monocyte transcripts. 21 In Japan, 82% of solely diagnosed GPP patients exhibit IL-36 receptor antagonist (IL36RN) mutations. In contrast, a considerably lower percentage (10%) of Japanese patients diagnosed with both GPP and psoriasis vulgaris presented with the same mutation. 22 Genetic testing, particularly for IL36RN mutations is recommended for GPP diagnosis. The relevance of genetic predisposition in the etiology of GPP has been demonstrated in several familial case studies. Defects in genes such as IL36RN, 23 caspase recruitment domain family member 14 protein (CARD14), 24 adaptor related protein complex 1 subunit sigma 3 (AP1S3), 25 myeloperoxidase(MPO), 26 and serpin peptidase inhibitor clade A member 3(SERPINA3) 27 —have been identified in a subset of GPP patients. The first pathogenic variant associated with GPP was the homozygous IL36RN mutation. 28 This mutation has been reported to inhibit the function of IL-36Ra, leading to increased activation of signal pathways linked with IL-36 and exacerbating GPP inflammations. 8 Mutations in the CARD14 gene have also been linked to GPP development. 18 CARD14 stimulates NF-κB signaling, upregulating chemokine ligand 20 (CCL20) and IL-8 gene expression in keratinocytes, triggering the recruitment of inflammatory cells and causing epidermal inflammation. 29 AP1S3 mutations have been associated with GPP, leading to the destabilization of the adaptor protein complex 125. Keratinocytes with AP1S3 mutations exhibit reduced autophagosome production, resulting in p62 accumulation. 30 Elevated p62 levels heighten NF-κB signalling, leading to the upregulation of IL-36α and overstimulation of the IL-36 pathway. 31 In addition, it is worth noting that AP1S3 mutations in the context of GPP, palmoplantar pustulosis, and acetylcholine may exhibit varying penetrance influenced by sex-specific variables. This is supported by the observation that nearly all individuals carrying AP1S3 disease alleles were female, though statistical significance was not achieved (p = 0.06). 32 It has been established that the gene SERPINA3 is responsible for encoding alpha-1 anti-chymotrypsin, which is an inhibitor of cathepsin G. Cathepsin G is a protease released by neutrophils and plays a role in the activation of IL-36 precursors. 27 Treatment A globally recognized therapeutic guidance for GPP is still lacking, and treatment approaches often reflects the recommendations for plaque psoriasis. 33 Current GPP treatment alternatives can be divided into two main groups: biological and non-biological systemic agents. Immunosuppressive medications, such as corticosteroids, acitretin, cyclosporine, and methotrexate, are commonly used as first-line therapies to suppress acute inflammation GPP. 34 However, there is limited, weak evidence for their clinical efficacy in GPP patients. Biological agents have received approval for the treatment of GPP, and several clinical research studies have substantiated the efficacy and safety of biologics in treating GPP. At present, only one GPP-specific treatment. Spesolimab, a monoclonal antibody targeting the human IL-36 receptor, has recently been approved for GPP disease. 35 Spesolimab is not only the only on-label biologic for GPP management but is also the first biologic medicine licensed for this usage. 36 Research by Potestio et al 37 indicated the effectiveness and generally positive safety profile of spesolimab in patients with a GPP flare. Further research is warranted for a comprehensive understanding of spesolimab’s effectiveness, safety, and long-term results in GPP patients. Antagonistic antibodies targeting the IL-36 receptor have the potential to impede the signaling system responsible for triggering active GPP flares. Anakinra, a recombinant IL-1 receptor antagonist, has shown efficacy in GPP treatment in case reports. 38 Secukinumab, ixekizumab, and brodalumab, all three of these biological drugs are inhibitors of IL-17A and IL-17RA, have been approved for use in patients with GPP in Japan. 39–41 Bimekizumab, a monoclonal antibody that specifically binds to and inhibits the activity of IL-17 A and F, has been demonstrated efficacy and safety in plaque psoriasis management. 42 Hagino et al 43 documented the effective resolution of two GPP cases following bimekizumab treatment. The synthesis of IL-17 is reportedly regulated by IL-23, which subsequently induces the production of IL-36R agonists, leading to excessive activation of the IL-36 pathway. 17 Guselkumab, a monoclonal antibody targeting human IL-23, was demonstrated to be effective and safe in patients with GPP and erythrodermic psoriasis. 44 Risankizumab, a new IL-23p19 inhibitor, has shown promise in the treatment of GPP. 45 , 46 Ustekinumab, a monoclonal antibody inhibiting IL-12 and IL-23, has demonstrated efficacy in a patient diagnosed with GPP. 47 Tumor necrosis factor inhibitors, including adalimumab, 48 infliximab, 49 and certolizumab pegol, were primarily authorized for GPP management in Japan based on empirical evidence from individual case reports. Limitations This study exhibits inherent deficiencies and constraints typical in bibliometrics. Initially, this investigation exclusively accessed the widely utilized WOSCC database, which may have led to the inclusion of incomplete and biased research. Indeed, our findings could vary if alternative databases were employed. Additionally, our study exclusively focused on articles and reviews published in English language, potentially limiting the comprehensiveness of our findings. Addressing these restrictions is imperative in future endeavors. Conclusion The quantity of scholarly articles in this particular discipline has exhibited a general upward trend over the years, indicating a noteworthy emphasis by researchers on the subject of GPP. Globally, the United States holds a prominent position as the leading country in GPP research. UDICE-French Research Universities stands out as the research institution exerting the most influence on academic accomplishments. Akiyama M has made significant contributions to the field of GPP. The Journal of Dermatology is widely recognized as the most influential journal in this domain. Despite the widespread engagement among institutes and authors globally in this area, there remains a necessity to enhance academic interchange and cooperation. Recent research focuses have explored topics such as “safety”, “secukinumab”, “spesolimab”, “ap1s3 mutations”, and “IL-36”. These research areas hold significant importance and serve as a foundational knowledge base for further investigations. The forefront of research in this field includes “moderate”, “ixekizumab treatment”, “mutations”, “efficacy”, and “safety”. As our understanding of the underlying mechanisms and genetic factors contributing to GPP has improved, the opportunity for specific biological therapy to enhance patient outcomes has increased. In conclusion, our study provides an objective and comprehensive analysis of research on GPP, offering significant insights for future investigations in related areas. Abbreviations GPP, Generalised pustular psoriasis; WoSCC, Web of Science Core Collection; CARD14, caspase recruitment domain family member 14 protein; AP1S3, adaptor related protein complex 1 subunit sigma 3; MPO, myeloperoxidase; SERPINA3, serpin peptidase inhibitor clade A member 3; CCL20, chemokine ligand 20; NF-κB, nuclear transcription factor-kappa B. Data Sharing Statement Further information and requests for data may be directed to and will be fulfilled by the Lead Contact: Prof. Aimin Liu ( [email protected] ). Consent for Publication The details of the manuscript can be published and all the authors providing consent have been shown the article contents to be published. Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Funding The present study was supported by a grant from the National Natural Science Foundation of China (NO. 81874471), the Key Research Projects of Higher Education Institutions in Henan Province (NO. 24A360010) and Special Project for the Scientific Research of Traditional Chinese Medicine in Henan Province (NO. 2022ZY1085). The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Disclosure

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